Ultrasensitive detection of hazardous reactive oxygen species using flexible organic transistors with polyphenol-embedded conjugated polymer sensing layers

Jeong, Jaehoon; Essafi, Makram; Lee, Chulyeon; Haoues, Meriam; Diouani, Mohamed Fethi; Kim, Hwajeong; Kim, Youngkyoo

doi:10.1016/j.jhazmat.2018.04.063

Cited by 22 publications

(15 citation statements)

References 49 publications

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“…Although the free radical has a strong doping effect to graphene 33,34 , it is still challenging to directly monitor the free radical in the aqueous environment by the FET sensors. One pioneering work 35 develops a poly(3-hexylthiophene) FET sensor functionalized with rutin. The oxidation of rutin by superoxide (•O 2 − ) induces current perturbations and enables the detection of •O 2 − .…”

Section: Introductionmentioning

confidence: 99%

Free radical sensors based on inner-cutting graphene field-effect transistors

Wang

Lin

et al. 2019

Nat Commun

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Due to ultra-high reactivity, direct determination of free radicals, especially hydroxyl radical (•OH) with ultra-short lifetime, by field-effect transistor (FET) sensors remains a challenge, which hampers evaluating the role that free radical plays in physiological and pathological processes. Here, we develop a •OH FET sensor with a graphene channel functionalized by metal ion indicators. At the electrolyte/graphene interface, highly reactive •OH cuts the cysteamine to release the metal ions, resulting in surface charge de-doping and a current response. By this inner-cutting strategy, the •OH is selectively detected with a concentration down to 10 −9 M. Quantitative metal ion doping enables modulation of the device sensitivity and a quasi-quantitative detection of •OH generated in aqueous solution or from living cells. Owing to its high sensitivity, selectivity, real-time label-free response, capability for quasi-quantitative detection and user-friendly portable feature, it is valuable in biological research, human health, environmental monitoring, etc.

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Section: Introductionmentioning

confidence: 99%

Free radical sensors based on inner-cutting graphene field-effect transistors

Wang

Lin

et al. 2019

Nat Commun

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“…This value indicates much lower toxicity of SSA than that of PAHs, such benzo[k]fluoranthene (LD 50 = 14 μg/kg) or other PAHs with an LD 50 below 90 μg/kg [ 31 ]. Even in recent studies, a high cytotoxicity of polyphenolic compounds has been revealed [ 32 ], while polyphenols are specifically used for organic semiconductors applied in flexible electronics [ 33 ]. On the other hand, the precursor of SSA is salicylic acid—a veritable green compound that acts as a plant hormone or vascular drug [ 22 ].…”

Section: Discussion About the N-type Characteristics And The Low mentioning

confidence: 99%

Sulpho-Salicylic Acid Grafted to Ferrite Nanoparticles for n-Type Organic Semiconductors

et al. 2020

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A disadvantage of the use of pentacene and typical organic materials in electronics is that their precursors are toxic for manufacturers and the environment. To the best of our knowledge, this is the first report of an n-type non-toxic semiconductor for organic transistors that uses sulpho-salicylic acid—a stable, electron-donating compound with reduced toxicity—grafted on a ferrite core–shell and a green synthesis method. The micro-physical characterization indicated a good dispersion stability and homogeneity of the obtained nanofilms using the dip-coating technique. The in-situ electrical characterization was based on a point-contact transistor configuration, and the increase in the drain current as the positive gate voltage increased proved the functionality of the n-type semiconductor.

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“…Electrochemical techniques employ the same principle as the fluorescence method as they combine electrochemical reactions with specific sensing elements to selectively detect O •− 2 . Several publications between 2016 to 2020 showed the detection of O •− 2 in cancerous cells [89,90], tumorous cells [91,92], macrophages [93,94], skeletal muscle cells, human glioblastoma cells, and human keratinocyte cells [47]. However, there are still several limitations that need to be considered when implementing electrochemical techniques for O •− 2 detection, especially in tissues.…”

Section: Electrochemical Methods For Superoxide Radical (O •−mentioning

confidence: 99%

Detection Technologies for Reactive Oxygen Species: Fluorescence and Electrochemical Methods and Their Applications

et al. 2021

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Reactive oxygen species (ROS) have been found in plants, mammals, and natural environmental processes. The presence of ROS in mammals has been linked to the development of severe diseases, such as diabetes, cancer, tumors, and several neurodegenerative conditions. The most common ROS involved in human health are superoxide (O2•−), hydrogen peroxide (H2O2), and hydroxyl radicals (•OH). Organic and inorganic molecules have been integrated with various methods to detect and monitor ROS for understanding the effect of their presence and concentration on diseases caused by oxidative stress. Among several techniques, fluorescence and electrochemical methods have been recently developed and employed for the detection of ROS. This literature review intends to critically discuss the development of these techniques to date, as well as their application for in vitro and in vivo ROS detection regarding free-radical-related diseases. Moreover, important insights into and further steps for using fluorescence and electrochemical methods in the detection of ROS are presented.

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Ultrasensitive detection of hazardous reactive oxygen species using flexible organic transistors with polyphenol-embedded conjugated polymer sensing layers

Cited by 22 publications

References 49 publications

Free radical sensors based on inner-cutting graphene field-effect transistors

Free radical sensors based on inner-cutting graphene field-effect transistors

Sulpho-Salicylic Acid Grafted to Ferrite Nanoparticles for n-Type Organic Semiconductors

Detection Technologies for Reactive Oxygen Species: Fluorescence and Electrochemical Methods and Their Applications

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