Ultrashort Echo Time (UTE) MRI Porosity Index (PI) and Suppression Ratio (SR) Correlate with the Cortical Bone Microstructural and Mechanical Properties: Ex Vivo Study

Jerban, Saeed; Ma, Yajun; Alenezi, Salem; Moazamian, Dina; Athertya, Jiyo S.; Jang, Hyungseok; Dorthé, Erik W.; D’Lima, Darryl D.; Woods, Gina; Chung, Christine B.; Chang, Eric Y.; Du, Jiang

doi:10.2139/ssrn.4259997

Cited by 1 publication

(7 citation statements)

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“…SR is a rough estimation of the TW-to-BW ratio and demonstrated significant positive correlations with cortical bone porosity (µCT), age, 60 78 aBMD (DEXA), and vBMD (HR-pQCT) in previous investigations. 66 77 Moreover, significantly higher SR values were reported in OPo patients compared with postmenopausal normal and OPe subjects. 66 77 It should be noted that SR magnitude is sensitive to the selection of TR and TI, and an optimal combination is yet to be investigated for the highest bone evaluation performance.…”

Section: Water Content Biomarkersmentioning

confidence: 94%

“…66 77 Moreover, significantly higher SR values were reported in OPo patients compared with postmenopausal normal and OPe subjects. 66 77 It should be noted that SR magnitude is sensitive to the selection of TR and TI, and an optimal combination is yet to be investigated for the highest bone evaluation performance.…”

Section: Water Content Biomarkersmentioning

confidence: 94%

“…- SR was correlated positively with cortical bone porosity (µCT), age, 60 78 aBMD (DEXA), and vBMD (HR-pQCT) 66 77…”

Section: Water Content Biomarkersmentioning

confidence: 99%

“…The signal ratio calculation in dual-echo UTE imaging 77 78 79 is a rapid UTE-based bone evaluation technique that can be performed in a short time, like the previously mentioned TWPD, BWPD, and PWPD measures (e.g., ∼ 5 minutes, depending on the UTE acquisition techniques). This method was proposed by Rajapakse et al 79 to calculate the porosity index (PI), equal to the signal ratio between two MRI images, one with UTE (TE < 0.05 ms) and one with a TE of 2.2 ms.…”

Section: Water Content Biomarkersmentioning

confidence: 99%

“…78 79 80 Moreover, significantly higher PI was observed in OPo patients compared with OPe and subjects with normal bone. 66 77…”

Section: Water Content Biomarkersmentioning

confidence: 99%

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Bone Biomarkers Based on Magnetic Resonance Imaging

Jerban,

Jang,

Chang

et al. 2024

Semin Musculoskelet Radiol

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Magnetic resonance imaging (MRI) is increasingly used to evaluate the microstructural and compositional properties of bone. MRI-based biomarkers can characterize all major compartments of bone: organic, water, fat, and mineral components. However, with a short apparent spin-spin relaxation time (T2*), bone is invisible to conventional MRI sequences that use long echo times. To address this shortcoming, ultrashort echo time MRI sequences have been developed to provide direct imaging of bone and establish a set of MRI-based biomarkers sensitive to the structural and compositional changes of bone. This review article describes the MRI-based bone biomarkers representing total water, pore water, bound water, fat fraction, macromolecular fraction in the organic matrix, and surrogates for mineral density. MRI-based morphological bone imaging techniques are also briefly described.

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Section: Water Content Biomarkersmentioning

confidence: 94%

Section: Water Content Biomarkersmentioning

confidence: 94%

“…- SR was correlated positively with cortical bone porosity (µCT), age, 60 78 aBMD (DEXA), and vBMD (HR-pQCT) 66 77…”

Section: Water Content Biomarkersmentioning

confidence: 99%

Section: Water Content Biomarkersmentioning

confidence: 99%

“…78 79 80 Moreover, significantly higher PI was observed in OPo patients compared with OPe and subjects with normal bone. 66 77…”

Section: Water Content Biomarkersmentioning