Ultrasonic-assisted-synthesis of isoindolin-1-one derivatives

Abstract

Functionalized isoindolin-1-ones have been prepared in short reaction time and excellent yields from 3-alkylidenephtalides and primary amines under ultrasonic irradiation.

Ultrasound-assisted-one-pot synthesis and antiplasmodium evaluation of 3-substituted-isoindolin-1-ones

“…The one-pot synthesis of 3-substituted-isoindolin-1-ones 1 was initially investigated by performing the nucleophilic addition reaction between ( Z )-3-benzylideneisobenzofuran-1(3 H )-one 2a (prepared from 2-iodobenzoic acid and terminal alkynes via ultrasound-assisted-Sonogashira coupling 27 ) and butylamine 3a in iso-propanol at 50 °C under ultrasound irradiation. This reaction in situ produced the synthetic intermediate of 3-hydroxyisoindolin-1-ones 7 .…”

“…We also found that ultrasound irradiation may accelerate the rate of those reactions. 27 Our strategy was driven to meet the green chemistry principles as an efficient approach for 3-isoindolin-1-ones 1. Based on the promising preliminary results, we envisioned that performing both reactions based on ultrasound-assisted-one-pot reaction would efficiently generate 3-isoindolin-1-ones 1.…”

Ultrasonic irradiation-assisted MnFe2O4 nanoparticles catalyzed solvent-free selective oxidation of benzyl alcohol to benzaldehyde at room temperature

“…The reason behind the enhanced conversion under ultrasonic irradiation might be the cavitation phenomenon caused by ultrasonic irradiation which may supply energy to the reaction medium by creating a repeating pattern of compressions and rarefaction. 53,54 This results in an increase in the rate of the reaction and the yield. Further, it is obvious from Table 3 that the catalyst synthesized in the presence of additives offers higher catalytic activity which might be due to the different surface properties of the particles in different samples.…”

Synthesis of New Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via an Ugi-Zhu/Cascade/Click Strategy

“…Finally, the pyrrolo[3,4- b ]pyridin-5-one is a fused-type bis -heterocycle that is also of high interest in medicinal chemistry. It includes the antidiabetic agent BMS-767778 ( 3 , Figure 1 ) [ 9 ] which is an N- sp 2 -containing surrogate of the naturally occurring isoindolin-1-one ( 3′ , Figure 1 ) [ 10 ]. The pyrrolo[3,4- b ]pyridin-5-one system is very special in our research group.…”