Ultrasonic Methods of the Cells Separation in Human Blood

Włoch, Andrzej; Czyż, H.; Jasiński, Tadeusz

doi:10.12693/aphyspola.128.234

Cited by 6 publications

(7 citation statements)

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“…This paper presents the theoretical analysis of the mechanisms of the action of drift forces on cells in fluid in a standing ultrasonic wave. The results of our research are the next step to a controlled ultrasonic separation of red cells in human blood [7][8][9]. Summing up the considerations it can be stated that: a) The radiation drift force directs cells to nodes or loops of the ultrasonic wave.…”

Section: Discussionmentioning

confidence: 81%

“…Now, we estimate the constants α and β and thus evaluate the two terms presenting friction in Eq. (8). Assuming that the same numerical values which were used in calculating the quantity A D it can estimate the constants α and β.…”

Section: The Equation Of the Motion Of Red Cells Affected By The Drifmentioning

confidence: 99%

“…(8) can be omitted. The equation of motion (8) after the rejection of the Oseen correction has the form…”

Section: The Equation Of the Motion Of Red Cells Affected By The Drifmentioning

confidence: 99%

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Aspects of Applicability King - St. Clair Approximation in a Non-Newtonian Fluid Mechanics

2017

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This studyis a contribution to research on the biomedical and clinical applications of ultrasound. Our research concerns the procedure for the separation of human blood fractions-erythrocytes. Ultrasonic waves can be used for the separation of cells in human blood. From a physical point of view, the human blood is a suspension of liquids and solids (cell elements), and behaves like a non-Newtonian fluid. Our work is devoted to the problem of the motion of red cells in human blood under the influence of ultrasonic wave. It defines a range of the applicability of approximation consisting in neglecting the nonlinear term in the friction force. It also analyzes the general properties of the equation of motion of the cell in the case of large attenuation constants, corresponding to the values of the drift forces for the cells with radii of a few µm. Finally, it defines the applicability criterion of the so-called King-St Clair approximation consisting in the assumption of equilibrium between the drift and the Stokes viscosity forces, neglecting the term representing inertia. This approximation permits analytical estimation of the time constants for the cell transport to points of stable equilibrium in an ultrasonic standing wave field.

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Section: Discussionmentioning

confidence: 81%

Section: The Equation Of the Motion Of Red Cells Affected By The Drifmentioning

confidence: 99%

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Aspects of Applicability King - St. Clair Approximation in a Non-Newtonian Fluid Mechanics

2017

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“…In theoretical papers on the application of ultrasonic waves in medicine, approximate solutions are sometimes adopted instead of precise ones in order to present physical processes and show applicatory aspects of the topic. Assuming a general dependence of resistance forces on velocity and dependence of drift forces on the position, the following motion equation is obtained (Włoch et al, 2015):…”

Section: Comparison Of Effectiveness Of Different Factors Responsible...mentioning

confidence: 99%

Archives of Acoustics

Włoch

Czyż

Jasiński

2019

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This paper presents an analysis of use of ultrasonic standing wave in cell separation from bodily fluids based on the example of erythrocyte separation from plasma. It describes movement of red blood cells in plasma under the influence of the acoustic field (whose forces result from interaction of red blood cells with plasma as the vibrating medium) and under the influence of resistance forces in Stokes' and Oseen's approximation. The general properties of solutions of the motion equation are given. The solutions for the parameters of the ultrasonic wave and blood cells which are interesting in terms of practical applications in medical diagnostics are discussed. Time constants of the cell transportation to the regions of stable equilibrium in the field of ultrasonic standing wave are estimated. The formulas which determine the time needed to obtain the assumed concentration increase in plasma in nodes and/or anti-nodes of the standing wave are derived.

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“…particles per volume unit in a surface described by coordinate x at a time t, continuity equation is expressed as follows[14]: of progressive movement of erythrocyte; kwave number; N0 -initial concentration of erythrocytes; δ -1 -time constant of concentration of erythrocytes.…”

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confidence: 99%

Physics in Medicine and Economy of Contemporary Society

Czyż

Jasiński

2017

pfe

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This paper describes the main methods of separating blood into components. The most common methods used in medicinal practice include centrifugation and filtration. Currently, there has been a lot of research on the application of ultrasound as the new, innovative method of separation of blood components. Ultrasound use is a theoretically elaborated method and experimental research is in process with the aim of its implementation in medical diagnostics. Contemporary societies are aware of the importance of findings of physics as well as of the fact that our everyday life is strongly connected to physics and to technical devices that have been created on the basis of its fundamental laws.

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Ultrasonic Methods of the Cells Separation in Human Blood

Cited by 6 publications

References 2 publications

Aspects of Applicability King - St. Clair Approximation in a Non-Newtonian Fluid Mechanics

Aspects of Applicability King - St. Clair Approximation in a Non-Newtonian Fluid Mechanics

Archives of Acoustics

Physics in Medicine and Economy of Contemporary Society

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