Ultrasmall Inorganic Mesoporous Nanoparticles: Preparation, Functionalization, and Application

Abstract

Ultrasmall mesoporous nanoparticles (< 50 nm), a unique porous nanomaterial, have been widely studied in the last decade owing to the abundant advantages, involving rich mesopores, low density, high surface area, numerous reaction sites, large cavity space, ultrasmall size, etc. It has been widely used in a range of applications, involving absorption, catalysis, energy storage, fluorescence imaging, and drug delivery/therapy. This paper presents a review of recent advances in the preparation, functionalization and applications of ultrasmall inorganic mesoporous nanoparticles for the first time. The soft monomicelles‐directed method, in contrast to the hard‐template and template‐free methods, is more flexible in the synthesis of mesoporous nanoparticles. This is because the amphiphilic micelle has tunable functional blocks, controlled molecule masses, and adjusted configurations and mesostructures. Focus on the soft micelle directing method, monomicelles could be classified into four types, i.e., the Pluronic‐type block copolymer monomicelles, laboratory‐synthesized amphiphilic block copolymers monomicelles, the single‐molecule star‐shaped block copolymer monomicelles, and the small‐molecule anionic/cationic surfactant monomicelles. This paper also reviews the functionalization of the inner mesopores and the outer surfaces, which includes constructing the yolk‐shell structures (encapsulated nanoparticles), anchoring the active components packed on the shell and building an asymmetric Janus architecture. Then, several representative applications, involving catalysis, energy storage, and biomedicines are presented. Finally, the prospects and challenges of controlled synthesis and large‐scale applications of ultrasmall mesoporous nanoparticles in the future are foreseen. This article is protected by copyright. All rights reserved

Ultrafine Asymmetric Soft/Stiff Nanohybrids with Tunable Patchiness via a Dynamic Surface-Mediated Assembly

“…Organic–inorganic nanohybrids have essential roles in various applications, for example, biomedicine, mechanics, optics and electronics due to the outstanding and fascinating properties. − Both the merits of the organic (like softness, flexibility, easy processing, facile tuning of optical and electrical properties) and inorganic constituents (e.g., hardness, high thermal stability and excellent charge-carrier mobility) can be inherited in a nanohybrid. − In biomedical field, such as cell uptake, lots of research works have proved that the organic–inorganic hybrid nanoparticles with different particle sizes and formulations have an important influence on their efficiency or activity. − This is because the size and the configuration of nanoparticles strongly impact their chemical and physical properties and further affect their actions in biological systems. − Also, the controlled synthesis of a desirable efficient hybrid nanoparticle is important on biomedical applications. , For the conventional organic–inorganic hybridation, there are two main forms: (i) homogeneous and (ii) core–shell type hybridization. , For the former, the organic and inorganic species are homogeneously mixed in a particle skeleton, resulting in a compromised property between the organics and inorganics. − For the latter, only the merit of the shell constituent can be inherited (because the core is shielded). − So, to overcome these inherent limitations of the two aforementioned hybrid forms, a new hybridation manner should be adopted.…”