Ultrasonic Evaluation of Early Atherosclerosis in Children and Adolescents with Type 1 Diabetes Mellitus

Abstract

This study indicates that there is no association between T1DM and IMT in children and adolescents with T1DM.

Increased intima-media thickness of the carotid artery in childhood: a systematic review of observational studies

“…The evidence was weaker in IDDM. Besides the site of the cIMT measurement and a lack of statistical significance related to a small sample size [117,118], it is likely that this was in part related to the short median duration of the disease [34, 91,118], the young age of the patients, a good metabolic control of the disease, and the absence of complications in all but one study [29]. Indeed, cIMT was significantly higher in diabetics with complications than in diabetics without [29,49] or in controlled diabetics with another risk factor such as prehypertension [88].…”

Early onset of subclinical atherosclerosis in young persons with type 1 diabetes

“…Our findings support previous work regarding the early onset of atherosclerosis in adolescents and young adults with diabetes 8,9,26,27 and is in contrast to others who have not found a difference in carotid IMT in younger patients (3 to 18 years of age) with type 1 diabetes. 28 Despite the added burden of diabetes on atherosclerosis and significantly higher levels of certain lipids, young women with diabetes had thinner carotid IMT than did their male counterparts.…”

Early Diabetes-Related Complications in Adolescents

“…These clinical outcomes are preceded by changes in the structure and function of the arteries as measured by arterial compliance, distensibility and intima-media thickness (IMT) [70, 71]. Studies of both carotid artery and cardiac structure and function in adolescents with type 1 diabetes vary from normal findings to minor changes in carotid distensibility and compliance to significant differences in IMT [12, 72, 73]. Only Jarvisalo et al [73] reported significantly greater IMT in peripubertal children with type 1 diabetes compared to controls.…”