Ultrahigh resolution Fourier domain optical coherence tomography

Leitgeb, Rainer A.; Drexler, Wolfgang; Unterhuber, Angelika; Hermann, B.; Bajraszewski, Tomasz; Le, Thanh Dat; Stingl, A.; Fercher, Adolf Friedrich

doi:10.1364/opex.12.002156

Cited by 350 publications

(185 citation statements)

References 4 publications

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“…Broad-bandwidth superluminescent diode light sources, similar to the one used in this study, recently have been shown to enable UHR OCT image resolution performance approaching that of femtosecond lasers. [27][28][29][30][31][32][33][34][35][36][37][38] Our research prototype high-speed UHR OCT system has been described in detail in previous publications. [29][30][31][32][33] This system can acquire up to 25 000 axial scans per second, corresponding to ~49 images (512 axial scans per image) per second.…”

Section: Methodsmentioning

confidence: 99%

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

et al. 2006

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Objective-To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies. Design-Retrospective cross-sectional study.Participants-Five hundred eighty-eight eyes of 327 patients with various macular pathologies.Methods-High-speed ultrahigh-resolution OCT images were obtained in 588 eyes of 327 patients with selected macular diseases. Ultrahigh-resolution OCT using Fourier/spectral domain detection achieves ~3-μm axial image resolutions, acquisition speeds of ~25 000 axial scans per second, and >3 times finer resolution and >50 times higher speed than standard OCT. Three scan protocols were investigated. The first acquires a small number of high-definition images through the fovea. The second acquires a raster series of high-transverse pixel density images. The third acquires 3-dimensional OCT data using a dense raster pattern. Three-dimensional OCT can generate OCT fundus images that enable precise registration of OCT images with the fundus. Using the OCT fundus images, OCT results were correlated with standard ophthalmoscopic examination techniques. Main Outcome Measures-High-definition macular pathologies.Results-Macular holes, age-related macular degeneration, epiretinal membranes, diabetic retinopathy, retinal dystrophies, central serous chorioretinopathy, and other pathologies were imaged and correlated with ophthalmic examination, standard OCT, fundus photography, and fluorescein angiography, where applicable. High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT. The speed preserves retinal topography, thus enabling the visualization of subtle changes associated with disease. High-definition high-transverse pixel density Conclusions-High-definition 3-dimensional imaging using high-speed ultrahigh-resolution OCT improves image quality, retinal coverage, and registration. This new technology has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.Optical coherence tomography (OCT) is a medical imaging technology that can perform highresolution cross-sectional imaging of tissue morphology in situ and in real time. Optical coherence tomography imaging is analogous to ultrasound, except that it uses light rather than sound and measures the echo time delay and magnitude of reflected or backscattered light using low-coherence interferometry. Cross-sectional images are generated by directing an optical beam onto tissue and scanning it in the transverse direction, thus yielding a data set that can be displayed as false-color or grayscale images. Despite the successful clinical application of OCT technology, there are several limitations. Without using techniques such as eye tracking, the total permissible image acquisition time is limited by subject eye motion, which can cause imag...

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Section: Methodsmentioning

confidence: 99%

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

et al. 2006

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“…Depuis son invention au début des années 1990, l'OCT a connu de nombreux développements. Dans l'OCT spectrale (ou OCT de Fourier), le balayage de la différence de marche est remplacé par une mesure en parallèle du spectre du signal interférométrique, ce qui conduit à une réduction spectaculaire du temps d'acquisition [4][5][6]. L'OCT en lumière polarisée, capable de révéler les propriétés optiques de biréfringence, apporte des informations supplémentaires sur la structure et la composition des tissus [7][8][9].…”

Section: L'oct Plein Champunclassified

L’OCT plein champ

Dubois

Boccara

2006

Med Sci (Paris)

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“…Although a number of broadband light sources have been developed to improve axial resolution in time domain and SD-OCT [21][22][23][24], only a few broadband high-speed wavelength-swept light sources have been reported [25][26][27][28]. Semiconductor gain media can be easily incorporated into compact laser cavity designs and have been developed for many different spectral bands.…”

Section: Introductionmentioning

confidence: 99%

Extended bandwidth wavelength swept laser source for high resolution optical frequency domain imaging

et al. 2017

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Improving the axial resolution by providing wider bandwidth wavelength swept lasers remains an important issue for optical frequency domain imaging (OFDI). Here, we demonstrate a wide tuning range, all-fiber wavelength swept laser at a center wavelength of 1250 nm by combining two ring cavities that share a single Fabry-Perot tunable filter. The two cavities contain semiconductor optical amplifiers with central wavelengths of 1190 nm and 1292 nm, respectively. To avoid disturbing interference effects in the overlapping spectral region, we modulated the amplifiers in order to obtain consecutive wavelength sweeps in the two spectral regions. The two sweeps were fused together in post-processing to achieve a total scanning range of 223 nm, corresponding to 3.3 µm axial resolution in air. We confirm improved image quality and reduced speckle size in tomograms of swine esophagus ex vivo, and human skin and nailbed in vivo.

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Ultrahigh resolution Fourier domain optical coherence tomography

Cited by 350 publications

References 4 publications

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

L’OCT plein champ

Extended bandwidth wavelength swept laser source for high resolution optical frequency domain imaging

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