Ultrasonic synthetic technique to manufacture a pHEMA nanopolymeric-based vaccine against the H6N2 avian influenza virus: a preliminary investigation

Poinern, Gérrard Eddy Jai; Le, Xuan Thi Thanh; Shan, Shiguang; Ellis, T.M.; Fenwick, Stan; Edwards, John; Fawcett, Derek

doi:10.2147/ijn.s24272

Cited by 11 publications

(7 citation statements)

References 43 publications

(56 reference statements)

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“…These new nanomaterials are increasingly becoming the subject of many investigations in several fields, particularly those of engineering, biotechnology, and biomedical sciences. The use of nanomaterials of biodegradable polymers is being extensively studied as they provide an attractive alternative for a number of environmental applications by providing a method for extraction of trace metal and removal of toxic metal ions from water and wastewater …”

Section: Introductionmentioning

confidence: 99%

Adsorption isotherms, kinetic, and desorption studies on removal of toxic metal ions from aqueous solutions by polymeric adsorbent

Samadi

Hasanzadeh

Rasad

2014

J of Applied Polymer Sci

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Adsorption of Cd(II), Co(II), and Ni(II) on aminopyridine modified poly(styrene-alt-maleic anhydride) crosslinked by 1,2-diaminoethane as an ion exchange resin has been investigated in aqueous solution. Adsorption behavior of these metal ions on the resin was studied by varying the parameters such as pH (2-6), adsorbent dose (0-4.0 g/L), contact time (0-240 min), and metal ions concentration (20-300 mg/L). Adsorption percentage was increased by increasing each of these parameters. The isotherm models such as: Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich were used to describe adsorption equilibrium. The results showed that the best fit was achieved with the Langmuir isotherm equation, yielding maximum adsorption capacities of 81.30, 49.02, and 76.92 mg/g for Cd(II), Co(II), and Ni(II), respectively. The pseudo-first-order, pseudo-second-order, and intra-particle diffusion kinetics equations were used for modeling of adsorption data and it was shown that pseudo-second-order kinetic equation could best describe the adsorption kinetics. The intra-particle diffusion study revealed that external diffusion might be involved in this case.

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Section: Introductionmentioning

confidence: 99%

Adsorption isotherms, kinetic, and desorption studies on removal of toxic metal ions from aqueous solutions by polymeric adsorbent

Samadi

Hasanzadeh

Rasad

2014

J of Applied Polymer Sci

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“…Poly(2-hydroxyethyl methacrylate) (pHEMA) has been utilized extensively in biological and biomedical applications [1][2][3][4][5][6][7][8][9][10][11] because it is nontoxic and possesses adequate mechanical strength. [12][13][14] Applications of pHEMA films include biosensors, [15][16][17][18] contact lenses, 19,20 controlled drug release, [21][22][23][24] and resistance to protein adhesion. [25][26][27] Common methods for fabricating thin pHEMA films include graft copolymerization 12,28,29 and spin casting from polymer solutions.…”

Section: Introductionmentioning

confidence: 99%

Photoinitiated chemical vapor deposition of cytocompatible poly(2‐hydroxyethyl methacrylate) films

McMahon

Pfluger

Sun

et al. 2013

J Biomedical Materials Res

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Poly(2-hydroxyethyl methacrylate) (pHEMA) is a widely utilized biomaterial due to lack of toxicity and suitable mechanical properties; conformal thin pHEMA films produced via chemical vapor deposition (CVD) would thus have broad biomedical applications. Thin films of pHEMA were deposited using photoinitiated CVD (piCVD). Incorporation of ethylene glycol diacrylate (EGDA) into the pHEMA polymer film as a crosslinker, confirmed via Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, resulted in varied swelling and degradation behavior. 2-Hydroxyethyl methacrylate-only films showed significant thickness loss (up to 40%), possibly due to extraction of low-molecular-weight species or erosion, after 24 h in aqueous solution, whereas films crosslinked with EGDA (9.25-12.4%) were stable for up to 21 days. These results differ significantly from those obtained with plasma-polymerized pHEMA, which degraded steadily over a 21-day period, even with crosslinking. This suggests that the piCVD films differ structurally from those fabricated via plasma polymerization (plasma-enhanced CVD). piCVD pHEMA coatings proved to be good cell culture materials, with Caco-2 cell attachment and viability comparable to results obtained on tissue-culture polystyrene. Thus, thin film CVD pHEMA offers the advantage of enabling conformal coating of a cell culture substrate with tunable properties depending on method of preparation and incorporation of crosslinking agents.

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“…This prospect might arise in AIVs as well. Although the use of nanotechnology to deliver AI vaccines may improve vaccine efficacy and overcome the recombination challenges [190,191], for now, we advocate strict biosecurity procedures coupled with the implementation of worldwide interagency surveillance efforts modeled on those of the USA and Europe in high-risk regions, such…”

Section: Future Perspectivementioning

confidence: 99%

Avian Influenza: Virology, Diagnosis and Surveillance

2013

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Avian influenza virus (AIV) is the causative agent of a zoonotic disease that affects populations worldwide with often devastating economic and health consequences. Most AIV subtypes cause little or no disease in waterfowl, but outbreaks in poultry can be associated with high mortality. Although transmission of AIV to humans occurs rarely and is strain dependent, the virus has the ability to mutate or reassort into a form that triggers a life-threatening infection. The constant emergence of new influenza strains makes it particularly challenging to predict the behavior, spread, virulence or potential for human-to-human transmission. Because it is difficult to anticipate which viral strain or what location will initiate the next pandemic, it is difficult to prepare for that event. However, rigorous implementation of biosecurity, vaccination and education programs can minimize the threat of AIV. Global surveillance programs help record and identify newly evolving and potentially pandemic strains harbored by the reservoir host.

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Ultrasonic synthetic technique to manufacture a pHEMA nanopolymeric-based vaccine against the H6N2 avian influenza virus: a preliminary investigation

Cited by 11 publications

References 43 publications

Adsorption isotherms, kinetic, and desorption studies on removal of toxic metal ions from aqueous solutions by polymeric adsorbent

Adsorption isotherms, kinetic, and desorption studies on removal of toxic metal ions from aqueous solutions by polymeric adsorbent

Photoinitiated chemical vapor deposition of cytocompatible poly(2‐hydroxyethyl methacrylate) films

Avian Influenza: Virology, Diagnosis and Surveillance

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