Ultrashort echo time MRI biomarkers of asthma

Sheikh, Khadija; Guo, Fumin; Capaldi, Dante P. I.; Ouriadov, Alexei; Eddy, Rachel L.; Svenningsen, Sarah; Párraga, Grace

doi:10.1002/jmri.25503

Cited by 25 publications

(20 citation statements)

References 48 publications

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“…Recently, ultrashort echo time (UTE) MRI with 3D radial k ‐space trajectories has shown promise in overcoming these obstacles. However, experience with 3D radial UTE chest MR is limited to animal models and small human studies, mostly in adults . Moreover, 3D radial acquisitions suffer from inherent inefficiencies in fully populating k ‐space, leading to trade‐offs between longer scan times and data undersampling with lesser resolution …”

mentioning

confidence: 99%

“…However, experience with 3D radial UTE chest MR is limited to animal models and small human studies, mostly in adults. [15][16][17][18][19][20][21][22][23] Moreover, 3D radial acquisitions suffer from inherent inefficiencies in fully populating k-space, leading to trade-offs between longer scan times and data undersampling with lesser resolution. 24 UTE imaging utilizing conical k-space sampling permits greater scan efficiency than do radial acquisitions.…”

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confidence: 99%

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Free‐breathing pediatric chest MRI: Performance of self‐navigated golden‐angle ordered conical ultrashort echo time acquisition

Zucker

Cheng

Haldipur

et al. 2017

Magnetic Resonance Imaging

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confidence: 99%

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confidence: 99%

Free‐breathing pediatric chest MRI: Performance of self‐navigated golden‐angle ordered conical ultrashort echo time acquisition

Zucker

Cheng

Haldipur

et al. 2017

Magnetic Resonance Imaging

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“…Therefore, further studies are required to assess the advantage of HF-NIV when compared with gated acquisitions 2,17,23,25,27,32,33 or motionresolved reconstructions 26 at an equivalent sampling level. While the VIBE acquisition provided a valuable point of reference as a sequence frequently used in clinical practice, further comparisons with optimized breath-hold protocols [34][35][36] could be of value. Also, additional image quality improvements could be expected in UTE-HF-NIV images if retrospective gating or motion-resolved reconstructions were used to remove residual motion artifacts linked to the ventilation procedure.…”

Section: Discussionmentioning

confidence: 99%

Ultrashort echo time imaging of the lungs under high‐frequency noninvasive ventilation: A new approach to lung imaging

Delacoste

Dournes

Dunet

et al. 2019

Magnetic Resonance Imaging

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BackgroundAlthough ultrashort echo time (UTE) sequences allow excellent assessment of lung parenchyma, image quality remains lower than that of computed tomography (CT).PurposeTo investigate a high‐frequency noninvasive ventilation (HF‐NIV) technique allowing a stabilized inspiration and to compare image quality with current dedicated MR sequences.Study TypeProspective.PopulationTen healthy volunteers.Field Strength/Sequence3D radial UTE sequence at 1.5T.AssessmentUTE‐HF‐NIV sequence was compared with UTE‐free‐breathing (UTE‐FB), reconstructed at end expiration (UTE‐Exp) and average (UTE‐Avg), and breath‐hold VIBE sequences. The distance from lung apex to the dome of the right hemidiaphragm was measured. Visual assessment of the visibility and sharpness of normal anatomical structures was carried out. Dedicated software also quantitatively evaluated vessel–lung and right lung–liver interface sharpness. Apparent signal ratio (Sr) and contrast ratios (Cr) were quantitatively evaluated.Statistical TestsWilcoxon signed rank test for visual scores, paired t‐test for continuous variables, significance at P < 0.05.ResultsThe distance between apex and the right hemidiaphragmatic dome was significantly larger (P < 0.001) with UTE‐HF‐NIV compared with UTE‐FB and VIBE acquisitions. Vessel and airway visibility had identical median visual scores with all UTE methods. Median visual scores for sharpness of vessels and airways were significantly higher (P < 0.001) with HF‐NIV (vessels = 3; airways = 2) than in UTE‐FB (vessels = 2; airways = 1) and VIBE (vessels = 1; airways = 1). Software‐based vessel sharpness evaluation resulted in larger values in 8/10 volunteers with UTE‐HF‐NIV (67.3 ± 9.8) compared with UTE‐Avg (62.3 ± 12.6) but the average difference was not significant (P = 0.28). The sharpness of the lung–liver interface was significantly higher (P < 0.001) with HF‐NIV (17.3 ± 5.3) compared with UTE‐Avg (14.1 ± 3.9). Significantly higher values (P < 0.01) of Sr and Cr were observed with UTE‐HF‐NIV compared with UTE‐FB and VIBE.Data ConclusionHF‐NIV allowing acquisition at full inspiration significantly improves image quality for lung imaging. This could offer the option to alternate some follow‐up CT studies by using this technique. Level of Evidence: 2 Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2019;50:1789–1797.

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“…when using an external reference to normalize lung signal intensities. Using this approach, the normalized expiratory signal in 17 asthma patients correlates well with the CT density (r = 0.82, p = 0.004) and ventilation defect percent in hyperpolarized gas MRI (r = -0.67, p = 0.006) [50]. Furthermore, the dynamic differences between inspiration and expiration correlated well with CT density (r = 0.71, p = 0.01) as well as FEV1 % (r = 0.61, p = 0.02).…”

Section: Functional Imaging Using Ute and Potential Clinical Applicatmentioning

confidence: 94%

Outracing Lung Signal Decay – Potential of Ultrashort Echo Time MRI

Wielpütz

Triphan

Ohno

et al. 2018

Fortschr Röntgenstr

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Background Magnetic resonance imaging (MRI) of the pulmonary parenchyma is generally hampered by multiple challenges related to patient respiratory- and circulation-related motion, low proton density and extremely fast signal decay due to the structure of the lungs evolved for gas exchange. Methods Systematic literature database research as well as annual participation in conferences dedicated to pulmonary MRI for more than the past 20 years by at least one member of the author team. Results and Conclusion The problem of motion has been addressed in the past by developments such as triggering, gating and parallel imaging. The second problem has, in part, turned out to be an advantage in those diseases that lead to an increase in lung substance and thus an increase in signal relative to the background. To reduce signal decay, ultrashort echo time (UTE) methods were developed to minimize the time between excitation and readout. Having been postulated a while ago, improved hardware and software now open up the possibility of achieving echo times shorter than 200 µs, increasing lung signal significantly by forestalling signal decay and more effectively using the few protons available. Such UTE techniques may not only improve structural imaging of the lung but also enhance functional imaging, including ventilation and perfusion imaging as well as quantitative parameter mapping. Because of accelerating progress in this field of lung MRI, the review at hand seeks to introduce some technical properties as well as to summarize the growing data from applications in humans and disease, which promise that UTE MRI will play an important role in the morphological and functional assessment of the lung in the near future. Key Points: Citation Format

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Ultrashort echo time MRI biomarkers of asthma

Abstract: 2 J. Magn. Reson. Imaging 2017;45:1204-1215.

Cited by 25 publications

References 48 publications

Free‐breathing pediatric chest MRI: Performance of self‐navigated golden‐angle ordered conical ultrashort echo time acquisition

Free‐breathing pediatric chest MRI: Performance of self‐navigated golden‐angle ordered conical ultrashort echo time acquisition

Ultrashort echo time imaging of the lungs under high‐frequency noninvasive ventilation: A new approach to lung imaging

Outracing Lung Signal Decay – Potential of Ultrashort Echo Time MRI

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