“…Another specific buffer effect involving Tris, Bis-Tris propane (BTP), TES, HEPES, and cacodylate was observed in DNA digestion kinetics by EcoRV endonuclease [46]. Recently, changing from Tris to CAPS (3-(cyclohexylamino)propane-1-sulfonic acid) buffers, a better sedimentation of DNA was obtained [35]. Buffer choice needs also to be considered in nucleotide formulation stability [17].…”