Ultrasonic spray deposition of PEGDE-crosslinked chitosan/graphene oxide coatings for enhancing gas barrier properties of polybutylene succinate films

Cabrini, Alessia; Esfahani, Arash Ghalayani; Petraconi, André; Lavorgna, Marino; Nardo, Luigi De; Buonocore, Giovanna G.; Andrade, Ricardo; Cerruti, Pierfrancesco

doi:10.1016/j.porgcoat.2023.107760

Cited by 2 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chitosan is a biopolymer that has garnered considerable attention in the field of biomedical applications. This is due to its various beneficial properties, including antibacterial, antifungal, and antitumor activities, as well as its capacity to promote tissue regeneration and wound healing [30]. These properties make it a promising material for various biomedical applications, such as drug delivery, tissue engineering, wound dressings, and implant coatings [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Bactericidal Activity of Silver-Doped Chitosan Coatings via Electrophoretic Deposition on Ti6Al4V Additively Manufactured Substrates

Ghalayani Esfahani,

Sartori,

Bregoli

et al. 2023

Polymers

Self Cite

View full text Add to dashboard Cite

Prosthetic reconstruction can serve as a feasible alternative, delivering both functional and aesthetic benefits to individuals with hand and finger injuries, frequent causes of emergency room visits. Implant-related infections pose significant challenges in arthroplasty and osteosynthesis procedures, contributing to surgical failures. As a potential solution to this challenge, this study developed a new class of silver (Ag)-doped chitosan (CS) coatings via electrophoretic deposition (EPD) on osseointegrated prostheses for infection therapy. These coatings were successfully applied to additively manufactured Ti6Al4V ELI samples. In the initial phase, the feasibility of the composite coating was assessed using the Thermogravimetric Analysis (TGA) and Attenuated Total Reflection (ATR) techniques. The optimized structures exhibited impressive water uptake in the range of 300–360%. Codeposition with an antibacterial agent proved effective, and scanning electron microscopy (SEM) was used to examine the coating morphology. Biologically, CS coatings demonstrated cytocompatibility when in direct contact with a fibroblast cell line (L929) after 72 h. When exposed to the Staphylococcus epidermidis strain (ATCC 12228), these coatings inhibited bacterial growth and biofilm formation within 24 h. These findings underscore the significant potential of this approach for various applications, including endoprostheses like hip implants, internal medical devices, and transcutaneous prostheses such as osseointegrated limb prosthetics for upper and lower extremities.

show abstract