Ultrasonic assessment of human and bovine trabecular bone: a comparison study

Alves, José Marcos; Xu, Wei; Lin, Dao‐Hong; Siffert, Robert S.; Ryaby, James T.; Kaufman, Jonathan J.

doi:10.1109/10.486282

Cited by 52 publications

(25 citation statements)

References 22 publications

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“…In vitro experiments found high correlations between bone mechanical indices, such as the hardness of the bone and the indent depth of bone cores, with ultrasound measurements [5][6][7][8]. Measurement of bovine bone core samples demonstrated high correlation between QUS parameters and X-ray densitometry [9]. Subsequent cross-sectional studies in humans confirmed this relation between the broadband ultrasound attenuation (BUA), which is the attenuation of the sound wave as it passes through the bone, BMD as measured by DXA.…”

Section: Introductionmentioning

confidence: 84%

Quantitative Ultrasound and Symptomatic Vertebral Fracture Risk in Chinese Women

Kung

Luk

Chu

et al. 1999

Osteoporosis International

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Quantitative ultrasound (QUS) is emerging as a simple, inexpensive and noninvasive method for assessing bone quality and assessing fracture risk. We assessed the usefulness of a contact calcaneal ultrasonometer by studying normal premenopausal women (group I, n = 53), normal postmenopausal women (group II, n = 198), and osteoporotic women without (group III, n = 141) and with vertebral fractures (group IV, n = 53). The osteoporotic subjects had a T-score of the spine or hip neck bone mineral density (BMD) <-2.5 based on the local Chinese peak young mean values. When compared with postmenopausal controls, mean broadband ultrasound attenuation (BUA), speed of sound (SOS), and quantitative ultrasound index (QUI) were 26%, 2.1% and 25% lower in women with vertebral fractures (p all <0.005). The correlation coefficients between QUS parameters and BMD of the spine and hip ranged between 0.4 and 0.5. The ability of the QUS to discriminate between patients groups was determined based on the mean value of normal premenopausal women in group I. The mean T-score for women with fractures was -2.87 +/- 1.02 for BUA, -2.54 +/- 0.79 for SOS, -3.17 +/- 0.70 for QUI, -2.65 +/- 0.86 for L2-4 BMD and -2.53 +/- 0.66 for hip neck BMD. After adjustment for age and body mass index, the odds ratio of vertebral fracture was 1.71 (95% CI 1.2-2.6) for each 1 SD reduction in BUA, 2.72 (1.3-5.3) for SOS, 2.58 (1.4-4.6) for QUI, 2.33 (1.6-3.3) for L2-4 BMD, 2.09 (1. 37-3.20) for femoral neck BMD and 1.88 (1.34-2.92) for total hip BMD. The association between the QUS parameters and vertebral fracture risk persisted even adjustment for BMD. The area under the receiver operating characteristic curve for BUA for vertebral fracture was 0. 92, for SOS, QUI, L2-4 BMD and femoral neck BMD was 0.95, and for total hip was 0.91.

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Section: Introductionmentioning

confidence: 84%

Quantitative Ultrasound and Symptomatic Vertebral Fracture Risk in Chinese Women

Kung

Luk

Chu

et al. 1999

Osteoporosis International

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“…There is growing interest in the use of quantitative ultrasound (QUS) in the diagnosis and management of osteoporosis. Initial assessment believed that QUS measured bone structure and bone quality [3][4][5], but there is mounting evidence to show that QUS primarily reflects bone density [6][7][8][9]. There is a high correlation found between in vivo QUS measurements and heel bone mineral density (BMD) measured by dualenergy X-ray absorptiometry (DXA) [9].…”

Section: Introductionmentioning

confidence: 98%

Evaluation of a New Calcaneal Quantitative Ultrasound System and Determination of Normative Ultrasound Values in Southern Chinese Women

