Ultrasensitive amperometric immunosensor for PSA detection based on Cu2O@CeO2-Au nanocomposites as integrated triple signal amplification strategy

Li, Faying; Li, Yueyun; Feng, Jinhui; Dong, Yunhui; Wang, Ping; Chen, Lei; Chen, Zhiwei; Liu, Hui; Wei, Qin

doi:10.1016/j.bios.2016.09.018

Cited by 106 publications

(36 citation statements)

References 51 publications

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“…Also using AuNPs for their catalytic properties toward H 2 O 2 reduction, Li et al [143] very recently (2017) described an immunosensor for PSA detection with amino-functionalized Cu 2 O@CeO 2 core-shell NPs able to bind AuNPs through Au-N bonds. These NPs brought a better electrocatalytic activity towards the reduction of H 2 O 2 (added as redox probe in solution) than single Cu 2 O or AuNPs alone.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in Electrochemical Immunosensors

Piro

Reisberg

2017

Sensors

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Immunosensors have experienced a very significant growth in recent years, driven by the need for fast, sensitive, portable and easy-to-use devices to detect biomarkers for clinical diagnosis or to monitor organic pollutants in natural or industrial environments. Advances in the field of signal amplification using enzymatic reactions, nanomaterials such as carbon nanotubes, graphene and graphene derivatives, metallic nanoparticles (gold, silver, various oxides or metal complexes), or magnetic beads show how it is possible to improve collection, binding or transduction performances and reach the requirements for realistic clinical diagnostic or environmental control. This review presents these most recent advances; it focuses first on classical electrode substrates, then moves to carbon-based nanostructured ones including carbon nanotubes, graphene and other carbon materials, metal or metal-oxide nanoparticles, magnetic nanoparticles, dendrimers and, to finish, explore the use of ionic liquids. Analytical performances are systematically covered and compared, depending on the detection principle, but also from a chronological perspective, from 2012 to 2016 and early 2017.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in Electrochemical Immunosensors

Piro

Reisberg

2017

Sensors

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“…This modified electrode not only provided enough amine groups for biomarker immobilization but also showed the high recovery efficiency because of the peptides labeled with golden nanorods (acted as an acceptor) [ 49 ]. Taking advantage of the synergetic effect which was presented from the Cu 2 O@CeO 2 core-shell decorated with GNPs (Cu 2 O@CeO 2 -Au), Li et al showed a better electrocatalytic activity to reduce hydrogen peroxide (H 2 O 2 ) than single Cu 2 O, GNPs, or Cu 2 O@CeO 2 [ 50 ]. Govindasamy et al fabricated a progesterone sensor with cyclic voltammetry and amperometric measurement; electrodes of this sensor were modified by WO 3 NBs@GR nanocomposite electrocatalyst [ 51 ].…”

Section: Electrochemical Biomarker Sensorsmentioning

confidence: 99%

Recent Progress of Biomarker Detection Sensors

Liu

Cui

2020

Research

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Early cancer diagnosis and treatment are crucial research fields of human health. One method that has proven efficient is biomarker detection which can provide real-time and accurate biological information for early diagnosis. This review presents several biomarker sensors based on electrochemistry, surface plasmon resonance (SPR), nanowires, other nanostructures, and, most recently, metamaterials which have also shown their mechanisms and prospects in application in recent years. Compared with previous reviews, electrochemistry-based biomarker sensors have been classified into three strategies according to their optimizing methods in this review. This makes it more convenient for researchers to find a specific fabrication method to improve the performance of their sensors. Besides that, as microfabrication technologies have improved and novel materials are explored, some novel biomarker sensors—such as nanowire-based and metamaterial-based biomarker sensors—have also been investigated and summarized in this review, which can exhibit ultrahigh resolution, sensitivity, and limit of detection (LoD) in a more complex detection environment. The purpose of this review is to understand the present by reviewing the past. Researchers can break through bottlenecks of existing biomarker sensors by reviewing previous works and finally meet the various complex detection needs for the early diagnosis of human cancer.

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“…These devices can be miniaturized and allow in situ analysis with real‐time detection, important characteristics for the development of point‐of‐care testing . In particular, label‐free immunosensors have the advantage that their simple preparation and procedure does not require a complicated labeling process . In systems using an unlabeled antibody (label‐free) it is necessary to use a redox probe (electrochemically active species).…”

Section: Introductionmentioning

confidence: 99%

“…In the search for the development of an electrochemical immunosensor with high analytical performance, various materials have been explored, including graphene , carbon nanotubes , polymers , metal nanoparticles , and liquid crystals . Metallic nanoparticles have great potential for application in immunosensors, mainly due to their large specific surface area, good biocompatibility and excellent electrical conductivity.…”

Section: Introductionmentioning

confidence: 99%

“…Li et al . developed a label‐free electrochemical immunosensor for the quantitative detection of PSA based on amino functionalized cuprous oxide@ceric dioxide (Cu 2 O@CeO 2 ‐NH 2 ) core‐shell nanocomposites and gold nanoparticles (Au NPs). Under the optimal conditions, the proposed immunosensor exhibited a wide linear range from 0.1 pg mL −1 to 100 ng mL −1 with a low detection limit of 0.03 pg mL −1 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Heparin‐gold Nanoparticles and Liquid Crystal Applied in Label‐free Electrochemical Immunosensor for Prostate‐specific Antigen

et al. 2017

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A label‐free electrochemical immunosensor based on the liquid crystal (E)‐1‐decyl‐4‐[(4‐decyloxyphenyl)diazenyl]pyridinium bromide (Br−Py), together with heparin‐stabilized gold nanoparticles (AuNP‐Hep) and Nafion is proposed for the determination of prostate‐specific antigen (PSA). The Br−Py liquid crystal presented redox properties and good film‐forming abilities on the electrode surface, and thus it is a suitable alternative as a redox probe for a label‐free electrochemical immunosensor, which could simplify the analysis methodology. The stepwise construction of the immunosensor and the incubation process (immunocomplex formation) were characterized by voltammetry and electrochemical impedance spectroscopy. The proposed immunosensor could directly detect PSA concentrations in the incubation samples, based on the suppression of the Br−Py redox peak (‘base peak’) current. After optimization, the immunosensor exhibited a linear response to PSA concentrations in the range of 0.1 to 50 ng mL−1, with a calculated detection limit of 0.08 ng mL−1. The reproducibility (coefficient of variance less than 3.0 %), selectivity and accuracy of the methodology were adequate. The immunosensor was satisfactorily applied in the quantification of PSA in human blood plasma samples.

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Ultrasensitive amperometric immunosensor for PSA detection based on Cu2O@CeO2-Au nanocomposites as integrated triple signal amplification strategy

Cited by 106 publications

References 51 publications

Recent Advances in Electrochemical Immunosensors

Recent Advances in Electrochemical Immunosensors

Recent Progress of Biomarker Detection Sensors

Heparin‐gold Nanoparticles and Liquid Crystal Applied in Label‐free Electrochemical Immunosensor for Prostate‐specific Antigen

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