The Thermophysical parameters of densities(ρ), viscosities(η), refractive indices(nD) and the Excess properties such as Excess molar volume (V E ), Excess viscosity(η E ), deviation of refractive index(ΔnD), Excess molar refraction (Rm E ), Excess Gibbs free energy(ΔG* E ) were calculated for the binary mixture of 1-Pentanol and Cyclopentyl methyl ether at 293.15K. The comparative study of theoretical mixing rule relations for the refractive index of liquids has been carried out. The data obtained from the binary mixture were calculated and the interaction parameters were fitted with Redlich -Kister Polynomial equation. The computed parameters were discussed on the basis of nature of molecular interactions.