“…On the other hand, multicomponent reactions (MCRs), defined as any process in which three or more reactants combine in one pot to generate a product containing all or most atoms of the starting materials, are highly atom efficient (5)(6)(7)(8). Thus, an ideal MCR involves the simultaneous addition of reactants, catalyst, or reagents at the beginning of the reaction and requires that all reactants couple in an exclusive ordered mode under the same reaction conditions (5)(6)(7)(8). Their superior atom economy, resulting in substantial minimization of waste, labour, time, and cost as well as high efficiency, mild conditions, high convergence, and their general compatibility with green solvents, would justify a central place in the toolbox of green synthetic methodologies (5)(6)(7)(8).…”