Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent

Kawano, Takahito; Murata, Masaru; Kang, Jeong Hun; Piao, Jing Shu; Narahara, Sayoko; Hyodo, Fuminori; Hamano, Nobuhito; Guo, Jie; Oguri, Susumu; Ohuchida, Kenoki; Hashizume, Makoto

doi:10.1016/j.biomaterials.2017.10.029

Cited by 29 publications

(31 citation statements)

References 35 publications

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“…These were further functionalised with maleimide-DTPA-Gd 3+ using a cysteine residue of the protein with the relaxometric properties analysed for four nanocages with different sizes (from 16.8 to 37.1 nm). The data revealed that higher r 1 values (up to 47 mM −1 ·s −1 at 1.5 T) were obtained in larger nanocages due to the reduction in the tumbling rate of associated water molecules [44].…”

Section: Paramagnetic Nanoparticlesmentioning

confidence: 99%

Nanoparticle-Based Paramagnetic Contrast Agents for Magnetic Resonance Imaging

Pellico

Ellis

Davis

2019

Contrast Media & Molecular Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging modality that is routinely used in clinics, providing anatomical information with micron resolution, soft tissue contrast, and deep penetration. Exogenous contrast agents increase image contrast by shortening longitudinal (T1) and transversal (T2) relaxation times. Most of the T1 agents used in clinical MRI are based on paramagnetic lanthanide complexes (largely Gd-based). In moving to translatable formats of reduced toxicity, greater chemical stability, longer circulation times, higher contrast, more controlled functionalisation and additional imaging modalities, considerable effort has been applied to the development of nanoparticles bearing paramagnetic ions. This review summarises the most relevant examples in the synthesis and biomedical applications of paramagnetic nanoparticles as contrast agents for MRI and multimodal imaging. It includes the most recent developments in the field of production of agents with high relaxivities, which are key for effective contrast enhancement, exemplified through clinically relevant examples.

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Section: Paramagnetic Nanoparticlesmentioning

confidence: 99%

Nanoparticle-Based Paramagnetic Contrast Agents for Magnetic Resonance Imaging

Pellico

Ellis

Davis

2019

Contrast Media & Molecular Imaging

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“…143 In the context of pancreatic cancer imaging, a wide range of biomarkers have been imaged through peptides as targeting ligands. Those targets are proteins mainly located on plasma membrane such as neuropilin-1, 89 EGFR, 116,127 uPAR, 96 and integrin αvβ6, 47,48,104,112,121 and several others have tested theranostic application of peptides in various models. 48,90,112,116 Moreover, the peptide transporter 1 (PEPT1) is also investigated as another relevant biomarker of pancreatic cancer.…”

Section: Molecularly Targeted Ucas In Pdac Imagingmentioning

confidence: 99%

Current status of targeted microbubbles in diagnostic molecular imaging of pancreatic cancer

Jugniot

Bam

Meuillet

et al. 2020

Bioengineering & Transla Med

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Pancreatic ductal adenocarcinoma (PDAC) is often associated with a poor prognosis due to silent onset, resistance to therapies, and rapid spreading. Most patients are ineligible for curable surgery as they present with advanced disease at the time of diagnosis. Present diagnostic methods relying on anatomical changes have various limitations including difficulty to discriminate between benign and malignant conditions, invasiveness, the ambiguity of imaging results, or the inability to detect molecular biomarkers of PDAC initiation and progression. Therefore, new imaging technologies with high sensitivity and specificity are critically needed for accurately detecting PDAC and noninvasively characterizing molecular features driving its pathogenesis. Contrast enhanced targeted ultrasound (CETUS) is an upcoming molecular imaging modality that specifically addresses these issues. Unlike anatomical imaging modalities such as CT and MRI, molecular imaging using CETUS is promising for early and accurate detection of PDAC. The use of molecularly targeted microbubbles that bind to neovascular targets can enhance the ultrasound signal specifically from malignant PDAC tissues. This review discusses the current state of diagnostic imaging modalities for pancreatic cancer and places a special focus on ultrasound targetedmicrobubble technology together with its clinical translatability for PDAC detection.

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“…Thus, these sHsp cages may provide efficient imaging agent carriers to monitor the therapeutic evaluation by imaging caspase activity within tumors. Similarly, Hsp16.5-based nanocages, conjugated with gadolinium (III)-chelated agents and iRGD peptides, were developed for the diagnosis of pancreatic cancers by magnetic resonance imaging (MRI) [170]. It showed that sHsps have great potential in the diagnosis of cancers as a carrier to construct a specific and sensitive MRI contrast agent.…”

Section: Shsps-based Cancer Therapymentioning

confidence: 99%

Small Heat Shock Proteins in Cancers: Functions and Therapeutic Potential for Cancer Therapy

Xiong

Tan

et al. 2020

IJMS

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Small heat shock proteins (sHSPs) are ubiquitous ATP-independent chaperones that play essential roles in response to cellular stresses and protein homeostasis. Investigations of sHSPs reveal that sHSPs are ubiquitously expressed in numerous types of tumors, and their expression is closely associated with cancer progression. sHSPs have been suggested to control a diverse range of cancer functions, including tumorigenesis, cell growth, apoptosis, metastasis, and chemoresistance, as well as regulation of cancer stem cell properties. Recent advances in the field indicate that some sHSPs have been validated as a powerful target in cancer therapy. In this review, we present and highlight current understanding, recent progress, and future challenges of sHSPs in cancer development and therapy.

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Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent

Cited by 29 publications

References 35 publications

Nanoparticle-Based Paramagnetic Contrast Agents for Magnetic Resonance Imaging

Nanoparticle-Based Paramagnetic Contrast Agents for Magnetic Resonance Imaging

Current status of targeted microbubbles in diagnostic molecular imaging of pancreatic cancer

Small Heat Shock Proteins in Cancers: Functions and Therapeutic Potential for Cancer Therapy

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