Ultrasensitive SEIRA detection using gold nanobipyramids: Toward efficient multimodal immunosensor

Towards multi-molecular surface-enhanced infrared absorption using metal plasmonics

“…Along similar lines, the lower limit of detection of the streptavidin–biotin interaction was 10 −10 M, measured on Au–Ag semi-nanoshells, 88 and 10 −12 M on colloidal gold nanobipyramids. 89 Giessen, Neubrech and colleagues studied the reversible transformation between α-helix and β-sheet for poly- l -lysine, using rod-shaped nanoantennas to enhance the amide I band. 83 By coupling the poly- l -lysine monolayer to the plasmonic rod-antennas, the reversibility of the changes was demonstrated in vitro .…”

Innovative, Flexible, and Miniaturized Microfluidic Paper-Based Plasmonic Chip for Efficient Near-Infrared Metal Enhanced Fluorescence Biosensing and Imaging

“…22 Apart from the controlled synthesis process, which allows the manipulation of their LSPR over a broad region of the electromagnetic spectrum from the visible to the near-infrared (NIR), AuBPs present a strongly amplified electromagnetic field at their sharp tips, thus being successfully exploited in sensing applications of ultralow target analyte concentrations using plasmon-enhanced detection methods. 23,24 These features make them excellent candidates for metal-enhanced fluorescence (MEF) applications. MEF relies on the amplification of the fluorescence emission of fluorophores when they are placed in the electromagnetic field of the nanoparticles at a specific distance (5 to 20 nm) 25 from the metallic surface, thus overcoming the limitations of fluorescence-based sensing and imaging such as poor sensitivity.…”

Single Gold Nanobipyramids Sensing the Chirality of Amyloids

“…16,17 Moreover, gold bipyramids are an interesting material from a single-molecule sensing perspective since they are more homogeneous in aspect ratio and plasmon wavelength than other broadly used anisotropic nanoparticles. 18 Such properties are beneficial for bioimaging 19 and biosensing 20 noninvasive way and target specific analytes due to enantioselective interactions.…”

“…These include gold nanobipyramids (BPs) characterized by complex anisotropic geometry and sharp tips which are proven to enhance electric field more efficiently than broadly studied nanorods, thus making them more suitable for chirality detection. , Moreover, gold bipyramids are an interesting material from a single-molecule sensing perspective since they are more homogeneous in aspect ratio and plasmon wavelength than other broadly used anisotropic nanoparticles . Such properties are beneficial for bioimaging and biosensing in the so-called biological optical window, allowing us to monitor biological processes in situ in a noninvasive way and target specific analytes due to enantioselective interactions.…”