Ultrasmall Gold-Coated Mesoporous Polydopamine Nanoprobe to Enhance Chemodynamic Therapy by Self-Supplying H₂O₂ and Photothermal Stimulation

Abstract

Tumor microenvironment (TME) responsive chemodynamic therapy (CDT) showed an important application in inhibiting tumor growth by producing the highly toxic hydroxyl radical (·OH), but insufficient hydrogen peroxide (H2O2) and overexpressed glutathione (GSH) limited its application. Herein, by integrating photothermal therapy (PTT) and CDT, a new kind of mesoporous polydopamine (MPDA)-based cascade-reaction nanoplatform (MPDA@AuNPs-Cu) was designed for enhanced antitumor therapy, in which ultrasmall gold nanoparticles (AuNPs) with glucose oxidase (GOx)-like activity were deposited on MPDA for providing H2O2, and Cu2+ was chelated for GSH-responsive Fenton-like reaction. It was demonstrated that the MPDA@AuNPs-Cu nanoprobe showed high photothermal conversion efficiency and excellent biocompatibility. Moreover, the MPDA@AuNPs-Cu nanoprobe exhibited strong ·OH generation because of H2O2 self-generation and photothermal stimulation. Importantly, compared with MPDA-Cu, MPDA@AuNPs-Cu exhibited enhanced in vitro and in vivo CDT/PTT performance, by which the tumor growth was completely inhibited, achieving TME-responsive antitumor efficacy.

A multimodal therapeutic nano-prodrug as an oxidative stress amplifier induces apoptosis and ferroptosis for cancer therapy

“…MPDA was synthesized through a modified method according to previous research. 42,43 Briefly, a seed solution was prepared via ultrasonically dissolving 0.9 g dopamine hydrochloride and 0.6 g F127 in the mixture of deionized water and ethanol (1 : 1). Then, 960 μL 1,3,5-trimethylbenzene (TMB) was introduced into above solution under sonication for 5 min.…”

Ultrasmall gold decorated bimetallic metal–organic framework based nanoprobes for enhanced chemodynamic therapy with triple amplification

“…The above results indicated that ultrasmall AuNPs possessed excellent self-supplying H 2 O 2 capability, which was stronger than natural GOx. 52…”

“…The above results indicated that ultrasmall AuNPs possessed excellent self-supplying H 2 O 2 capability, which was stronger than natural GOx. 52 By measuring the UV-vis absorption spectra of MB, the OH generation performance of ZIF-67@AuNPs@MnO 2 was evaluated. Firstly, by measuring the UV-vis absorption spectra of pure MB, the stability of MB was demonstrated (Fig.…”

Carbon dot-modified controllable drug delivery system for sonodynamic/chemotherapy of tumors

“…2 Currently, various combination therapies are available. According to different tumor microenvironments (TMEs), such as lower pH, 3 higher glutathione (GSH), [4][5][6] and excessive expression of folic acid receptors in cancer cells, 7,8 these characteristics have also been applied in combination therapy to achieve effects that cannot be achieved by a single treatment method. With the development of nanomedicine, multi-functional materials can be passively targeted into the tumor interior through the enhanced permeability and retention (EPR) effect so that targeted therapy can be performed at the tumor site.…”