Ultrapulse CO2Used for the Successful Treatment of Basal Cell Carcinomas Found in Patients with Basal Cell Nevus Syndrome

Nouri, Keyvan; Chang, Attica; Trent, Jennifer T.; Jimenez, Gloria

doi:10.1046/j.1524-4725.2002.01080.x

Cited by 32 publications

(6 citation statements)

References 24 publications

(39 reference statements)

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“…The treatment with CO 2 laser allows an effective vaporizing of affected areas, followed by the removal of the heat-separated tissue [ 1 ]. The UltraPulse system uses high fluencies that are delivered in short pulses to minimize nonspecific thermal damage to the adjacent tissues, permitting a precise treatment with minimal destruction of normal surrounding tissue, decreasing postoperative pain, decreasing recurrence, shortened healing time, bloodless field, and better cosmesis [ 3 ]. To ensure a faster and greater therapeutic response, we arbitrarily added MAL-PDT treatment in the same sessions [ 1 , 2 ].…”

Section: Discussion/conclusionmentioning

confidence: 99%

UltraPulse Carbon Dioxide Laser Plus Methyl Aminolevulinate-Photodynamic Therapy for the Treatment of Penile Cancer

et al. 2022

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The treatment of early-stage penile carcinoma is usually represented by wide excision or partial penectomy with or without inguinal lymph node dissection. However, laser ablation of the tumor may have a prominent role as an organ-sparing approach. In this regard, the combination of UltraPulse CO2 laser and photodynamic therapy (PDT) may be a valid option, especially when surgery is not feasible or refused. UltraPulse CO2 laser allows for the formation of gentle cutaneous abrasion that destroys the malignant tissue and, at the same time, improving the uptake of methyl aminolevulinate and amplifying the photochemical reaction of PDT in the tumor and surrounding tissue.

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Section: Discussion/conclusionmentioning

confidence: 99%

UltraPulse Carbon Dioxide Laser Plus Methyl Aminolevulinate-Photodynamic Therapy for the Treatment of Penile Cancer

et al. 2022

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“…Ablative lasers, including carbon dioxide (CO 2 ) and erbium yttrium aluminum garnet (Er:YAG) lasers, have wavelengths that lie within the infrared range (10,600 and 2,940 nm, respectively), selectively targeting water and causing tissue ablation. The authors identified 11 studies on CO 2 alone, [20][21][22][23][24][25][26][27][28][29][30] 1 study on CO 2 combined with PDL, 31 2 studies on the use of CO 2 with concomitant noninvasive imaging, 32,33 and 2 studies on Er:YAG with noninvasive imaging (See Supplemental Digital Content 1, Table 1, http://links. lww.com/DSS/B439).…”

Section: Ablative Lasersmentioning

confidence: 99%

“…Several studies have evaluated pulsed CO 2 in the treatment of BCCs. [23][24][25][26][27][28][29][30] Five studies, published over 20 years ago, with sample sizes ranging from 1 to 140 tumors, reported clearance rates between 70.6% and 100% at a maximal follow-up of 3 years. [23][24][25][26][27] More recently, 2 case series and 1 randomized controlled trial examined the efficacy of pulsed CO 2 in treating BCC, with clearance rates between 78.8% and 95.2%.…”

Section: Co 2 Lasermentioning

confidence: 99%

Lasers for the Treatment of Nonmelanoma Skin Cancer: A Systematic Review of the Literature

Rosenthal,

Juhasz,

Chang

et al. 2024

Dermatol Surg

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BACKGROUND Lasers may present an alternative treatment modality for the management of nonmelanoma skin cancer (NMSC). OBJECTIVE To investigate lasers as a definitive treatment of NMSC. METHODS A comprehensive search was performed on MEDLINE, the Cochrane Library, and the National Institutes of Health (www.clinicaltrials.gov). The Preferred Reporting Items for Systematic Reviews and Meta-Analysis was used to finalize a list of relevant literature studies evaluating the role of laser therapy for NMSC. Articles published through May 1, 2023, were included. RESULTS The authors identified 37 studies investigating nonablative and ablative lasers alone and in combination with other lasers, noninvasive imaging, and additional modalities for the treatment of basal cell carcinomas, 10 focusing on squamous cell carcinoma in situ and 3 focusing on the treatment of both basal and squamous cell carcinomas. CONCLUSION Although surgical management continues to be superior to laser therapy for the management of high-risk and cosmetically sensitive tumors, laser therapy may be an acceptable alternative for low-risk lesions on the trunk and extremities. However, further studies are needed to optimize parameters, determine maximal efficacy, and provide long-term follow-up before the adoption of laser therapy for NMSC into daily clinical practice.

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“…In a case series of 3 Gorlin patients, ultrapulse CO 2 laser achieved histological clearance of BCCs on the face, trunk, and extremities. 27 Another case series had 6 Gorlin patients for whom they used fully ablative CO 2 laser to treat between 14 and 110 lesions in 1 session under local anesthesia. Treatment was limited to the lesion only, with a range of 2 to 6 passes until an endpoint of punctate bleeding was achieved.…”

Section: Ablative Lasersmentioning

confidence: 99%

An Institutional Experience of a Tertiary Referral Center in Surgically Managing Patients With Gorlin Syndrome

Dany,

Walker,

Miller

et al. 2023

Dermatol Surg

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BACKGROUND The lifetime risk for basal carcinoma (BCC) is 90% in patients with Gorlin syndrome, also known as basal cell nevus syndrome. Compared with non-Gorlin patients, Gorlin patients often develop BCCs at a younger age and in greater numbers up to 500 BCCs in a lifetime. OBJECTIVE To review the options available for Gorlin patients and highlight existing knowledge gaps where future studies are indicated to optimize the care of this unique population. METHODS We review the current literature on managing patients with Gorlin syndrome from the lens of a dermatologic surgeon. RESULTS Although Mohs surgery is still the gold standard for large and aggressive BCCs, other less-invasive approaches may be considered for smaller, more numerous lesions. As dermatologic surgeons, we must be open to the full spectrum of surgical and nonsurgical options to individualize treatment and optimize patients' quality of life. Without maintaining a balance between optimal cure rate and volume management, Gorlin patients become at risk for surgical burn out and loss to follow-up. CONCLUSION Gorlin patients undergo numerous surgeries especially on the central face which can lead to disfigurement and reduce the quality of life. Identifying gaps in the current literature, continuing ongoing research, and eventually establishing appropriate guidelines that help to guide the formation of an individualized treatment plan is crucial in developing a balance between conservative and complex treatments for this population.

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Ultrapulse CO₂Used for the Successful Treatment of Basal Cell Carcinomas Found in Patients with Basal Cell Nevus Syndrome

Abstract: Ultrapulse CO2 laser can be used to effectively treat small BCCs in low-risk areas associated with BCNS with minimal posttreatment scarring.

Cited by 32 publications

References 24 publications

UltraPulse Carbon Dioxide Laser Plus Methyl Aminolevulinate-Photodynamic Therapy for the Treatment of Penile Cancer

UltraPulse Carbon Dioxide Laser Plus Methyl Aminolevulinate-Photodynamic Therapy for the Treatment of Penile Cancer

Lasers for the Treatment of Nonmelanoma Skin Cancer: A Systematic Review of the Literature

An Institutional Experience of a Tertiary Referral Center in Surgically Managing Patients With Gorlin Syndrome

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