Ultrahigh-Resolution Optical Coherence Tomography of Surgically Closed Macular Holes

Ko, Tony H.

doi:10.1001/archopht.124.6.827

Cited by 115 publications

(69 citation statements)

References 45 publications

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“…The findings of the present report and other publications 20,21 describing SD-OCT findings of successfully closed MHs indicate that ELM can recover or 'heal', by regaining its continuity after MH surgery. The process of successful reformation of zonular adherentes between inner segments and Mü ller cells after MH, contributing to the ELM 'healing', appears to be a necessary condition for structural and functional restoration of the impaired photoreceptor layer.…”

Section: Discussionsupporting

confidence: 75%

External limiting membrane and visual outcome in macular hole repair: spectral domain OCT analysis

Landa

Gentile

Garcia

et al. 2011

Eye

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Purpose To investigate the relationship between postoperative visual acuity and integrity of the external limiting membrane (ELM) and inner segment-outer segment (IS-OS) junction layers, using spectral domain optical coherence tomography (SD-OCT), in eyes with macular holes (MHs) following surgical repair. Methods Medical charts of MH-operated cases were retrospectively identified and reviewed. The primary outcome measures were best-corrected visual acuity (BCVA) and the status of the ELM and IS-OS lines, using SD-OCT, at 6 weeks and 6 months postoperatively. Results Sixty-two eyes of 62 patients were included. At 6 weeks following surgery, out of 56 (90.3%) eyes with successful MH closure: 0 eyes showed the combination of disrupted ELM and continuous IS-OS layers; 7 eyes (12.5%) demonstrated continuity of both ELM and IS-OS (ELM c /IS-OS c group); 29 eyes (51.8%) had continuous ELM with discontinuous IS-OS layers (ELM c /IS-OS d group); and 20 eyes (35.7%) had discontinuities in both the layers (ELM d /IS-OS d group). The ELM d /IS-OS d group had the lowest visual gain at 6 months (P ¼ 0.03). At 6 months, a restoration of the integrity of IS-OS layer was observed in 51.7% eyes in the ELM c /IS-OS d group and in 5% in the ELM d /IS-OS d group (P ¼ 0.001). Conclusions When both ELM and IS-OS layers showed disruptions 6 weeks postoperatively, a significantly worse BCVA was measured at 6 months, compared with the eyes with only IS-OS disruptions, detected 6 weeks following surgery. The integrity of the ELM layer appears to be a critical factor for the restoration of the photoreceptor layer and for predicting a successful visual outcome following MH repair.

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Section: Discussionsupporting

confidence: 75%

External limiting membrane and visual outcome in macular hole repair: spectral domain OCT analysis

Landa

Gentile

Garcia

et al. 2011

Eye

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“…31,32 Further longitudinal studies and clinicopathologic analyses would clarify the cellular or histologic components of this OCT finding.…”

Section: Discussionmentioning

confidence: 90%

Characterization of Inner Retinal Spots With Inverted Reflectivity on En Face Optical Coherence Tomography in Diabetic Retinopathy

Yoza

Murakami

Uji

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Yoza R, Murakami T, Uji A, et al. Characterization of inner retinal spots with inverted reflectivity on en face optical coherence tomography in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2016;57:186257: -187057: . DOI:10.1167 PURPOSE. The purpose of this study was to characterize inner retinal spots with inverted reflectivity on en face images of swept-source optical coherence tomography (SS-OCT) in diabetic retinopathy (DR). METHODS.We retrospectively reviewed seventy-five eyes of 75 patients with DR (15 eyes with individual grades of DR severity). We obtained three-dimensional images (6 3 6 mm) centered on the fovea, followed by the generation of en face images. We investigated the morphologic characteristics of spots with inverted reflectivity, which had lower reflectivity than the surrounding areas in the nerve fiber layer (NFL) and higher reflectivity in the ganglion cell layer (GCL).RESULTS. Thirty-seven of 45 eyes (82.2%) with moderate nonproliferative diabetic retinopathy (NPDR) or more severe grades were accompanied with well-defined spots with inverted reflectivity, whereas 30 eyes with no apparent retinopathy or mild NPDR had no such lesions. These spots had various shapes in the NFL and GCL on en face OCT images; the mean area was 0.126 6 0.052 mm 2 at the NFL level. In all 75 eyes, 153 of 184 spots (83.2%) were localized in the NFL and GCL, whereas 31 spots (16.8%) extended to retinal layers deeper than the GCL. One-hundred sixty-nine spots (91.8%) were not visible on color fundus photographs, and 15 spots (8.2%) were accompanied by whitish-yellow lesions in the corresponding areas. In 45 eyes for which fluorescein angiography images were obtained, mild hypofluorescence was seen in 156 spots (84.8%) and focal nonperfused areas in 17 spots (9.2%).CONCLUSIONS. En face images of SS-OCT showed spots with inverted reflectivity in the NFL and GCL in DR.

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“…Ultra-high-resolution images of retinal architecture obtained with SD OCT have been shown to detect retinal pathologic features at a higher frequency than other OCT systems. 17 Despite the potential benefit of OCT imaging of the infant retina to evaluate disease processes and injury, until now, it has been difficult to accomplish this with a tabletop chin-rest system.…”

Section: Discussionmentioning

confidence: 99%

Imaging the Infant Retina with a Hand-held Spectral-Domain Optical Coherence Tomography Device

Scott

Farsiu

Enyedi

et al. 2009

American Journal of Ophthalmology

155

109

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• PURPOSE: To evaluate and treat infant retina through the use of a hand-held spectral-domain optical coherence tomography (SD OCT) device in selected cases of Shaken Baby syndrome (SBS).• DESIGN: Observational case series.• METHODS: A novel SD OCT system was optimized and evaluated for infant imaging. An adult eye was imaged with both a standard clinical SD OCT system and the hand-held system. Four eyes of two infants with a history of SBS were imaged with the hand-held system. One infant was imaged again during follow-up examinations. Robust image processing algorithms were developed to create high-quality images. Images were assessed for usefulness in demonstrating pertinent morphologic features.• RESULTS: The novel SD OCT unit proved effective for data acquisition and comparable with conventional chinrest SD OCT. Rapid data acquisition limited motion artifact within the B-scan, although there was slight motion between B scans. The SD OCT images provided previously unseen details with regard to the morphologic features of retinal lesions in these infant eyes. This information influenced prognosis and management.• CONCLUSIONS: As with adults, the hand-held customized SD OCT proved to be an invaluable tool in the differentiation of disease processes or injury in these eyes under study. SD OCT imaging systems may be considered a useful adjunct to RetCam fundus photography for assessment and clinical management in cases of SBS. (Am J Ophthalmol 2009;147:364 -373.

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Ultrahigh-Resolution Optical Coherence Tomography of Surgically Closed Macular Holes

Abstract: To evaluate retinal anatomy using ultrahighresolution optical coherence tomography (OCT) in eyes after successful surgical repair of full-thickness macular hole.

Cited by 115 publications

References 45 publications

External limiting membrane and visual outcome in macular hole repair: spectral domain OCT analysis

External limiting membrane and visual outcome in macular hole repair: spectral domain OCT analysis

Characterization of Inner Retinal Spots With Inverted Reflectivity on En Face Optical Coherence Tomography in Diabetic Retinopathy

Imaging the Infant Retina with a Hand-held Spectral-Domain Optical Coherence Tomography Device

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