Ultrasensitive detection of dopamine using a polysilicon nanowire field-effect transistor

Lin, Chih Heng; Hsiao, Cheng Yun; Hung, Cheng Hsiung; Lo, Yen Ren; Lee, Cheng Che; Su, Chun Jung; Lin, Horng–Chih; Ko, Fu‐Hsiang; Huang, Tiao‐Yuan; Yang, Yuh‐Shyong

doi:10.1039/b812968a

Cited by 71 publications

(34 citation statements)

References 32 publications

(42 reference statements)

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“…Recently, the dopamine detection by using ion-sensitive FET devices modified with phenylboronic acid has been reported (Freeman et al, 2007). An ultrasensitive dopamine FET sensor based on polysilicon nanowires has been demonstrated as well (Lin et al, 2008). However, to the best of our knowledge, the utilization of organic thin film transistor (OTFT) for dopamine detection has not been investigated up to date.…”

Section: Introductionmentioning

confidence: 98%

Highly sensitive dopamine biosensors based on organic electrochemical transistors

Tang

Lin

Chan

et al. 2011

Biosensors and Bioelectronics

211

174

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Organic electrochemical transistors (OECTs) based on poly(3,4-ethylenedioxythiophene):poly(styrene sulfonic acid) (PEDOT:PSS) with different gate electrodes, including graphite, Au and Pt electrode, etc., have been used as dopamine sensor for the first time. The sensitivity of the OECT to dopamine depends on its gate electrode and operation voltage. We find that the device with a Pt gate electrode characterized at the gate voltage of 0.6 V shows the highest sensitivity. The detection limit of the device to dopamine is lower than 5 nM, which is one order of magnitude better than a conventional electrochemical measurement with the same Pt electrode. It is expected that OECT is a good candidate for low cost and highly sensitive biosensor for the detection of dopamine.

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Section: Introductionmentioning

confidence: 98%

Highly sensitive dopamine biosensors based on organic electrochemical transistors

Tang

Lin

Chan

et al. 2011

Biosensors and Bioelectronics

211

174

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“…Therefore, interferences and selectivity still need to be checked from a practical point of view for the selective detection of small compounds using CNTFET devices. Silicon nanowires fieldeffect transistors, which are closely related to CNTFET devices, have been also successfully used for detecting small molecules such as calcium ions (Bi et al, 2008) or dopamine (Lin et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Fast picomolar selective detection of bisphenol A in water using a carbon nanotube field effect transistor functionalized with estrogen receptor-α

Sánchez-Acevedo

Riu

Rius

2009

Biosensors and Bioelectronics

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“…As shown in Table 1, several studies have used NWFET-based biosensors for label-free, ultra-high-sensitivity, and real-time detection of various biological targets, including a single virus 2 , adenosine triphosphate and kinase binding 3 , neuronal signals 4 , metal ions 5,6 , bacterial toxins 7 , dopamine 8 , DNA [9][10][11] , RNA 12,13 , enzyme and cancer biomarkers [14][15][16][17][18][19] , human hormones 20 , and cytokines 21,22 . These studies have demonstrated that NWFET-based biosensors represent a powerful detection platform for a broad range of biological and chemical species in a solution.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Lin

Feng

et al. 2016

JoVE

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Surveillance using biomarkers is critical for the early detection, rapid intervention, and reduction in the incidence of diseases. In this study, we describe the preparation of polycrystalline silicon nanowire field-effect transistors (pSNWFETs) that serve as biosensing devices for biomarker detection. A protocol for chemical and biomolecular sensing by using pSNWFETs is presented. The pSNWFET device was demonstrated to be a promising transducer for real-time, label-free, and ultra-high-sensitivity biosensing applications. The source/drain channel conductivity of a pSNWFET is sensitive to changes in the environment around its silicon nanowire (SNW) surface. Thus, by immobilizing probes on the SNW surface, the pSNWFET can be used to detect various biotargets ranging from small molecules (dopamine) to macromolecules (DNA and proteins). Immobilizing a bioprobe on the SNW surface, which is a multistep procedure, is vital for determining the specificity of the biosensor. It is essential that every step of the immobilization procedure is correctly performed. We verified surface modifications by directly observing the shift in the electric properties of the pSNWFET following each modification step. Additionally, X-ray photoelectron spectroscopy was used to examine the surface composition following each modification. Finally, we demonstrated DNA sensing on the pSNWFET. This protocol provides step-by-step procedures for verifying bioprobe immobilization and subsequent DNA biosensing application. Video LinkThe video component of this article can be found at

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Ultrasensitive detection of dopamine using a polysilicon nanowire field-effect transistor

Cited by 71 publications

References 32 publications

Highly sensitive dopamine biosensors based on organic electrochemical transistors

Highly sensitive dopamine biosensors based on organic electrochemical transistors

Fast picomolar selective detection of bisphenol A in water using a carbon nanotube field effect transistor functionalized with estrogen receptor-α

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

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