Ultrasmall Alloy Nanozyme for Ultrasound- and Near-Infrared Light-Promoted Tumor Ablation

Abstract

The therapeutic effect of chemodynamic therapy (CDT) is significantly restricted by the stern reaction conditions and slow reaction rate of the Fenton reaction (pH 3−4). Herein, we report an ultrasmall trimetallic (Pd, Cu, and Fe) alloy nanozyme (PCF-a NEs) possessing dynamic active-site synergism, thus exhibiting a cascade glutathione peroxidase and peroxidase (POD) mimicking activities in circumneutral pH. PCF-a NEs exhibit photothermally augmented POD property and high photothermal conversion efficiency (62%) for synergistic tumor cell apoptosis. In addition, ultrasound can also enhance the mass transfer at active catalytic sites of PCF-a NEs, in turn accelerating Fenton-like reaction for tumor-specific CDT. This work provides a strategy for engineering alloy nanozymes in a bioinspired way for the amplification of intratumor reactive oxygen species in response to external stimuli, demonstrating enhanced efficiency for the inhibition of tumor growth in vitro and in vivo.

Self-amplification of oxidative stress with tumour microenvironment-activatable iron-doped nanoplatform for targeting hepatocellular carcinoma synergistic cascade therapy and diagnosis

“…Thus, therapy-resistant tumour cells are relatively more likely to be killed by ferroptosis than therapy-sensitive cancer cells [ 13 ]. Unfortunately, this approach has poor therapeutic efficacy as it is associated with relatively low iron concentrations, insufficient endogenous H 2 O 2 , and enhanced tumour antioxidant defence capability [ 14 , 15 ].…”

Ion channel-targeting near-infrared photothermal switch with synergistic effect for specific cancer therapy

“…Recently, with the aid of external stimuli, such as acoustic, optical, electric and magnetic excitations, nanomaterials have shown the potential to precisely modulate the cellular activities in a spatiotemporal manner. 11–14 Among these, optical especially near infrared (NIR) light-triggered stimulation holds great promise in cancer therapy owing to the deeper tissue penetration and lower systemic cytotoxicity. 12,13 Benefiting from the inherently temperature-sensitive property of TRPV1, nanomaterials with the ability to convert the absorbed photon energy to heat energy would be ideal nanoagonists for remote-controlled activation of TRPV1 signaling.…”

Hybrid Carbon Dot Assembly as a Reactive Oxygen Species Nanogenerator for Ultrasound-Assisted Tumor Ablation

“…Thereby, the CDT performance of CMIR-CDa was augmented in the presence of US irradiation. 40 This smart CMIR-CDa nanosystem acting as a multiple ROS ( 1 O 2 , ·OH, and O 2 • – ) generator and a fluorescence and photoacoustic tomography agent presents a commendable tumor inhibition effect in vivo ( Scheme 1 ).…”