Ultrasonic or Microwave Modified Continuous Flow Chemistry for the Synthesis of Tetrahydrocannabinol: Observing Effects of Various Solvents and Acids

Abstract

Synthesizing tetrahydrocannabinol is a lengthy process with minimal yields and little applicability on an industrial scale. To close the gap between bench chemistry and industry process chemistry, this paper introduces a small-scale flow chemistry method that utilizes a microwave or ultrasonic medium to produce major tetrahydrocannabinol isomers. This process produces excellent yields and minimal side products, which leads to more efficient large-scale production of the desired cannabinoids.

HPLC Method for Better Separation of THC Isomers to Ensure Safety and Compliance in the Hemp Market

“…Tetrahydrocannabinol (THC), the primary psychoactive component of Cannabis sativa, is accompanied in most consumer-ready products by a slew of minor cannabinoids, most notably CBD, which is nonpsychoactive. In recent years, the synthetic production of THC variants, − such as Δ 8 -THC and Δ 9 -THC, has become a focal point within the hemp industry, presenting both opportunities and challenges. While the potential therapeutic benefits of cannabinoids are widely acknowledged, a recent surge in popularity and availability of these products raises concerns about their quality, safety, and legality.…”