Ultrasensitive Detection of Amines by a Trace Amine-Associated Receptor

Zhang, Jingji; Pacifico, Rodrigo; Cawley, Dillon; Feinstein, Paul; Bozza, Thomas

doi:10.1523/jneurosci.4299-12.2013

Cited by 94 publications

(106 citation statements)

References 37 publications

(84 reference statements)

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“…Moreover, TMA-induced attraction required TAAR5 and PEA-induced aversion required TAAR4 (22,23). Together with the finding that individual fish and human TAARs recognize volatile amines aversive to those species (17,(24)(25)(26), these findings have suggested that the evolutionary conservation of the TAAR family may be linked to an ability to induce innate behaviors to volatile amines.…”

Section: Numerous Taar Ligands and Other Odorants Induce Innate Respomentioning

confidence: 80%

“…At least some TAARs specifically recognize volatile amines, and two are required for behavioral attraction or avoidance to animal-derived amines (10,(21)(22)(23). In addition, one zebrafish TAAR ligand is aversive to fish (24), and one human TAAR detects an odorant aversive to humans as well as rotten fish (17,25,26). These observations have raised the possibility that the TAAR family may have an evolutionarily conserved ability to induce innate responses, particularly aversion.…”

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confidence: 99%

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Combinatorial effects of odorants on mouse behavior

Saraiva

Kondoh

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

128

160

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The mechanisms by which odors induce instinctive behaviors are largely unknown. Odor detection in the mouse nose is mediated by >1, 000 different odorant receptors (ORs) and trace amine-associated receptors (TAARs). Odor perceptions are encoded combinatorially by ORs and can be altered by slight changes in the combination of activated receptors. However, the stereotyped nature of instinctive odor responses suggests the involvement of specific receptors and genetically programmed neural circuits relatively immune to extraneous odor stimuli and receptor inputs. Here, we report that, contrary to expectation, innate odor-induced behaviors can be context-dependent. First, different ligands for a given TAAR can vary in behavioral effect. Second, when combined, some attractive and aversive odorants neutralize one another's behavioral effects. Both a TAAR ligand and a common odorant block aversion to a predator odor, indicating that this ability is not unique to TAARs and can extend to an aversive response of potential importance to survival. In vitro testing of single receptors with binary odorant mixtures indicates that behavioral blocking can occur without receptor antagonism in the nose. Moreover, genetic ablation of a single receptor prevents its cognate ligand from blocking predator odor aversion, indicating that the blocking requires sensory input from the receptor. Together, these findings indicate that innate odor-induced behaviors can depend on context, that signals from a single receptor can block innate odor aversion, and that instinctive behavioral responses to odors can be modulated by interactions in the brain among signals derived from different receptors.olfaction | behavior | TAAR | odorants

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Section: Numerous Taar Ligands and Other Odorants Induce Innate Respomentioning

confidence: 80%

mentioning

confidence: 99%

Combinatorial effects of odorants on mouse behavior

Saraiva

Kondoh

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

128

160

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show abstract

“…Odorant receptors (ORs) are encoded by a large multigene family that is evolutionarily conserved among vertebrates, but most extensively studied in mice. Mice have ϳ1000 different ORs, whereas humans have ϳ350 (Glusman et al, 2001;Zhang and Firestein, 2002;Godfrey et al, 2004;Malnic et al, 2004;Niimura and Nei, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Like ORs, TAARs are evolutionarily conserved from fish to humans (Gloriam et al, 2005). At least three mouse TAARs recognize volatile biogenic amines that cause behavioral attraction or aversion, suggesting that some TAARs detect social cues (Liberles and Buck, 2006;Li et al, 2013;Zhang J. et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Olfactory Receptor Patterning in a Higher Primate

et al. 2014

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The mammalian olfactory system detects a plethora of environmental chemicals that are perceived as odors or stimulate instinctive behaviors. Studies using odorant receptor (OR) genes have provided insight into the molecular and organizational strategies underlying olfaction in mice. One important unanswered question, however, is whether these strategies are conserved in primates. To explore this question, we examined the macaque, a higher primate phylogenetically close to humans. Here we report that the organization of sensory inputs in the macaque nose resembles that in mouse in some respects, but not others. As in mouse, neurons with different ORs are interspersed in the macaque nose, and there are spatial zones that differ in their complement of ORs and extend axons to different domains in the olfactory bulb of the brain. However, whereas the mouse has multiple discrete band-like zones, the macaque appears to have only two broad zones. It is unclear whether the organization of OR inputs in a rodent/primate common ancestor degenerated in primates or, alternatively became more sophisticated in rodents. The mouse nose has an additional small family of chemosensory receptors, called trace amine-associated receptors (TAARs), which may detect social cues. Here we find that TAARs are also expressed in the macaque nose, suggesting that TAARs may also play a role in human olfactory perception. We further find that one human TAAR responds to rotten fish, suggesting a possible role as a sentinel to discourage ingestion of food harboring pathogenic microorganisms.

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“…Like ORs, TAARs are evolutionarily conserved in vertebrates, suggesting that they may serve a distinct function. Ligands found thus far for TAARs are volatile amines, including several in mouse or predator urine (5,14,15). Ligands for a few mouse, fish, and human TAARs elicit aversive or attractive behaviors in their respective species, hinting at a conserved ability of TAARs to stimulate innate responses of potentially adaptive significance (5,6,14,16,17).…”

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confidence: 99%

Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments

Yoon

Ragoczy

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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The olfactory system translates a vast array of volatile chemicals into diverse odor perceptions and innate behaviors. Odor detection in the mouse nose is mediated by 1,000 different odorant receptors (ORs) and 14 trace amine-associated receptors (TAARs). ORs are used in a combinatorial manner to encode the unique identities of myriad odorants. However, some TAARs appear to be linked to innate responses, raising questions about regulatory mechanisms that might segregate OR and TAAR expression in appropriate subsets of olfactory sensory neurons (OSNs). Here, we report that OSNs that express TAARs comprise at least two subsets that are biased to express TAARs rather than ORs. The two subsets are further biased in Taar gene choice and their distribution within the sensory epithelium, with each subset preferentially expressing a subgroup of Taar genes within a particular spatial domain in the epithelium. Our studies reveal one mechanism that may regulate the segregation of Olfr (OR) and Taar expression in different OSNs: the sequestration of Olfr and Taar genes in different nuclear compartments. Although most Olfr genes colocalize near large central heterochromatin aggregates in the OSN nucleus, Taar genes are located primarily at the nuclear periphery, coincident with a thin rim of heterochromatin. Taar-expressing OSNs show a shift of one Taar allele away from the nuclear periphery. Furthermore, examination of hemizygous mice with a single Taar allele suggests that the activation of a Taar gene is accompanied by an escape from the peripheral repressive heterochromatin environment to a more permissive interior chromatin environment. olfactory receptor genes | Taar genes | nuclear organization

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Ultrasensitive Detection of Amines by a Trace Amine-Associated Receptor

Cited by 94 publications

References 37 publications

Combinatorial effects of odorants on mouse behavior

Combinatorial effects of odorants on mouse behavior

Olfactory Receptor Patterning in a Higher Primate

Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments

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