Ultrasensitive supersandwich-type electrochemical sensor for SARS-CoV-2 from the infected COVID-19 patients using a smartphone

Abstract

Graphical abstract

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

“…Once commercialized, these portable ECBs could be highly effective in contact tracing and controlling the spread of 2019-nCoV. [296]. Reprinted with permission from [296], Copyright © 2020 published by Elsevier B.V.…”

COVID-19: A challenge for electrochemical biosensors

“…A complex nanotechnological approach to the SARS-CoV-2 genome using a supersandwich-type biosensor was developed by Zhao et al. [ 82 ]. First, they selectively isolated clinical RNA samples using magnetic particles modified with thiolated capture DNA probe (CP) via affinity of thiols to gold.…”

Trends in biosensing platforms for SARS-CoV-2 detection: A critical appraisal against standard detection tools

“…(A) Electrochemical biosensing podiums to detect different viruses including SARS-CoV-2 , Reprinted with permission [ 95 ] (B) Scheme representing the concept of SPCE/NPs/nano-Dendroids/GO/Ab probe fabrication to diagnose COVID-19, Reprinted with permission [ 100 ], Schematic illustration of (C) Preparation of premix (D) Use of smartphone in SARS-CoV-2 detection using the electrochemical biosensing platform. Reprinted with permission [ 104 ]. …”

“…Magnetic beads based sensor offers the possibility of loading enhanced amount to capture antibody because of high surface area. More recently, Li’s research group has introduced an electrochemical sensing platform using smartphone for the detection of SARS-CoV-2 from infected patients as shown in Figure 4 C and D [ 104 ]. Using supersandwich-type recognition approach, electrochemical smartphone was able to detect RNA of SARS-CoV-2 without nucleic acid amplification and reverse-transcription.…”