Ultrasonic atomisation into reduced pressure atmosphere—envisaging aseptic spray-drying for microencapsulation

Freitas, Sergio; Merkle, Hans P.; Gander, Bruno

doi:10.1016/j.jconrel.2003.11.005

Cited by 90 publications

(47 citation statements)

References 21 publications

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“…[146][147][148] Moreover, the spray-drying system can be modified to meet specific needs. For example, Maa and colleagues 149 replaced the bag-filter unit of a spray-drying system with a vacuum to reduce the drying airflow resistance.…”

Section: Spray-dryingmentioning

confidence: 99%

“…146 In another study, poly(lactic-co-glycolic acid) particles containing proteins were successfully dried by ultrasonic atomization of feed solution into an atmosphere under reduced pressure. 147 Solution spray-drying ensures compositional homogeneity of the drug powder, since the drug and the excipients are dissolved prior to the process. More importantly, spray-drying can result in uniform particle morphology.…”

Section: Spray-dryingmentioning

confidence: 99%

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Nanomedicine in pulmonary delivery

Mansour¹,

Rhee²,

Wu³

2009

IJN

405

269

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Section: Spray-dryingmentioning

confidence: 99%

Section: Spray-dryingmentioning

confidence: 99%

Nanomedicine in pulmonary delivery

Mansour¹,

Rhee²,

Wu³

2009

IJN

405

269

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“…This technique involves evaporation from an atomized feed by mixing the spray and the drying medium. The complete process consists basically of a sequence of four steps: atomization, mixing of spray and air, evaporation, and product separation [1][2][3][4] . Due to rapid solvent evaporation, the temperature of the droplets can be kept far below the drying air temperature; for this reason, spray drying can be applied to both heat-resistant and heat-sensitive materials 5 .…”

Section: Introductionmentioning

confidence: 99%

A low-cost ultrasonic spray dryer to produce spherical microparticles from polymeric matrices

Luz¹,

Pires²,

Serra³

2007

Quím. Nova

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Recebido em 5/4/06; aceito em 10/11/06; publicado na web em 29/8/07The spray-drying technique has been widely used for drying heat-sensitive foods, pharmaceuticals, and other substances, because it leads to rapid solvent evaporation from droplets. This method involves the transformation of a feed from a fluid state into a dried particulate, by spraying the feed into a hot medium. Despite being most often considered a dehydration process, spray drying can also be used as an encapsulation method. Therefore, this work proposes the use of a simple and low-cost ultrasonic spray dryer system to produce spherical microparticles. This equipment was successfully applied to the preparation of dextrin microspheres on a laboratory scale and for academic purposes.

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“…The complete process consists basically of a sequence of four steps: atomization, mixing of spray and air, evaporation, and product separation (Makai et al 2008, Luz et al 2007, Freitas et al 2004). …”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of hydroxyapatite-coated iron oxide particles by spray-drying technique

Donadel

Felisberto

Laranjeira

2009

An. Acad. Bras. Ciênc.

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Magnetic particles of iron oxide have been increasingly used in medical diagnosis by magnetic resonance imaging and in cancer therapies involving targeted drug delivery and magnetic hyperthermia. In this study we report the preparation and characterization of iron oxide particles coated with bioceramic hydroxyapatite by spray-drying. The iron oxide magnetic particles (IOMP) were coated with hydroxyapatite (HAp) by spray-drying using two IOMP/HAp ratios (0.7 and 3.2). The magnetic particles were characterized by way of scanning electronic microscopy, energy dispersive X-ray, X-ray diffraction, Fourier transformed infrared spectroscopy, flame atomic absorption spectrometry, vibrating sample magnetometry and particle size distribution (laser diffraction). The surface morphology of the coated samples is different from that of the iron oxide due to formation of hydroxyapatite coating. From an EDX analysis, it was verified that the surface of the coated magnetic particles is composed only of HAp, while the interior contains iron oxide and a few layers of HAp as expected. The results showed that spray-drying technique is an efficient and relatively inexpensive method for forming spherical particles with a core/shell structure.

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Ultrasonic atomisation into reduced pressure atmosphere—envisaging aseptic spray-drying for microencapsulation

Cited by 90 publications

References 21 publications

Nanomedicine in pulmonary delivery

Nanomedicine in pulmonary delivery

A low-cost ultrasonic spray dryer to produce spherical microparticles from polymeric matrices

Preparation and characterization of hydroxyapatite-coated iron oxide particles by spray-drying technique

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