Ultrasonic accelerated Knoevenagel condensation by magnetically recoverable MgFe2O4 nanocatalyst: A rapid and green synthesis of coumarins under solvent-free conditions

Safaei‐Ghomi, Javad; Akbarzadeh, Zeinab

doi:10.1016/j.ultsonch.2017.06.022

Cited by 73 publications

(26 citation statements)

References 37 publications

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“…One of the novel methodologies that attract significant attention in biocatalyzed esterification reactions is the use of ultrasonic systems, alternative greener processes with high yields, and a greater selectivity as compared to other methodologies (Adak and Banerjee, 2016 ; Gupta S. et al, 2017 ; Gupta S. M. et al, 2017 ; Javad Safaei Ghomi, 2018 ). By comparison with conventional heating in carousel reactors, where mass transfer in esterification reactions is very limited, acoustic cavitation, and ultrasound hydrodynamics can solve mass transfer limitations at short times of reaction (Singh et al, 2007 ; Mahamuni and Adewuyi, 2009 ; Thanh le et al, 2010 ; Batistella et al, 2012 ; Veljković et al, 2012 ; Bhangu et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Esterification of Valeric Acid to Alkyl Valerates Promoted by Biosilicified Lipases

2018

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A novel, environmentally friendly, and sustainable ultrasound-assisted methodology in the valorization of valeric acid to alkyl valerate using a biosilicified lipase from Candida antarctica is reported. This one-pot room temperature methodology of enzyme biosilicification leads to biosilicified lipases with improved activity and reaction efficiency as compared to free enzymes. Yields in the ultrasound-promoted esterification of valeric acid was ca. 90% in 2 h with 15% m/v of biosilicified lipase (Bio-lipase; 616 U/g biocatalyst enzymatic activity) and a molar ratio 1:2 (valeric acid:ethanol), slightly superior to that observed by the free enzyme (75% conversion, 583U/g biocatalyst enzymatic activity). The reuse of enzymes in these conditions was tested and the results show a relatively good reusability of these biosilicified enzymes under the investigated conditions, particularly preserving fairly stable specific activities (616 vs. 430 U/g biocatalyst after four reuses).

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Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Esterification of Valeric Acid to Alkyl Valerates Promoted by Biosilicified Lipases

2018

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“…Essentially the main role of ultrasound irradiation is enhancement number of active cavitation bubbles and size of the individual bubbles. Both of which are expected to result in higher maximum collapse temperature and accelerated the synthesis of pyrimidines derivatives by the Biginelli‐Like reaction …”

Section: Resultsmentioning

confidence: 99%

Ultrasonic Accelerated Biginelli‐Like Reaction by the Covalently Anchored Copper‐Isatoic Anhydride over the Modified Surface of Mesoporous SBA‐15 to the Synthesis of Pyrimidines

Safaei‐Ghomi

Bakhtiari

2018

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The novel hybrid catalyst Cu@IA‐SBA‐15 was synthesized by anchoring isatoic anhydride on amino‐functionalized SBA‐15. The synthesized process pursued by grafting of Cu(II) to catch desired product. 2D‐hexagonally ordered mesoporous of bidentate ligand characterized by X‐ray diffraction spectroscopy (XRD), N2 adsorption analysis, Field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM), fourier‐transform infrared spectroscopy (FTIR), Energy‐dispersive X‐ray spectroscopy (EDX), and Thermogravimetric and differential thermal analysis (TGA‐DTA). The activity of catalyst has been scrutinized in Biginelli‐Like reaction through the environmentally benign conditions by using ultrasound irradiation and green solvents. The methodology offers remarkable development by easy production of hybrid catalyst Cu@IA‐SBA‐15 in regard to solve the problem of using harsh catalysts. It also demonstrates to be impressive and environmentally friendly in term of low reaction times and high yields.

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“…Knoevenagel condensation between various salicylaldehydes and 1,3-dicarbonyl compounds, by using MgFe 2 O 4 nanoparticles as an efficient catalyst under solvent-free conditions and ultrasound irradiation, has been reported [ 69 ]. High yields, simple work-up procedure and short reaction times are further advantages of the proposed protocol.…”

Section: Synthetic Strategies For the Preparation Of Coumarinsmentioning

confidence: 99%

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

et al. 2018

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Many naturally occurring substances, traditionally used in popular medicines around the world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal chemists, because of its peculiar physicochemical features, and the versatile and easy synthetic transformation into a large variety of functionalized coumarins. As a consequence, a huge number of coumarin derivatives have been designed, synthesized, and tested to address many pharmacological targets in a selective way, e.g., selective enzyme inhibitors, and more recently, a number of selected targets (multitarget ligands) involved in multifactorial diseases, such as Alzheimer’s and Parkinson’s diseases. In this review an overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations. The many existing and recent reviews in the field prompted us to make some drastic selections, and therefore, the review is focused on monoamine oxidase, cholinesterase, and aromatase inhibitors, and on multitarget coumarins acting on selected targets of neurodegenerative diseases.

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Ultrasonic accelerated Knoevenagel condensation by magnetically recoverable MgFe2O4 nanocatalyst: A rapid and green synthesis of coumarins under solvent-free conditions

Cited by 73 publications

References 37 publications

Ultrasound-Assisted Esterification of Valeric Acid to Alkyl Valerates Promoted by Biosilicified Lipases

Ultrasound-Assisted Esterification of Valeric Acid to Alkyl Valerates Promoted by Biosilicified Lipases

Ultrasonic Accelerated Biginelli‐Like Reaction by the Covalently Anchored Copper‐Isatoic Anhydride over the Modified Surface of Mesoporous SBA‐15 to the Synthesis of Pyrimidines

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

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