Ultrasonically Assisted Polysaccharide Microcontainers for Delivery of Lipophilic Antitumor Drugs: Preparation and in Vitro Evaluation

Akasov, Roman; Bоrodinа, Tatyana N.; Zaytseva, Ekaterina M.; Sumina, Anastasia; Букреева, Т. В.; Буров, С. В.; Марквичева, Елена

doi:10.1021/acsami.5b04141

Cited by 24 publications

(17 citation statements)

References 53 publications

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“…The low penetration could have been partly due to the positive surface charge of the nanoparticles or other properties as other particles with similar sizes were observed to be taken up by the spheroids. Better penetration in a similar size range was achieved with chitosan and xanthan coated soybean oil spheres . Particles, with encapsulated thymoquinone and polysaccharide coating, with sizes of 500 nm and 2 µm, respectively, were prepared by ultrasonication.…”

Section: Using Mcts To Evaluate Nano Drug Carriersmentioning

confidence: 98%

“…Similar to proteins, polysaccharides are attractive carriers that have widely been employed to deliver drugs into MCTS. Soybean oil droplets were coated with chitosan and xanthan gum to create a biocompatible surface while an alginate and chitosan shell could enhance the properties of ceramic, calcium phosphate, or PLGA nanoparticles . Coating of micelles with chitosan or hyaluronic acid, or by simply using hyaluronic acid nanogel, can furthermore enhance the movement into MCTS that overexpress the CD44 receptor .…”

Section: Using Mcts To Evaluate Nano Drug Carriersmentioning

confidence: 99%

“…Particles, with encapsulated thymoquinone and polysaccharide coating, with sizes of 500 nm and 2 µm, respectively, were prepared by ultrasonication. Although both particles were taken up by mouse melanoma M‐3 cells and displayed penetration into M‐3 tumor spheroids, the smaller particles were clearly more efficient …”

Section: Using Mcts To Evaluate Nano Drug Carriersmentioning

confidence: 99%

“…Better penetration in a similar size range was achieved with chitosan and xanthan coated soybean oil spheres. [87] Particles, with encapsulated thymoquinone and polysaccharide coating, with sizes of 500 nm and 2 µm, respectively, were prepared by Small 2018, 14,1702858 Reproduced with permission. [153] Copyright 1981, Springer.…”

Section: Influence Of Nanoparticle Sizementioning

confidence: 99%

“…Although both particles were taken up by mouse melanoma M-3 cells and displayed penetration into M-3 tumor spheroids, the smaller particles were clearly more efficient. [87] Significantly enhanced penetration was typically observed with nanoparticles in the low nanometer range. A study using polystyrene particles revealed the faster penetration of smaller nanoparticles (20 and 40 nm) into MCF-7 spheroids while the 100 nm nanoparticles lagged behind.…”

Section: Influence Of Nanoparticle Sizementioning

confidence: 99%

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Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles

Stenzel

2018

Small

170

140

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Multicellular tumor spheroid models (MCTS) are often coined as 3D in vitro models that can mimic the microenvironment of tissues. MCTS have gained increasing interest in the nano-biotechnology field as they can provide easily accessible information on the performance of nanoparticles without using animal models. Considering that many countries have put restrictions on animals testing, which will only tighten in the future as seen by the recent developments in the Netherlands, 3D models will become an even more valuable tool. Here, an overview on MCTS is provided, focusing on their use in cancer research as most nanoparticles are tested in MCTS for treatment of primary tumors. Thereafter, various types of nanoparticles-from self-assembled block copolymers to inorganic nanoparticles, are discussed. A range of physicochemical parameters including the size, shape, surface chemistry, ligands attachment, stability, and stiffness are found to influence nanoparticles in MCTS. Some of these studies are complemented by animal studies confirming that lessons from MCTS can in part predict the behaviour in vivo. In summary, MCTS are suitable models to gain additional information on nanoparticles. While not being able to replace in vivo studies, they can bridge the gap between traditional 2D in vitro studies and in vivo models.

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Section: Using Mcts To Evaluate Nano Drug Carriersmentioning

confidence: 98%

Section: Using Mcts To Evaluate Nano Drug Carriersmentioning

confidence: 99%

Section: Using Mcts To Evaluate Nano Drug Carriersmentioning

confidence: 99%

Section: Influence Of Nanoparticle Sizementioning

confidence: 99%

Section: Influence Of Nanoparticle Sizementioning

confidence: 99%

See 3 more Smart Citations

Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles

Stenzel

2018

Small

170

140

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Sonochemistry‐Assembled Stimuli‐Responsive Polymer Microcapsules for Drug Delivery

Wang

et al. 2018

Adv Healthcare Materials

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Stimuli-responsive polymer microcapsules (PMs) fabricated by the sonochemical method have emerged for developing useful drug delivery systems, and the latest developments are mainly focusing on the synthetic strategies and properties such as structure, size, stability, loading capacity, drug delivery, and release. There, the primary attribution of sonochemistry is to offer a simple and practical approach for the preparation of PMs. Structure, size, stability, and properties of PMs are designed mainly according to synthetic materials, implementation schemes, or specific demands. Numerous functionalities of PMs based on different stimuli are demonstrated: targeting motion in a magnetic field or adhering to the living cells with sensitive sites through molecular recognition, and stimuli-triggered release including enzymatic catalysis, chemical reaction as well as physical or mechanical process. The current review discusses the basic principles and mechanisms of stimuli effects, and describes the progress in the application such as targeted drug systems and controlled drug systems, and also gives an outlook on the future challenges and opportunities for drug delivery and theranostics.

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Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

et al. 2021

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Wireless nano‐/micromotors powered by chemical reactions and/or external fields generate motive forces, perform tasks, and significantly extend short‐range dynamic responses of passive biomedical microcarriers. However, before micromotors can be translated into clinical use, several major problems, including the biocompatibility of materials, the toxicity of chemical fuels, and deep tissue imaging methods, must be solved. Nanomaterials with enzyme‐like characteristics (e.g., catalase, oxidase, peroxidase, superoxide dismutase), that is, nanozymes, can significantly expand the scope of micromotors’ chemical fuels. A convergence of nanozymes, micromotors, and microfluidics can lead to a paradigm shift in the fabrication of multifunctional micromotors in reasonable quantities, encapsulation of desired subsystems, and engineering of FDA‐approved core–shell structures with tuneable biological, physical, chemical, and mechanical properties. Microfluidic methods are used to prepare stable bubbles/microbubbles and capsules integrating ultrasound, optoacoustic, fluorescent, and magnetic resonance imaging modalities. The aim here is to discuss an interdisciplinary approach of three independent emerging topics: micromotors, nanozymes, and microfluidics to creatively: 1) embrace new ideas, 2) think across boundaries, and 3) solve problems whose solutions are beyond the scope of a single discipline toward the development of micro‐bio‐chemo‐mechanical‐systems for diverse bioapplications.

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Ultrasonically Assisted Polysaccharide Microcontainers for Delivery of Lipophilic Antitumor Drugs: Preparation and in Vitro Evaluation

Cited by 24 publications

References 53 publications

Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles

Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles

Sonochemistry‐Assembled Stimuli‐Responsive Polymer Microcapsules for Drug Delivery

Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

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