Ultrasensitive, Selective, and Highly Stable Bioelectronic Nose That Detects the Liquid and Gaseous Cadaverine

Oh, Jungkyun; Yang, Heehong; Jeong, Go Een; Moon, Dongseok; Kwon, Oh Seok; Phyo, Sooyeol; Lee, Jiwon; Song, Hyun Seok; Park, Tai Hyun; Jang, Jyongsik

doi:10.1021/acs.analchem.9b01068

Cited by 44 publications

(41 citation statements)

References 40 publications

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“…In this method, the receptor and lipid bilayer are wrapped with membrane scaffold proteins (MSPs). The stability of NDs embedded with GPCRs and the superiority in detection by the sensor is reported (Oh et al 2019). However, studies describing the reconstitutions of CRHR1 and MC2R using NDs or the application of the CRHR1ND and MC2RND in the sensor have not been carried out before.…”

Section: Construction Of the Bioelectronic Sensor Systemmentioning

confidence: 99%

Bioelectronic sensor mimicking the human neuroendocrine system for the detection of hypothalamic-pituitary-adrenal axis hormones in human blood

Lee

Yang

et al. 2020

Biosensors and Bioelectronics

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In the neuroendocrine system, corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) play important roles in the regulation of the hypothalamic-pituitary-adrenal (HPA) system. Disorders of the HPA system lead to physiological problems, such as Addison's disease and Cushing's syndrome. Therefore, detection of CRH and ACTH is essential for diagnosing disorders related to the HPA system. Herein, receptors of the HPA axis were used to construct a bioelectronic sensor system for the detection of CRH and ACTH. The CRH receptor, corticotropin-releasing hormone receptor 1 (CRHR1), and the ACTH receptor, melanocortin 2 receptor (MC2R), were produced using an Escherichia coli expression system, and were reconstituted using nanodisc (ND) technology. The receptor-embedded NDs were immobilized on a floating electrode of a carbon nanotube field-effect transistor (CNT-FET).The constructed sensors sensitively detected CRH and ACTH to a concentration of 1 fM with high selectivity in real time. Furthermore, the reliable detection of CRH and ACTH in human plasma by the developed sensors demonstrated their potential in clinical and practical applications. These results indicate that CRHR1 and MC2R-based bioelectronic sensors can be applied for rapid and efficient detection of CRH and ACTH.

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Section: Construction Of the Bioelectronic Sensor Systemmentioning

confidence: 99%

Bioelectronic sensor mimicking the human neuroendocrine system for the detection of hypothalamic-pituitary-adrenal axis hormones in human blood

Lee

Yang

et al. 2020

Biosensors and Bioelectronics

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“…Proteins interacting with volatile organic compounds (VOCs) in the human nose (a) and examples of olfactory sensors designed from biosourced materials (b). Trace amine associated receptors (TAAR) in lipidic nanodiscs grafted on a field-effect transistor for the detection of cadaverine (adapted from [15]). (c) Three different kind of odorant binding proteins (OBPs) deposited on surface acoustic wave sensors for carvone sensing (adapted from [16]).…”

Section: Bio-sourced Materialsmentioning

confidence: 99%

“…First, their structure is essential for their binding function, and a lipidic environment is necessary to preserve it. Membrane fractions [20,21], then nanovesicles or nanoliposomes [22][23][24][25], and eventually nanodiscs ( Figure 2b) [15,26,27] have been used to achieve their immobilization on sensors. Second, the fact that they are not soluble makes their production challenging.…”

Section: Bio-sourced Materialsmentioning

confidence: 99%

Bio-Inspired Strategies for Improving the Selectivity and Sensitivity of Artificial Noses: A Review

Hurot

Scaramozzino

Buhot

et al. 2020

Sensors

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Artificial noses are broad-spectrum multisensors dedicated to the detection of volatile organic compounds (VOCs). Despite great recent progress, they still suffer from a lack of sensitivity and selectivity. We will review, in a systemic way, the biomimetic strategies for improving these performance criteria, including the design of sensing materials, their immobilization on the sensing surface, the sampling of VOCs, the choice of a transduction method, and the data processing. This reflection could help address new applications in domains where high-performance artificial noses are required such as public security and safety, environment, industry, or healthcare.

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“…No high repeat accuracy can be guaranteed yet. 0 [32,35,36] High selectivity It can be tested very specifically for certain substances. As illustrated in Figure 2, biosensors have advantages in terms of sensitivity, selectivity, specificity, accuracy, and resolution.…”

Section: Fulfillment Rating Referencesmentioning

confidence: 99%

Market Perspectives and Future Fields of Application of Odor Detection Biosensors—A Systematic Analysis

Full

Delbrück

Sauer

et al. 2020

The 1st International Electronic Conference on Biosensors

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The technological advantages that biosensors have over conventional technical sensors for odor detection have not yet been comprehensively analyzed. However, this is necessary for assessing their suitability for specific fields of application as well as their improvement and development goals. In this paper specific market potentials of biosensors for odor detection are identified by applying a tailored methodology that enables the derivation and systematic comparison of both the performance profiles of biosensors as well as the requirement profiles for various application fields. Therefore, the fulfillment of defined requirements is evaluated for biosensors by means of 16 selected technical criteria in order to determine a specific performance profile. Further, a selection of application fields for odor detection sensors is derived to compare the importance of the criteria for each of the fields, leading to market-specific requirement profiles. The analysis reveals that the requirement criteria considered to be the most important ones across all application fields are high specificity, high selectivity, high repeat accuracy, high resolution, high accuracy, and high sensitivity. All these criteria, except for the repeat accuracy, can potentially be better met by biosensors than by technical sensors, according to the results obtained. Therefore, biosensor technology in general has a high application potential for all the areas of application under consideration. Health and safety applications especially are considered to have high potential for biosensors due to their correspondence between requirement and performance profiles.

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Ultrasensitive, Selective, and Highly Stable Bioelectronic Nose That Detects the Liquid and Gaseous Cadaverine

Cited by 44 publications

References 40 publications

Bioelectronic sensor mimicking the human neuroendocrine system for the detection of hypothalamic-pituitary-adrenal axis hormones in human blood

Bioelectronic sensor mimicking the human neuroendocrine system for the detection of hypothalamic-pituitary-adrenal axis hormones in human blood

Bio-Inspired Strategies for Improving the Selectivity and Sensitivity of Artificial Noses: A Review

Market Perspectives and Future Fields of Application of Odor Detection Biosensors—A Systematic Analysis

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