Ultrapure laser-synthesized Si nanoparticles with variable oxidation states for biomedical applications

Al-Kattan, Ahmed; Ryabchikov, Yury V.; Baâti, Tarek; Chirvony, Vladimir S.; Sánchez-Royo, Juan F.; Sentís, M.; Braguer, Diane; Timoshenko, V. Yu.; Estève, Marie‐Anne; Kabashin, Andrei V.

doi:10.1039/c6tb02623k

Cited by 68 publications

(94 citation statements)

References 29 publications

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“…As an example, some previous studies used designed SERS probes based on silica (SiO 2 )‐coated plasmonic structures, including gold nanorods and nanostars , to improve the biocompatibility and efficiency of SERS probes. The inclusion of nonoxidized crystalline silicon (Si) fraction into composition of SERS probes is expected to further improve the biocompatibility of these probes, as Si is one of the essential materials in biological systems, which does not provoke any toxic effects even under massive injection in vitro or in vivo . In addition, in contrast to silica, silicon can provide a distinct Raman scattering peak around 520/cm, which was clearly visible in our tests (Figure (B)).…”

Section: Resultsmentioning

confidence: 78%

“…Crystalline silicon (Si) is a prominent example of such material, which is one of the essential elements in live organism and is present in many biological tissues in the form of orthosilicate (SiO 4 4− ) . We recently showed that contamination‐free laser‐synthesized Si NPs are not only well compatible with biological systems in vitro and in vivo , but are also biodegradable as they decay in aqueous environment into orthosilicic acid Si(OH) 4 and excrete from biological systems without any harmful effects . We envision that the coating of plasmon‐supporting SERS probes by Si shell could improve the compatibility of these probes with biological systems and bring novel functionalities.…”

Section: Introductionmentioning

confidence: 99%

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Bare laser‐synthesized Au‐based nanoparticles as nondisturbing surface‐enhanced Raman scattering probes for bacteria identification

Kögler

Ryabchikov

Uusitalo

et al. 2018

Journal of Biophotonics

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The ability of noble metal-based nanoparticles (NPs) (Au, Ag) to drastically enhance Raman scattering from molecules placed near metal surface, termed as surface-enhanced Raman scattering (SERS), is widely used for identification of trace amounts of biological materials in biomedical, food safety and security applications. However, conventional NPs synthesized by colloidal chemistry are typically contaminated by nonbiocompatible by-products (surfactants, anions), which can have negative impacts on many live objects under examination (cells, bacteria) and thus decrease the precision of bioidentification. In this article, we explore novel ultrapure laser-synthesized Au-based nanomaterials, including Au NPs and AuSi hybrid nanostructures, as mobile SERS probes in tasks of bacteria detection. We show that these Au-based nanomaterials can efficiently enhance Raman signals from model R6G molecules, while the enhancement factor depends on the content of Au in NP composition. Profiting from the observed enhancement and purity of laser-synthesized nanomaterials, we demonstrate successful identification of 2 types of bacteria (Listeria innocua and Escherichia coli). The obtained results promise less disturbing studies of biological systems based on good biocompatibility of contamination-free laser-synthesized nanomaterials.

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Section: Resultsmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Bare laser‐synthesized Au‐based nanoparticles as nondisturbing surface‐enhanced Raman scattering probes for bacteria identification

Kögler

Ryabchikov

Uusitalo

et al. 2018

Journal of Biophotonics

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“…Making possible fast production of bare (uncovered) NPs in colloidal state with almost any composition, pulsed laser ablation in liquids [12][13][14][15][16][17] (PLAL) provides one of best alternatives to satisfy the above-stated demands. As an example, we recently showed that the technique of femtosecond laser ablation in liquids can be used for the fabrication of a variety of ultrapure, biologically-friendly nanomaterials, including gold NPs [16,[18][19][20][21][22], titanium nitride (TiN) NPs [23], silicon NPs [24][25][26][27] and organic polymer NPs [28]. In many cases, such nanoparticles can provide superior properties for catalytic [20], energy and biomedical [29,30] applications, compared to nanomaterials synthesized by conventional chemical methods, and other methods.…”

