Ultrasensitive reporter DNA sensors built on nucleic acid amplification techniques: Application in the detection of trace amount of protein

Du, Jungang; He, Jin-song; Wang, Rui; Wu, Jian; Yu, Xiaoping

doi:10.1016/j.bios.2023.115761

Biosensors and Bioelectronics

2024

DOI: 10.1016/j.bios.2023.115761

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Ultrasensitive reporter DNA sensors built on nucleic acid amplification techniques: Application in the detection of trace amount of protein

Jungang Du,

Jin-song He,

Rui Wang

et al.

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Recent Progress in DNA Biosensors for Detecting Biomarkers in Living Cells

Dong,

Su,

et al. 2024

ACS Biomater. Sci. Eng.

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Analysis of biomarkers in living cells is crucial for deciphering the dynamics of cells as well as for precise diagnosis of diseases. DNA biosensors employ DNA sequences as probes to offer insights into living cells, and drive progress in disease diagnosis and drug development. In this review, we present recent advances in DNA biosensors for detecting biomarkers in living cells. The basic structural components of DNA biosensors and the signal output method are presented. The strategies of DNA biosensors crossing the cell membrane are also described, including coincubation, nanocarriers, and nanoelectroporation techniques. Based on biomarker categorization, we detail recent applications of DNA biosensors for detecting small molecules, RNAs, proteins, and integrated targets in living cells. Furthermore, the future development directions of DNA biosensors are summarized to encourage further research in this growing field.

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Recent Progress in DNA Biosensors for Detecting Biomarkers in Living Cells

Dong,

Su,

et al. 2024

ACS Biomater. Sci. Eng.

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Ultrasensitive reporter DNA sensors built on nucleic acid amplification techniques: Application in the detection of trace amount of protein

Cited by 1 publication

References 101 publications

Recent Progress in DNA Biosensors for Detecting Biomarkers in Living Cells

Recent Progress in DNA Biosensors for Detecting Biomarkers in Living Cells

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