Ultrasensitive Molecular Detection by Imaging of Centimeter‐Scale Metasurfaces with a Deterministic Gradient Geometry

Min, Siyi; Li, Shijie; Zhu, Zhouyang; Liu, Yu; Liang, Chao; Han, Fei; Li, Yuyan; Cai, Wenshan; Cheng, Xing; Li, Wen‐Di

doi:10.1002/adma.202100270

Cited by 16 publications

(22 citation statements)

References 36 publications

(17 reference statements)

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“…The holographic grating and disposable metasurface are fabricated through solution‐processed approaches modified from our previous publications. [ 14 , 25 , 30 , 31 ] Typically, the holographic grating is nanotransferred onto a spherical lens using polyvinyl alcohol (PVA) as the intermediate carrier. The nanotransfer process of the metallic grating is shown in Figure 2 .…”

Section: Resultsmentioning

confidence: 99%

“…where Δp max is the maximum (saturation) value of pixel shift Δp, K is the associated equilibrium constant, and c is the concentration of the human IgG solution. Figure 6e presents the fitting of the measured maxima position and the IgG solution concen- Funari et al [33] N/A ≈0.08 ng mL −1 183 nm/RIU Spectrometer Lu et al [34] N/A 1.1 nm 326 nm/RIU Spectrometer Cetin et al [28] ≈4 × 10 −3 RIU N/A 621 nm/RIU Spectrometer Wang et al [35] N/A 60.7 pm 284 nm/RIU Spectrometer Hao et al [36] N/A 1.88 μg mL −1 273 nm/RIU Spectrometer Fernández et al [37] N/A ≈5.98 nm 587 nm/RIU Spectrometer Cao et al [38] N/A ≈0.4 nm 801 nm/RIU Spectrometer Xu et al [39] 9.54 × 10 −8 RIU >12.6 pm N/A Spectrometer Seiler et al [40] ≈5 × 10 −4 RIU N/A 175 pixel/RIU Image Coskun et al [41] 2 × 10 −3 RIU N/A 17.5392/RIU Image Cetin et al [42] N/A 0.4 ng mL −1 430 nm/RIU Image Min et al [25] 9.6 × 10 tration using the Langmuir model, from which the equilibrium constant K can be calculated to be 6.25 × 10 10 m −1 , implying a good agreement with previous reports. [32] The inset in Figure 6e presents a linear fit of the position of intensity maxima for IgG concentrations on a linear scale (0.2 to 1.0 ng mL −1 ).…”

Section: Resultsmentioning

confidence: 99%

“…One of the most promising techniques is space‐multiplexed molecule detection based on metasurfaces with properly designed spatially varying nanostructures. [ 24 , 25 , 26 , 27 ] Because of the structure‐dependent scattering properties, the metasurface has structure‐dependent reflectance or transmittance under narrowband illuminations, which induces an intensity pattern. Therefore, attached analyte molecules on the metasurface alter the intensity pattern, which can be recorded by a camera and used to detect the existence of target molecules.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasensitive Molecular Detection at Subpicomolar Concentrations by the Diffraction Pattern Imaging with Plasmonic Metasurfaces and Convex Holographic Gratings

et al. 2022

Advanced Science

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Compact and cost‐effective optical devices for highly sensitive detection of trace molecules are significant in many applications, including healthcare, pollutant monitoring and explosive detection. Nanophotonic metasurface‐based sensors have been intensively attracting attentions for molecular detection. However, conventional methods often involve spectroscopic characterizations that require bulky, expensive and sophisticated spectrometers. Here, a novel ultrasensitive sensor of plasmonic metasurfaces is designed and fabricated for the detection of trace molecules. The sensor features a convex holographic grating, of which the first‐order diffraction pattern of a disposable metasurface is recorded by a monochrome camera.The diffraction pattern changes with the molecules attached to the metasurface, realizing label‐free and spectrometer‐free molecular detection by imaging and analyzing of the diffraction pattern. By integrating the sensor with a microfluidic setup, the quantitative characterization of rabbit anti‐human Immunoglobulin G (IgG) and human IgG biomolecular interactions is demonstrated with an excellent limit of detection (LOD) of 0.6 p m . Moreover, both the metasurface and holographic grating are obtained through vacuum‐free solution‐processed fabrications, minimizing the manufacturing cost of the sensor. A prototype of the imaging‐based sensor, consisting of a white light‐emitting diode (LED) and a consumer‐level imaging sensor is achieved to demonstrate the potential for on‐site detection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ultrasensitive Molecular Detection at Subpicomolar Concentrations by the Diffraction Pattern Imaging with Plasmonic Metasurfaces and Convex Holographic Gratings

et al. 2022

Advanced Science

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“…Min et al. [ 176 ] presented a centimeter (cm) scale plasmonic metasurface with regular but appropriately adjusted holes and pillars for ultrasensitive, spectrometer‐free, and label‐free detection of a single‐layer of the molecules adsorbed on a surface.…”