Kung¹,

Tang²,

Luk

et al. 1999

Osteoporosis International

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Quantitative ultrasound (QUS) assessment at the calcaneus has been found to be a safe and reliable method for evaluating skeletal status. The present study aimed at evaluating the precision of the Sahara bone ultrasound densitometer and to determine the normative QUS data in healthy southern Chinese women. Broadband ultrasound attenuation (BUA), speed of sound (SOS) and qualitative ultrasound index (QUI) were determined. The long-term in vitro precision of the Sahara machine over 6 months was 4.6% for BUA and 0.39% for SOS. The short-term in vivo precision was 3.2 ± 1.3% for BUA, 0.3 ± 0.2% for SOS and 1.8 ± 1.0% for QUI. The standardized precision for BUA, SOS and QUI was 4.4, 3.8 and 2.2 respectively. The normative data were determined in 1086 healthy subjects. Postmenopausal women had significantly lower BUA, SOS and QUI levels than the premenopausal women. Significant negative correlations were observed between QUS indices and age. Bone mineral density (BMD) assessments was performed on 349 of these subjects. BUA correlated significantly with lumbar spine BMD (r = 0.326) and femoral neck BMD (r = 0.395). Similar correlations were observed between SOS, QUI and BMD, with r values ranging between 0.446 to 0.522. Despite the fact that Chinese women have significantly lower BMD values than Caucasian women, the mean BUA values for pre-and postmenopausal Chinese women (73 ± 18 and 59 ± 18 dB/MHz respectively) were almost the same as those reported for Caucasian women. These normative data will be useful in the assessment of southern Chinese women with fracture risk.

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“…3 In contrast, several studies reported the nonlinear relationship between the attenuation and the bone mineral density (BMD) over a wide range of BMD. 13,14 For instance, Alves et al observed a positive correlation between the nBUA and the BMD in relatively low density human trabecular bone samples (0.057-0.142 gcm -3 ) and a negative correlation in higher density bovine samples (0.190-0.450 gcm -3 ). 13 Comparison of the present study with the works discussed in the preceding text is complicated by the fact that they used the BMD while the present study used the apparent bone density.…”

Section: Methodsmentioning

confidence: 96%

“…13,14 For instance, Alves et al observed a positive correlation between the nBUA and the BMD in relatively low density human trabecular bone samples (0.057-0.142 gcm -3 ) and a negative correlation in higher density bovine samples (0.190-0.450 gcm -3 ). 13 Comparison of the present study with the works discussed in the preceding text is complicated by the fact that they used the BMD while the present study used the apparent bone density. Figure 3 shows the average backscatter coefficient as a function of the frequency for the 25 bone samples.…”

Section: Methodsmentioning

confidence: 96%

Frequency-dependent attenuation and backscatter coefficients in bovine trabecular bone from 0.2 to 1.2 MHz

Lee¹,

Choi²

2011

The Journal of the Acoustical Society of America

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The frequency-dependent attenuation and backscatter coefficients were measured in 25 bovine femoral trabecular bone samples from 0.2 to 1.2 MHz. When the average attenuation coefficient was fitted to a nonlinear power law α(f)=α(0)+α(1)f(n), the exponent n was found to be 1.65. In contrast, the average backscatter coefficient was fitted to a power law η(f)=η(1)f(n) and the exponent n was measured as 3.25. The apparent bone density was significantly correlated with the parameter α(1) (0.2-0.7 MHz: r = 0.852, 0.6-1.2 MHz: r = 0.832) as well as the backscatter coefficient (0.5 MHz: r = 0.751, 1.0 MHz: r = 0.808).

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Ultrasonic assessment of human and bovine trabecular bone: a comparison study

Cited by 52 publications

References 22 publications

Quantitative Ultrasound and Symptomatic Vertebral Fracture Risk in Chinese Women

Quantitative Ultrasound and Symptomatic Vertebral Fracture Risk in Chinese Women

Evaluation of a New Calcaneal Quantitative Ultrasound System and Determination of Normative Ultrasound Values in Southern Chinese Women

Frequency-dependent attenuation and backscatter coefficients in bovine trabecular bone from 0.2 to 1.2 MHz

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