Ultrasmall, Water-Soluble Magnetite Nanoparticles with High Relaxivity for Magnetic Resonance Imaging

Hu, Fengqin; MacRenaris, Keith W.; Waters, Emily A.; Liang, Taiyang; Schultz‐Sikma, Elise A.; Eckermann, Amanda L.; Meade, Thomas J.

doi:10.1021/jp907216g

Cited by 132 publications

(107 citation statements)

References 42 publications

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“…Up to now, many methods have been developed to prepare Fe 3 O 4 nanocrystals with small sizes on the nanometer scale, which include hydrothermal synthesis [9,10], chemical coprecipitation [11-13], and thermal decomposition and/or reduction [14,15]. Besides these nanosized particles, the secondary structural superparamagnetic Fe 3 O 4 particles have also attracted increasing attention due to their practical applications in magnetic separation and magnetic-targeted substrate delivery [16,17].…”

Section: Introductionmentioning

confidence: 99%

Ethylenediaminetetraacetic acid as capping ligands for highly water-dispersible iron oxide particles

Zhang

Wang

et al. 2014

Nanoscale Res Lett

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Monodispersed magnetite (Fe3O4) particles were synthesized using a high-temperature hydrolysis reaction with the assistance of ethylenediaminetetraacetic acid (EDTA) as capping ligands. These particles were composed of small primary nanocrystals and their sizes could be tuned from about 400 to about 800 nm by simply changing the EDTA or precursor concentration. Surface-tethered EDTA made the particles highly water-dispersible. The as-prepared magnetite particles also showed superparamagnetic behavior at room temperature, and their magnetic properties were size dependent. In addition, the particles had a strong response to external magnetic field due to their high magnetization saturation values. These properties were very important for some potential biomedical applications, such as magnetic separation and magnetic-targeted substrate delivery.

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Section: Introductionmentioning

confidence: 99%

Ethylenediaminetetraacetic acid as capping ligands for highly water-dispersible iron oxide particles

Zhang

Wang

et al. 2014

Nanoscale Res Lett

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“…Accelerating proton relaxation underlies the function of contrast agents used in magnetic resonance imaging (MRI). 19–36 Thus, a better elucidation of the mechanism of action of Gd(III)-carbon nanomaterials may provide an opportunity to increase the sensitivity of Gd(III) agents beyond what is currently accessible by Gd(III)-complexes.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Gadographene-Mediated Proton Spin Relaxation

Hung¹,

Duch²,

Parigi

et al. 2013

J. Phys. Chem. C

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Gd(III) associated with carbon nanomaterials relaxes water proton spins at an effectiveness that approaches or exceeds the theoretical limit for a single bound water molecule. These Gd(III)-labeled materials represent a potential breakthrough in sensitivity for Gd(III)-based contrast agents used for magnetic resonance imaging (MRI). However, their mechanism of action remains unclear. A gadographene library encompassing GdCl3, two different Gd(III)-complexes, graphene oxide (GO), and graphene suspended by two different surfactants and subjected to varying degrees of sonication was prepared and characterized for their relaxometric properties. Gadographene was found to perform comparably to other Gd(III)-carbon nanomaterials; its longitudinal (r1) and transverse (r2) relaxivity is modulated between 12–85 mM−1s−1 and 24–115 mM−1s−1, respectively, depending on the Gd(III)-carbon backbone combination. The unusually large relaxivity and its variance can be understood under the modified Florence model incorporating the Lipari-Szabo approach. Changes in hydration number (q), water residence time (τM), molecular tumbling rate (τR), and local motion (τfast) sufficiently explain most of the measured relaxivities. Furthermore, results implicated the coupling between graphene and Gd(III) as a minor contributor to proton spin relaxation.

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“…Parekh et al synthesized magnetite nano-fluid and reported that the thermal conductivity of fluid decreases linearly with increase in temperature [20]. Hu et al prepared magnetite nanocrystals via facile onepot reaction method and reported that the magnetite nanocrystals are good magnetic resonance agents for invivo and in-vitro applications [21]. Darken et al discussed in detail about the thermodynamics of the ironoxide system [22].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of magnetite nanocrystals

Raja

Verma

Karmakar

et al. 2011

Cryst. Res. Technol.

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Nanocrystals of magnetite (Fe 3 O 4 ) were prepared by sol-gel technique. The prepared nanocrystals were characterized for phase by powder X-ray diffraction (XRD) of the samples annealed at successively higher temperature. The magnetite phase was formed during the annealing of the synthesized powder at 400 °C for a few hours. The Fourier transform infrared spectroscopy (FTIR) was performed to analyze the functional groups in the material. The energy dispersive X-ray diffraction (EDAX) was performed for chemical composition analysis. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) techniques were used to analyze the morphology of nanocrystals and for estimating their average size. The results confirm the formation of Fe 3 O 4 nanocrystals of the sizes ~20-50 nm.

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Ultrasmall, Water-Soluble Magnetite Nanoparticles with High Relaxivity for Magnetic Resonance Imaging

Cited by 132 publications

References 42 publications

Ethylenediaminetetraacetic acid as capping ligands for highly water-dispersible iron oxide particles

Ethylenediaminetetraacetic acid as capping ligands for highly water-dispersible iron oxide particles

Mechanisms of Gadographene-Mediated Proton Spin Relaxation

Synthesis and characterization of magnetite nanocrystals

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