Ultrasmall zirconium carbide nanodots for synergistic photothermal-radiotherapy of glioma

Yin, Mengyuan; Chen, Xiangcun; Guo, Qinglong; Liang, Xiao; Gao, Peng; Zang, Dandan; Dong, Jun; Zha, Zhengbao; Wang, Xianwen

doi:10.1039/d2nr04239h

Cited by 21 publications

(9 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liquid-phase exfoliation is usually conducted by sonifying the material in an appropriate solvent and is a simple top-down approach to the production of numerous nanomaterials. − Additionally, this liquid-phase exfoliation is an efficient method for synthesizing different types of metal compound nanomaterials, including TiH 1.924 and TiN. , The synthesis process of TiO NSs was primarily realized by liquid-phase ultrasonic exfoliation technology (Figure a). TEM images demonstrated that the TiO NSs were irregularly dispersed nanosheet structures, with an average diameter of approximately 50 nm (Figure b–e).…”

Section: Resultsmentioning

confidence: 99%

Injectable Hydrogel Containing TiO Nanosheets for Synergistic Photothermal/Thermodynamic Therapy

Xing,

Yang,

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Tumors have become the biggest obstacle to human health, and there are various treatment methods at present. Photothermal therapy (PTT) is usually ineffective and does not inhibit tumor progression due to the inability of the lasers to penetrate deeply. Therefore, most existing studies chose a 1064 nm laser with stronger penetrating power; meanwhile, studies have shown that the inclusion of harmful free radicals can significantly improve the antitumor efficacy. Herein, TiO nanosheets (NSs) were creatively prepared and encapsulated with an alkyl radical generator {2,2′-azobis[2-(2-imidazoline-2-yl)propane] dihydrochloride, [AIPH]} in sodium alginate (ALG) hydrogel for effective tumor killing by PTT and pairing with dangerous free radicals. TiO NSs were obtained by the liquid-phase exfoliation method, together with AIPH, which were in situ coencapsulated multifunctional hydrogels formed by the combination of Ca 2+ and ALG. This ALG hydrogel could enrich TiO NSs and AIPH at the tumor site for a long time, and through the excellent photothermal properties of TiO NSs, AIPH could slowly and effectively generate alkyl radicals at the tumor site, which, in turn, gave it a better antitumor effect compared with that of TiO NSs in the deep hypoxic environment of the tumor. The AIPH + TiO + ALG hydrogel has distinctive anticancer capabilities based on the results of both in vivo and in vitro experiments. This material also has good biosafety. By combining PTT and free radical treatment, this work provides a novel therapeutic method to achieve oxygen-independent free radical production and enhance therapeutic efficacy.

show abstract

Section: Resultsmentioning

confidence: 99%

Injectable Hydrogel Containing TiO Nanosheets for Synergistic Photothermal/Thermodynamic Therapy

Xing,

Yang,

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

show abstract

“…To resolve the excess ROS problems caused by PPT, Xianwen Wang and his colleagues designed ultrasmall ZrC NDs, which eliminates ROS to decrease inflammation caused by PTT treatment for glioma ( 92 ). Subsequently, ultrasmall ZrC–PVP nanodots (NDs) (ZrC–PVP NDs) based on the combination of PTT–RT photothermal therapy (PTT) -Radiation therapy (RT) was designed for glioma treatment ( 93 ). Furthermore, they attempted to disrupt the respiration process and modify the oxidation state of cancer cells by continuously generating H 2 through the transfer of MgG rods into the cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to cancer immunity and immunotherapy

et al. 2023

View full text Add to dashboard Cite

BackgroundIn the past 5 years, ferroptosis-associated cancer immunity has been attracted significant research interest.ObjectiveThis study was performed to identify and analyze the global output trend for ferroptosis in cancer immunity.MethodsRelevant studies were retrieved from the Web of Science Core Collection on Feb 10th, 2023. The VOSviewer and Histcite softwares were utilized to perform the visual bibliometric and deep mining analyses.ResultsA total of 694 studies (530 articles (76.4%) and 164 (23.6%) review articles) were retrieved from the Web of Science Core Collection for visualization analyses. The top 3 key keywords were ferroptosis, prognosis and immunotherapy. The top 30 local citation score (LCS) authors were all collaborators of Zou Weiping. Deep mining of 51 nanoparticle-related articles showed that BIOMATERIALS was the most popular journal. The primary goal of gene signatures related to ferroptosis and cancer immunity was to establish prognostic predictions.ConclusionThere has been a significant increase in ferroptosis-associated immune publications in the recent 3 years. The key research hotspots include mechanisms, prediction and therapeutic outcomes. The most influential article was from the Zou Weiping’s group, which proposed that system xc-mediated ferroptosis is induced by CD8(+) T cell-secreted IFNγ after PD-L1 blockage for immunotherapy. The frontier of research in the field of ferroptosis-associated immune is the study on nanoparticle and gene signature The limitation of this bibliometric study is that publications on this topic are few.

show abstract

“…Additionally, there exists hypoxia in most solid tumors while oxygen is essential to enhance radiation-induced DNA damage, hence the tumor hypoxia-associated radiation resistance is another mechanism that limits the radiotherapy effectiveness ( 56 – 58 ). In conjunction with the advancement in nanotechnology, nanomedicine strategies will hopefully be used to enhance tumor radiation responses and overcome radio resistance ( 59 – 62 ).…”

Section: Nanotechnology-based Therapeutics For Lung Cancermentioning

confidence: 99%

Advanced diagnostic and therapeutic strategies in nanotechnology for lung cancer

et al. 2022

View full text Add to dashboard Cite

As a highly invasive thoracic malignancy with increasing prevalence, lung cancer is also the most lethal cancer worldwide due to the failure of effective early detection and the limitations of conventional therapeutic strategies for advanced-stage patients. Over the past few decades, nanotechnology has emerged as an important technique to obtain desired features by modifying and manipulating different objects on a molecular level and gained a lot of attention in many fields of medical applications. Studies have shown that in lung cancer, nanotechnology may be more effective and specific than traditional methods for detecting extracellular cancer biomarkers and cancer cells in vitro, as well as imaging cancer in vivo; Nanoscale drug delivery systems have developed rapidly to overcome various forms of multi-drug resistance and reduce detrimental side effects to normal tissues by targeting cancerous tissue precisely. There is no doubt that nanotechnology has the potential to enhance healthcare systems by simplifying and improving cancer diagnostics and treatment. Throughout this review, we summarize and highlight recent developments in nanotechnology applications for lung cancer in diagnosis and therapy. Moreover, the prospects and challenges in the translation of nanotechnology-based diagnostic and therapeutic methods into clinical applications are also discussed.

show abstract

Ultrasmall zirconium carbide nanodots for synergistic photothermal-radiotherapy of glioma

Abstract: Glioma is characterized by highly invasive, progressive, and lethal features. In addition, conventional treatments have been poorly effective in treating glioma. To overcome this challenge, synergistic therapies combining radiotherapy (RT)...

Cited by 21 publications

References 61 publications

Injectable Hydrogel Containing TiO Nanosheets for Synergistic Photothermal/Thermodynamic Therapy

Injectable Hydrogel Containing TiO Nanosheets for Synergistic Photothermal/Thermodynamic Therapy

Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to cancer immunity and immunotherapy

Advanced diagnostic and therapeutic strategies in nanotechnology for lung cancer

Contact Info

Product

Resources

About