Ultrasonically guided percutaneous ethanol injection therapy for large sized hepatocellular carcinoma.

Seki, Toshihito; Kubota, Yoshihiro; Kunieda, K; Kanou, Yoshihiko; Sato, Masahiro; Shiro, Tomohiro; Mizuno, Takako; Shiozaki, Yasuko; Inoue, K

doi:10.2957/kanzo.32.613

Cited by 24 publications

(27 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the latter case, transarterial embolization, radiation therapy, chemotherapy, and local puncture therapy are the main options available. While percutaneous ethanol injection therapy [16] is a type of local puncture therapy that has been performed since the 1980s, local ablative therapy such as microwave coagulation therapy [17] and RFA therapy were subsequently developed. Currently, RFA is the main form of local puncture therapy administered due to its ability to provide local control of HCC.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Honda

Seike

Oribe

et al. 2016

WJH

View full text Add to dashboard Cite

AIM:To identify factors that influence long-term liver function following radiofrequency ablation (RFA) in patients with viral hepatitis-related hepatocellular carcinoma. METHODS:A total of 123 patients with hepatitis B virus-or hepatitis C virus-related hepatocellular carcinoma (HCC) (n = 12 and n = 111, respectively) were enrolled. Cumulative rates of worsening Child-Pugh (CP) scores (defined as a 2-point increase) were examined. RESULTS:CP score worsening was confirmed in 22 patients over a mean follow-up period of 43.8 ± 26.3 mo. Multivariate analysis identified CP class, platelet count, and aspartate aminotransferase levels as significant predictors of a worsening CP score (P = 0.000, P = 0.011 and P = 0.024, respectively). In contrast, repeated RFA was not identified as a risk factor for liver function deterioration. CONCLUSION:Long-term liver function following RFA was dependent on liver functional reserve, the degree Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy Retrospective Cohort Study ORIGINAL ARTICLEof fibrosis present, and the activity of the hepatitis condition for this cohort. Therefore, in order to maintain liver function for an extended period following RFA, suppression of viral hepatitis activity is important even after the treatment of HCC. Core tip: This study was conducted to identify risk factors for liver function deterioration following radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC) and viral hepatitis. A total of 123 patients with hepatitis B virus-or hepatitis C virusrelated HCC were enrolled. Cumulative rates of worsening Child-Pugh (CP) scores (defined as a 2-point increase) following RFA were examined. CP class, platelet count, and aspartate aminotransferase levels were identified as significant predictors of a worsening CP score. Suppression of viral hepatitis activity with anti-viral therapy is important even after the treatment of HCC in order to maintain liver function following RFA.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Honda

Seike

Oribe

et al. 2016

WJH

View full text Add to dashboard Cite

show abstract

“…Percutaneous ethanol injection has also been used extensively to treat hepatocellular carcinomas, especially tumors not exceeding 2-3 cm in diameter [28]. Histopathologic examination after therapy revealed that in many cases ethanol injection can completely destroy the tumor [29,30].…”

Section: Current Therapeutic Approachmentioning

confidence: 99%

Octreotide for Cancer of the Liver and Biliary Tree

Kouroumalis¹

2001

Chemotherapy

View full text Add to dashboard Cite

Inoperable liver tumors have an unfavorable natural course despite various therapeutic modalities. Octreotide, a somatostatin analog, has shown considerable antitumor activity on animal models of various hepatic tumors and on isolated cell culture lines. In this paper, a review of the experimental evidence is presented. Moreover clinical papers of case reports of uncontrolled studies of patients are also reviewed. The majority of clinical studies provide evidence of a clinical and biochemical response of liver endocrine tumors while regression of tumor size is a rare event. A randomized controlled trial of octreotide in the treatment of advanced hepatocellular carcinoma has shown a significant survival benefit in the treated patients. Literature reports indicate a stimulatory effect of octreotide on Kupffer cells as a possible antitumor mechanism, but other antiproliferative actions of octreotide have been suggested but not proved. Finally the question of the presence and affinity of somatostatin receptors on liver tumor tissue is discussed. In conclusion, according to our experience, octreotide administration is the best available treatment for advanced inoperable hepatocellular carcinoma and future better patient selection, based on receptor subtypes, might further improve the results.

show abstract

“…Serum AFP levels decreased in all but one patient; in the sole exception, one of four nodules (5 em in diameter) increased in size after completion of treatment (relapsing HCC). A new PEl session was accomplished, obtaining 100% necrosis as assessed by CT.…”

Section: Resultsmentioning

confidence: 87%

Percutaneous ethanol injection under sonographic guidance of hepatocellular carcinoma in compensated and decompensated cirrhotic patients

Giorgio

Tarantino

Francica

et al. 1992

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

Forty·six patients with cirrhosis and 75 biopsy-proved hepatocellular carcinoma (HCC) nodules underwent percutaneous ethanol injection (PEl) regardless of number (up to five) and size (mean diameter, 3.6 em) of tumoral lesions and clinical severity of cirrhosis (11 patients in Child's class C were included).Ethanol was injected under sonographic guidance through 20 to 22 gauge needles so as to obtain homogeneous hyperechogenicity of lesions. A total of 271 PEl sessions were carried out, delivering 2 to 14 ml per session .All nodules but one decreased in size, and seven were no longer appreciable on sonography. Recurrence was detected in two patients.

show abstract

Ultrasonically guided percutaneous ethanol injection therapy for large sized hepatocellular carcinoma.

Cited by 24 publications

References 0 publications

Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Octreotide for Cancer of the Liver and Biliary Tree

Percutaneous ethanol injection under sonographic guidance of hepatocellular carcinoma in compensated and decompensated cirrhotic patients

Contact Info

Product

Resources

About