Ultrasensitive TLC determination of montlukast and loratadine mixture in human plasma utilizing fluorescence detection at dual pH values: Toward attaining separate maximum fluorescence intensity

Khorshed, Ahmed A.; Abdelnaeem, Fatma M.; Derayea, Sayed M.; Nagy, Dalia M.; Oraby, Mohamed

doi:10.1016/j.jchromb.2022.123161

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…where SD and S are standard deviation and slope, respectively. 30 The recovery (%) was also calculated using eqn (4) to detect the accuracy of the current sensor in real samples. 31,32 Recovery ð%Þ ¼ ðclinical conc: providedÞ ðfound conc:Þ Â 100 (4)…”

Section: Detection Of Acrylamide and Acetone Using G-ag Nps Luminesce...mentioning

confidence: 99%

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Fluorescent garlic-capped Ag nanoparticles as dual sensors for the detection of acetone and acrylamide

et al. 2022

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Section: Detection Of Acrylamide and Acetone Using G-ag Nps Luminesce...mentioning

confidence: 99%

“…The limit of detection (LOD) of acrylamide or acetone was determined using eqn (3).where SD and S are standard deviation and slope, respectively. 30…”

Section: Experimental Workmentioning

confidence: 99%

Fluorescent garlic-capped Ag nanoparticles as dual sensors for the detection of acetone and acrylamide

et al. 2022

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“…The available literature review revealed various methods for analyzing MTK. These methods were spectrophotometric [ 8 , 9 ], spectrofluorimetric [ 10 , 11 ], HPTLC [ 7 , 12 , 13 ], HPLC [ 14 , 15 ] and electrochemical methods [ 16 , 17 ]. BIL is a second-generation antihistaminic medication that is administered orally to treat allergic rhinitis symptoms [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a green synchronous spectrofluorimetric technique for simultaneous determination of Montelukast sodium and Bilastine in pharmaceutical formulations

Derayea,

Badr El-Din,

Ahmed

et al. 2024

BMC Chemistry

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For the treatment of rhinitis and asthma, a combination of Montelukast sodium and Bilastine has just been approved. Based on the first derivative of synchronous fluorescence, the current work developed a green, highly accurate, sensitive, and selective spectroscopic approach for estimating Montelukast sodium and Bilastine in pharmaceutical dosage form without previous separation. The selected technique focuses on measuring the synchronized fluorescence of the studied medications at a fixed wavelength range (Δλ) = 110 nm, and using the amplitude of the first derivative's peak at 381 and 324 nm, for quantitative estimation of Montelukast sodium and Bilastine, respectively. The impacts of different factors on the referred drugs' synchronized fluorescence intensity were investigated and adjusted. The calibration plots for were found to be linear over concentration ranges of 50–2000 ng mL−1 for Montelukast sodium and 50–1000 ng mL−1 for Bilastine. Montelukast sodium and Bilastine have LODs of 16.5 and 10.9 ng mL−1, respectively. In addition, LOQs were: 49.9 and 33.0 ng mL−1, for both drugs, respectively. The developed method was successfully employed to quantify the two drugs in synthetic tablets mixture and in laboratory prepared mixtures containing varied Montelukast and Bilastine ratios. To compare the results with the published analytical approach, a variance ratio F-test and a student t-test were used, which revealed no significant differences.

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Concurrent estimation of montelukast and loratadine mixture in spiked human plasma utilizing high-performance thin-layer chromatography with ultraviolet detection

Khorshed

Abdelnaeem

Derayea

et al. 2022

JPC-J Planar Chromat

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Ultrasensitive TLC determination of montlukast and loratadine mixture in human plasma utilizing fluorescence detection at dual pH values: Toward attaining separate maximum fluorescence intensity

Cited by 7 publications

References 33 publications

Fluorescent garlic-capped Ag nanoparticles as dual sensors for the detection of acetone and acrylamide

Fluorescent garlic-capped Ag nanoparticles as dual sensors for the detection of acetone and acrylamide

Development of a green synchronous spectrofluorimetric technique for simultaneous determination of Montelukast sodium and Bilastine in pharmaceutical formulations

Concurrent estimation of montelukast and loratadine mixture in spiked human plasma utilizing high-performance thin-layer chromatography with ultraviolet detection

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