Ultramcromethod for estimation of total glutathione in dried blood spots on filter paper

Orfanos, Adam P.; Naylor, Edwin W.; Guthrie, Robert

doi:10.1016/0003-2697(80)90278-x

Cited by 11 publications

(6 citation statements)

References 12 publications

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“…Since CH was known to be of higher incidence than PKU, its detection from the FPKU specimen_ vastly improved the cost-effectiveness of the screening process. During the 1970s, DBS procedures were also developed to screen newborns for haemoglobinopathies (Garrick et al 1973), thyrotropin (TSH) (Dussault et al 1976) and 21-hydroxylase-deficient congenital adrenal hyperplasia (CAH) (Pang et al 1977) in addition to many other metabolic conditions (Murphey et al 1972;Naylor et al 1977;Orfanos et al 1978). The fact that automated punching could simultaneously initiate four testing processes, with little or no increase in personnel, led many programmes to consider expansion.…”

Section: The United States Of Americamentioning

confidence: 98%

Newborn screening in North America

Therrell

Adams²

2007

J of Inher Metab Disea

119

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Newborn screening in North America dates to the early work of Bob Guthrie in the USA. Screening programmes in both the USA and Canada began in the early 1960s, with documented programmes in both countries as early as 1962. Throughout the 1960s and 1970s, many of the screening tests that later became part of routine screening around the world were developed in US and Canadian laboratories, including tests for phenylketonuria, other inborn errors of metabolism, congenital hypothyroidism, congenital adrenal hyperplasia, and haemoglobinopathies. An automated punching machine developed in the USA facilitated screening expansion by significantly reducing sample preparation time and effort. US and Canadian programmes were leaders in applying computerized data management to newborn screening in the 1980s. In the 1990s, DNA and tandem mass spectrometry testing protocols were developed in the USA and applied to newborn screening. US programmes have continually expanded over time, while most Canadian programmes have not. With impetus from private laboratories and professional and consumer groups, many US programmes now screen for more than 50 conditions and there is increased expansion activity in Canada. NBS research in the USA is focused on improving system efficiency and translating other genetic testing to NBS, particularly where new technologies and treatment therapies exist. Although national newborn screening policies do not exist in either Canada or the USA, there are intense efforts to provide uniform access to screening nationwide in both countries. New partnerships between health professionals, consumers and politicians are benefiting the overall screening systems in both countries.

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Section: The United States Of Americamentioning

confidence: 98%

Newborn screening in North America

Therrell

Adams²

2007

J of Inher Metab Disea

119

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“…Glucose Quantification of blood glucose levels Reflectometery [173] 34. Glutathione Ultramicro method for determination of total glutathione Colorimetry [174] 35. Guanidinoacetate and creatine Diagnosis of guanidinoacetate methyltransferase and arginine glycine amidinotransferase deficiencies for newborn screening Flow injection analysis-MS/MS [175] 36.…”

Section: Estradiol Progesterone and Testosteronementioning

confidence: 99%

Dried blood spots: Concepts, present status, and future perspectives in bioanalysis

Sharma

Jaiswal

Shukla

et al. 2014

Drug Testing and Analysis

139

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Over the past several years, dried blood spot (DBS) sampling technique has emerged as a pertinent method in both qualitative and quantitative bioanalysis context. In the DBS method, the blood sample is directly soaked on to a paper (with or without treatment). After drying it can be analyzed by modern analytical, immunological, or genomic detection systems. Several advantages of the DBS technique such as low blood volume requirement, transportation and storage without special treatment, better analytes stability, enhanced clinical cooperation in clinical trials, and reduced unforeseeable exposure of analysts to biohazards, make it the most appropriate blood sampling technique. This review illustrates the information available on the DBS method which may serve as a single window for investigators in the field of bioanalysis. Also, it explores the proficiency and appliance of the DBS method in pharmacokinetic (PK), therapeutic drug monitoring (TDM), toxicokinetic (TK), metabolomic, and disease diagnosis.

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“…The method recovery was >95%, the inter-and intra-assay precision was <8 and <9%, respectively. Orfanos et al (1980) reported a method for quantitative determination of glutathione from DBS samples. The sample preparation involved elution of the analyte from a small disk of dried blood spotted on filter paper.…”

Section: Review Of Applicationsmentioning

confidence: 99%

The Use of Dried Blood Spots for Concentration Assessment in Pharmacokinetic Evaluations

Majumdar¹,

Howard

2011

Pharmacokinetics in Drug Development

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This chapter reviews the technology and application of Dried Blood Spot (DBS) sampling techniques. In part due to its relative simplicity, DBS has begun to receive increased use in the pharmaceutical industry, particularly where blood or plasma sample volumes are small, are difficult to collect, store, process, or transport. This chapter presents methods and techniques, highlights applications, and discusses benefits and drawbacks associated with its use in pharmacokinetics.

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Ultramcromethod for estimation of total glutathione in dried blood spots on filter paper

Cited by 11 publications

References 12 publications

Newborn screening in North America

Newborn screening in North America

Dried blood spots: Concepts, present status, and future perspectives in bioanalysis

The Use of Dried Blood Spots for Concentration Assessment in Pharmacokinetic Evaluations

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