Ultrasonic bone assessment: “The time has come”

Siffert, Robert S.; Kaufman, Jonathan J.

doi:10.1016/j.bone.2006.07.018

Cited by 60 publications

(34 citation statements)

References 44 publications

(53 reference statements)

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“…Despite this, several studies have demonstrated high levels of correlation between heel trabecular sound transmission and aBMD at matched skeletal sites [48][49][50]. Moreover, both SOS and BUA, standard QUS measurements, are dependent on overall bone strength which, in turn, is related to bone density, architecture and turnover, and the extent of bone mineralization [48,50,[51][52][53][54][55][56]. These factors likely work together to maintain the overall quality and strength of bone and to prevent fractures and other bone failure.…”

Section: Quantitative Ultrasound (Qus) Bone Assessment Methodsmentioning

confidence: 99%

Ex Vivo and In Vivo Assessment of Vertebral Strength and Vertebral Fracture Risk Assessed by Dual Energy X-Ray Absorptiometry

Imai¹

2012

Dual Energy X-Ray Absorptiometry

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Section: Quantitative Ultrasound (Qus) Bone Assessment Methodsmentioning

confidence: 99%

Ex Vivo and In Vivo Assessment of Vertebral Strength and Vertebral Fracture Risk Assessed by Dual Energy X-Ray Absorptiometry

Imai¹

2012

Dual Energy X-Ray Absorptiometry

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“…In particular, quantitative ultrasound has been considered as an attractive alternative to the use of Dual Energy X-Ray Absorptiometry (DEXA) to diagnose osteoporosis (Siffert and Kaufman, 2006;Hans et al, 1996;Grimm and Williams, 1997a) because it is non-ionizing, inexpensive, and non-invasive. Ultrasound waves are elastic vibrations that can provide direct information on the mechanical properties of the medium in which they propagate.…”

Section: Introductionmentioning

confidence: 99%

Fabric dependence of quasi-waves in anisotropic porous media

Cardoso

Cowin

2011

The Journal of the Acoustical Society of America

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Assessment of bone loss and osteoporosis by ultrasound systems is based on the speed of sound and broadband ultrasound attenuation of a single wave. However, the existence of a second wave in cancellous bone has been reported and its existence is an unequivocal signature of poroelastic media. To account for the fact that ultrasound is sensitive to microarchitecture as well as bone mineral density (BMD), a fabric-dependent anisotropic poroelastic wave propagation theory was recently developed for pure wave modes propagating along a plane of symmetry in an anisotropic medium. Key to this development was the inclusion of the fabric tensor-a quantitative stereological measure of the degree of structural anisotropy of bone-into the linear poroelasticity theory. In the present study, this framework is extended to the propagation of mixed wave modes along an arbitrary direction in anisotropic porous media called quasi-waves. It was found that differences between phase and group velocities are due to the anisotropy of the bone microarchitecture, and that the experimental wave velocities are more accurately predicted by the poroelastic model when the fabric tensor variable is taken into account. This poroelastic wave propagation theory represents an alternative for bone quality assessment beyond BMD.

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“…110,112,[114][115][116][117][118][119][120][121] These factors likely work together to maintain overall bone quality and strength, and to prevent fractures and other bone failure. 110,112,[114][115][116][117][118][119][120][121] QUS parameters related to heel trabecular transverse transmission are highly correlated with bone strength. 117,[122][123][124][125][126][127][128][129] Consequently, it is conceivable that guidelines could be created using QUS to guide when to initiate osteoporosis treatment, Currently, a World Health Organization (WHO) task force is developing a model to predict the 10-year probability of osteoporosis-related fractures, combining femoral neck DXA BMD measurements and CRF.…”

Section: ) Using Qus To Initiate Osteoporosis Treatmentmentioning

confidence: 99%

“…Despite this, several studies have demonstrated high levels of correlation (r ~ 0.90) between heel trabecular sound transmission and BMD at matched skeletal sites. [110][111][112][113] Moreover, both SOS and BUA, standard QUS measurements, are dependent upon overall bone strength which, in turn, is related to bone density, architecture and turnover, and the extent of bone mineralization. 110,112,[114][115][116][117][118][119][120][121] These factors likely work together to maintain overall bone quality and strength, and to prevent fractures and other bone failure.…”