Section: Sm Oxide Powder and Preparation Of Target For Ablationmentioning

confidence: 99%

Laser-Ablative Synthesis of Isotope-Enriched Samarium Oxide Nanoparticles for Nuclear Nanomedicine

et al. 2019

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Nuclear nanomedicine is an emerging field, which utilizes nanoformulations of nuclear agents to increase their local concentration at targeted sites for a more effective nuclear therapy at a considerably reduced radiation dosage. This field needs the development of methods for controlled fabrication of nuclear agents carrying nanoparticles with low polydispersity and with high colloidal stability in aqueous dispersions. In this paper, we apply methods of femtosecond (fs) laser ablation in deionized water to fabricate stable aqueous dispersion of 152 Sm-enriched samarium oxide nanoparticles (NPs), which can capture neutrons to become 153 Sm beta-emitters for nuclear therapy. We show that direct ablation of a 152 Sm-enriched samarium oxide target leads to widely size-and shape-dispersed populations of NPs with low colloidal stability. However, by applying a second fs laser fragmentation step to the dispersion of initially formed colloids, we achieve full homogenization of NPs size characteristics, while keeping the same composition. We also demonstrate the possibility for wide-range tuning of the mean size of Sm-based NPs by varying laser energy during the ablation or fragmentation step. The final product presents dispersed solutions of samarium oxide NPs with relatively narrow size distribution, having spherical shape, a controlled mean size between 7 and 70 nm and high colloidal stability. The formed NPs can also be of importance for catalytic and biomedical applications.

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“…Crystalline Si NPs were prepared by biologically friendly methods of microwave (MW) plasma‐assisted decomposition of silicon tetrafluoride (SiF 4 ) and laser ablation/fragmentation of microparticles of c‐Si in deionized water . The first method was used to fabricate high‐quality Si NPs of a fixed size (see details in the Experimental Section).…”

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confidence: 99%

Bi‐Modal Nonlinear Optical Contrast from Si Nanoparticles for Cancer Theranostics

Kharin

Lysenko

Rogov

et al. 2019

Advanced Optical Materials

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Having negligible toxicity compared to quantum dots based on compound semiconductors [1,2] and being capable of providing efficient imaging and therapeutic functionalities based on its unique physicochemical characteristics, [3][4][5] nanosilicon occupies a particularly important niche related to biological applications. The imaging functionality of nanosilicon typically employs photoluminescence (PL) of quantum-confined excitonic states in silicon (Si) nanocrystals (NCs) with sizes smaller than the exciton Bohr's radius (≈5 nm for the bulk crystalline Si (c-Si)), which enables tracking the presence of Si nanoparticles (NPs) in cells or tissues. [6][7][8][9][10][11][12][13] On the other hand, Si NPs can serve as efficient sensitizers of local heating under external stimuli to initiate hyperthermia-based therapies. As an example, Presenting a safe alternative to conventional compound quantum dots and other functional nanostructures, nanosilicon can offer a series of breakthrough hyperthermia-based therapies under near-infrared, radiofrequency, ultrasound, etc., excitation, but the size range to sensitize these therapies is typically too large (>10 nm) to enable efficient imaging functionality based on photoluminescence properties of quantum-confined excitonic states. Here, it is shown that large Si nanoparticles (NPs) are capable of providing two-photon excited luminescence (TPEL) and second harmonic generation (SHG) responses, much exceeding that of smaller Si NPs, which promises their use as probes for bi-modal nonlinear optical bioimaging. It is finally demonstrated that the combination of TPEL and SHG channels makes possible efficient tracing of both separated Si NPs and their aggregations in different cell compartments, while the resolution of such an approach is enough to obtain 3D images. The obtained bi-modal contrast provides lacking imaging functionality for large Si NPs and promises the development of novel cancer theranostic modalities on their basis.

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Ultrapure laser-synthesized Si nanoparticles with variable oxidation states for biomedical applications

Abstract: We use femtosecond laser fragmentation to fabricate ultrapure bare Si-based nanoparticles (Si-NPs) for biomedical applications.

Cited by 68 publications

References 29 publications

Bare laser‐synthesized Au‐based nanoparticles as nondisturbing surface‐enhanced Raman scattering probes for bacteria identification

Bare laser‐synthesized Au‐based nanoparticles as nondisturbing surface‐enhanced Raman scattering probes for bacteria identification

Laser-Ablative Synthesis of Isotope-Enriched Samarium Oxide Nanoparticles for Nuclear Nanomedicine

Bi‐Modal Nonlinear Optical Contrast from Si Nanoparticles for Cancer Theranostics

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