Section: Applications Of Metasurfaces For Molecular Optical Sensingmentioning

confidence: 99%

Section: Applications Of Metasurfaces For Molecular Optical Sensingmentioning

confidence: 99%

Optical Sensing by Metamaterials and Metasurfaces: From Physics to Biomolecule Detection

Khan

Xie

et al. 2022

Advanced Optical Materials

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Optical biosensors are a versatile detection and analysis tool used in biological research, health care, pharmaceuticals, environmental monitoring, homeland security, and the battlefield. [1] They do not interfere with electromagnetic (EM) radiation, manifest distant sensing capability, and may enable multiplexed detection in a single device. Optical biosensing technologies are widely used in current biomedical and environmental monitoring applications because they provide a reliable and quick way to identify and discriminate specific objects from a wide range of samples. [2][3][4][5] More interestingly, Optical biosensors outperform standard analytical techniques by delivering highly-sensitive, selective, and cost-effective real-time and label-free detection of biological and chemical molecules. [6,7] High specificities, sensitivity, small size, and cost-effectiveness are among the benefits.Metasurfaces are planar or 2D forms of metamaterials made up of arrays of antennas with a subwavelength thickness. They have been rapidly developed in the recent years due to their ability to manipulate light-matter interaction in both linear and non-linear regimes at the nanoscale. Various metasurfaces display remarkable optical features, such as acute resonance, significant nearfield enhancement, and suitable capacity to support electric and magnetic modes, on account of the strong light-matter interaction and the low optical loss. Due to these important properties, they can be used in several advanced optoelectronic applications, like surface-enhanced spectroscopy, photocatalysis, and sensing. This review reports on the recent progress of metamaterials and metasurfaces in molecular optical sensors. The principles that govern plasmonic and dielectric metasurfaces along with their features are outlined, supported by numerous examples. Then, the factors that result in a high Q-factor are presented in order to show that metamaterials and metasurfaces can be used for label-free sensing in a variety of detection mechanisms, including surface-enhanced spectroscopy, refractometric sensing, and surface-enhanced thermal emission spectroscopy via infrared absorption and Raman scattering, as well as chiral sensing. Finally, the challenges for future development are outlined.

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Hybrid Metasurfaces of Plasmonic Lattices and 2D Materials

Guo

Deng

2023

Adv Funct Materials

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Plasmonic metasurfaces can significantly enhance the interaction between light and 2D materials. Hybrid structures of plasmonic lattices and 2D materials show great promise for both fundamental and practical studies because of their unprecedented ability for precise manipulation of light at the nanoscale. This review starts with an overview of the basic concepts of plasmonic lattices and optical properties of 2D materials, as well as fabrication strategies for hybrid metasurfaces. Then, the enhanced photoluminescence, quantum emission, optoelectronic detection, nonlinear process, and valleytronics in hybrid metasurfaces are summarized, and their development for nanophotonic functional devices are reviewed. Further, several compelling topics are also outlined that provide outlooks for future directions of hybrid metasurfaces such as novel structural design and high‐quality fabrication, all‐dielectric metasurfaces, dynamic metasurfaces, and plasmonic mediation of chemical reactions and physical processes. It is believed that hybrid metasurfaces of plasmonic lattices and 2D materials can open prospects for versatile platforms for light‐matter interactions and contribute to the revolutions on nanophotonic devices.

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Ultrasensitive Molecular Detection by Imaging of Centimeter‐Scale Metasurfaces with a Deterministic Gradient Geometry

Abstract: Metasurfaces with metallic [1] and dielectric [2] nanophotonic building blocks manipulate light scattering in the subwavelength

Cited by 16 publications

References 36 publications

Ultrasensitive Molecular Detection at Subpicomolar Concentrations by the Diffraction Pattern Imaging with Plasmonic Metasurfaces and Convex Holographic Gratings

Ultrasensitive Molecular Detection at Subpicomolar Concentrations by the Diffraction Pattern Imaging with Plasmonic Metasurfaces and Convex Holographic Gratings

Optical Sensing by Metamaterials and Metasurfaces: From Physics to Biomolecule Detection

Hybrid Metasurfaces of Plasmonic Lattices and 2D Materials

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