Ultrasonic extraction, antioxidant and anticancer activities of novel polysaccharides from Chuanxiong rhizome

Hu, Jie; Jia, Xuejing; Fang, Xiaobin; Li, Peng; He, Chengwei; Chen, Meiwan

doi:10.1016/j.ijbiomac.2015.12.046

Cited by 74 publications

(36 citation statements)

References 26 publications

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“…Increasingly, studies have reported that ultrasonic temperature plays an important role in the extraction yield of polysaccharides (Hu et al, 2016). In the present study, the effect of different temperatures (40,50,60,70, and 80 °C) on the extraction yield of TMP was tested.…”

Section: Ultrasonic Temperaturementioning

confidence: 93%

“…The broad and strong bands at 3395-3386 cm −1 were assigned to the O-H stretching vibration. The small peaks at 2931-2922 cm −1 were due to the stretching and bending vibrations of C-H (Hu et al, 2016). Bands at both 1650-1635 cm −1 and 1417-1406 cm −1 were observed, corresponding to symmetric and asymmetric stretching, respectively, of C=O (Afshari et al, 2015).…”

Section: Ft-ir Analysismentioning

confidence: 94%

“…Different ultrasonic powers have been shown to affect the yield of polysaccharides (Hu et al, 2016). To investigate the influence of ultrasonic power on the extraction yield of TMP, in this study, the ultrasonic power was set at 60, 70, 80, 90, or 100 W while other parameters were set as follows: ultrasonic frequency, 45 kHz; ultrasonic time, 30 min; ultrasonic temperature, 70 °C; water to raw material ratio, 25 ml/g.…”

Section: Ultrasonic Powermentioning

confidence: 99%

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Ultrasound extraction optimization, structural features, and antioxidant activity of polysaccharides from Tricholoma matsutake

Chen

Zhang

et al. 2017

J. Zhejiang Univ. Sci. B

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Abstract:An ultrasonic-assisted technique was employed to extract crude polysaccharide from Tricholoma matsutake fruiting bodies. Single-factor tests and orthogonal experimental design (L 9 (3 3 )) were used to obtain the optimal extraction conditions. Results showed that the optimal parameters were as follows: ultrasonic temperature, 40 °C; ultrasonic time, 50 min; water to raw material ratio, 25 ml/g; ultrasonic frequency, 45 kHz; and ultrasonic power, 100 W. Three novel T. matsutake polysaccharide (TMP) fractions (TMP30, TMP60, and TMP80) were isolated and purified from TMP by stepwise alcohol precipitation. Their preliminary structural features were determined by highperformance anion-exchange chromatography with pulsed-amperometric detection (HPAEC-PAD) and Fourier transform infrared spectrophotometer (FT-IR) analyses. Furthermore, their in vitro antioxidant activity was investigated in terms of a reducing power assay and the scavenging rates of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals. The order of the various fractions based on their antioxidant activity was TMP80>TMP>TMP60>TMP30. These findings suggested that novel polysaccharide fractions from T. matsutake, especially TMP80, could be promising active macromolecules for biomedical use.

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Section: Ultrasonic Temperaturementioning

confidence: 93%

Section: Ft-ir Analysismentioning

confidence: 94%

Section: Ultrasonic Powermentioning

confidence: 99%

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Ultrasound extraction optimization, structural features, and antioxidant activity of polysaccharides from Tricholoma matsutake

Chen

Zhang

et al. 2017

J. Zhejiang Univ. Sci. B

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“…Plant polysaccharides are good sources of antioxidants. According to the report, three purified polysaccharides extracted from chuanxiong rhizome, LCX0, LCX1 and LCX2, exhibited strong antioxidant activities (Hu et al, 2016). Potatoe peel polysaccharide and arthrocnemum indicum leaf polysaccharide exhibited fairly strong cleaning capacities on DPPH and ABTS radicals in vitro (Jeddou et al, 2016;.…”

Section: Introductionmentioning

confidence: 99%

Optimization for the Extraction of Polysaccharide from Walnut (Juglans regia L.) Leaves: Antioxidant Activities in Vitro

Yang¹,

Xiao²,

Yu³

et al. 2019

American Journal of Biochemistry and Biotechnology

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Cellulase-assisted extraction of Walnut Leaf Polysaccharide (WLP) was studied. Single factor test and response surface design were employed to optimize the technological conditions. The consequences indicated that the highest WLP yield of 5.21% was achieved with raw material ratio of 50 mL/g, cellulase dose of 41488.52 U/g, enzymolysis pH of 5.88, enzymolysis time of 29.74 min and enzymolysis temperature of 52.07°C. Moreover, in vitro antioxidant assays revealed that WLP has significant eliminating capability against 1, 1-diphenyl-2-picrylhydrazyl (DPPH), 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and hydroxyl free radicals in a dose-dependent manner and exhibited a strong reducing power. These results suggest that WLP could be developed as a promising natural antioxidant agent in the pharmaceutical and functional food industries.

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“…At present, there is still no effective Western medicine for treatment. CX, a popular Chinese medicinal herb, has multiple beneficial therapeutic properties including antioxidation (Peng et al, ), anti‐inflammation (Choi et al, ; Zhu, Zhao, Wang, Gao, & Zhang, ) and neuroprotection (Kuang et al, ) and cardiovascular effects (Hu et al, ). It is a commonly used drug for invigorating blood circulation and eliminating stasis.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of ligustilide, dl‐3‐n‐butylphthalide and senkyunolide A in rat plasma by GC–MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction

Wang

Yan

Jiang

et al. 2019

Biomedical Chromatography

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The herb couple has special clinical significance in reducing the toxicity and increasing the efficacy of drugs. The combination of Radix Angelicae Dahuricae (Baizhi, BZ) andRhizoma Chuanxiong (ChuanXiong, CX) is a traditional herb couple. The combination performs better than the CX extract alone in the treatment of migraine and has been used for thousands of years. However, the specific compatibility mechanisms are still unclear. Ligustilide, DL-3-n-butylphthalide and senkyunolide A are the major active ingredients in CX and BZ-CX decoction. However, a comprehensive study of the pharmacokinetics of CX has not been carried out. A gas chromatography-mass spectroscopy (GC-MS) method with high selectivity, sensitivity and accuracy was developed. An SH-Rxi-5Sil (30 m × 0.25 mm i.d., and 0.25 μm film thickness) column was employed in the GC separation. Selectivity, linearity, precision, accuracy, recovery, matrix effect and stability were used to validate the current GC-MS method. Using the validated method, this is the first time to study on the comparative pharmacokinetics of ligustilide, DL-3-n-butylphthalide and senkyunolide A from CX alone and BZ-CX decoction in rat plasma. The pharmacokinetic parameters (C max , T max , T 1/2 , AUC 0-t , AUC 0-∞ and CLz/ F ) of all of the detected ingredients showed significant differences between the two groups (P < 0.05). The results are helpful for further investigation of the compatibility mechanism of BZ-CX decoction.

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Ultrasonic extraction, antioxidant and anticancer activities of novel polysaccharides from Chuanxiong rhizome

Cited by 74 publications

References 26 publications

Ultrasound extraction optimization, structural features, and antioxidant activity of polysaccharides from Tricholoma matsutake

Ultrasound extraction optimization, structural features, and antioxidant activity of polysaccharides from Tricholoma matsutake

Optimization for the Extraction of Polysaccharide from Walnut (Juglans regia L.) Leaves: Antioxidant Activities in Vitro

Simultaneous quantification of ligustilide, dl‐3‐n‐butylphthalide and senkyunolide A in rat plasma by GC–MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction

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