Section: ) Using Qus To Initiate Osteoporosis Treatmentmentioning

confidence: 99%

“…[110][111][112][113] Moreover, both SOS and BUA, standard QUS measurements, are dependent upon overall bone strength which, in turn, is related to bone density, architecture and turnover, and the extent of bone mineralization. 110,112,[114][115][116][117][118][119][120][121] These factors likely work together to maintain overall bone quality and strength, and to prevent fractures and other bone failure. 110,112,[114][115][116][117][118][119][120][121] QUS parameters related to heel trabecular transverse transmission are highly correlated with bone strength.…”

Section: ) Using Qus To Initiate Osteoporosis Treatmentmentioning

confidence: 99%

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Quantitative ultrasound for the detection and management of osteoporosis

Hans¹,

Krieg²

2009

Salud pública Méx

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Quantitative ultrasound (QUS) appears to be developing into an acceptable, low-cost and readily-accessible alternative to dual X-ray absorptiometry (DXA) measurements of bone mineral density (BMD) in the detection and management of osteoporosis. Perhaps the major difficulty with their widespread use is that many different QUS devices exist that differ substantially from each other, in terms of the parameters they measure and the strength of empirical evidence supporting their use. But another problem is that virtually no data exist outside of Caucasian or Asian populations. In general, heel QUS appears to be most tested and most effective. Some, but not all heel QUS devices are effective assessing fracture risk in some, but not all populations, the evidence being strongest for Caucasian females > 55 years old, though some evidence exists for Asian females > 55 and for Caucasian and Asian males > 70. Certain devices may allow to estimate the likelihood of osteoporosis, but very limited evidence exists supporting QUS use during the initiation or monitoring of osteoporosis treatment. Likely, QUS is most effective when combined with an assessment of clinical risk factors (CRF); with DXA reserved for individuals who are not identified as either high or low risk using QUS and CRF. However, monitoring and maintenance of test and instrument accuracy, ResumenEl ultrasonido cuantitativo (QUS) es una alternativa para la detección y manejo de la osteoporosis de bajo costo y uso práctico, si se compara con las densitometrías de rayos X de doble haz de baja energía (DXA) que determinan densidad mineral ósea (BMD). La mayor dificultad para el uso generalizado del QUS por un lado es que existen muchos instrumentos que son significativamente diferentes uno del otro y por otro en la calidad de la evidencia en que se justifica su empleo, que generalmente es insuficiente y/o poco sistematizada. Otro problema importante del QUS, es que prácticamente no existe información que no sea la generada en poblaciones asiáticas o caucásicas. En general, los estudios de calcáneo realizados con QUS son los más utilizados y mejor validados para evaluar el riesgo de fracturas en algunas poblaciones. La evidencia más grande de su efectividad se conoce para las mujeres caucásicas y asiáticas mayores de 55 años e incluso para los hombres asiáticos mayores de 70 años. Varios instrumentos cuentan con buen sustento científico, que los vuelve confiables para establecer un pronóstico preciso e identificar el riesgo individual de sufrir fracturas por osteoporosis, sin embargo, existe poca evidencia que respalde su uso para iniciar y monitorear el resultado del tratamiento de la osteoporosis. El QUS mejora su efectividad diagnóstica cuando se combina

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Ultrasonic bone assessment: “The time has come”

Cited by 60 publications

References 44 publications

Ex Vivo and In Vivo Assessment of Vertebral Strength and Vertebral Fracture Risk Assessed by Dual Energy X-Ray Absorptiometry

Ex Vivo and In Vivo Assessment of Vertebral Strength and Vertebral Fracture Risk Assessed by Dual Energy X-Ray Absorptiometry

Fabric dependence of quasi-waves in anisotropic porous media

Quantitative ultrasound for the detection and management of osteoporosis

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