Ultraflexible organic amplifier with biocompatible gel electrodes

Sekitani, Tsuyoshi; Yokota, Tomoyuki; Kuribara, Kazunori; Kaltenbrunner, Martin; Fukushima, Takanori; Inoue, Yusuke; Sekino, Masaki; Igarashi, Takashi; Abe, Yusuke; Oda, Hiroshi

doi:10.1038/ncomms11425

Cited by 197 publications

(201 citation statements)

References 33 publications

(43 reference statements)

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“…The electrodes were aligned to edges of the microchambers manually to keep their distance almost the same around the microchamber for uniform electrical stimulation of individual spheroids. Hybrids of hydrogel and organic electrodes are useful for biocompatible electronic systems and many types have been reported, however, the composite of PVA hydrogel and PEDOT‐coated CF (CF‐PEDOT) electrodes is reported for the first time as far as we know. The cover made of PVA hydrogel was tightly sealed to the body with pins.…”

Section: Resultsmentioning

confidence: 99%

Hydrogel Microchambers Integrated with Organic Electrodes for Efficient Electrical Stimulation of Human iPSC‐Derived Cardiomyocytes

Yoshida

Sumomozawa

Nagamine

et al. 2019

Macromolecular Bioscience

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A hydrogel‐based microchamber with organic electrodes for efficient electrical stimulations of human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) is described. The microchamber is made from molecularly permeable, optically transparent, and electrically conductive polyvinyl alcohol (PVA) hydrogel and highly capacitive carbon electrode modified with poly(3,4‐ethylenedioxythiophene) (PEDOT). Spheroids of hiPSC‐CMs are cultured in microchambers, and electrically stimulated by the electrode for maturation. The large interfacial capacitance of the electrodes enables several days of electrical stimulation without generation of cytotoxic bubbles even when the electrodes are placed near the spheroids. The spheroids can be cultivated in the closed microchambers because of the permeated nutrients through the hydrogel, thus the spheroids are stably addressable and the culture medium around the sealed microchambers can be simply exchanged. Synchronized beating of the spheroids can be optically analyzed in situ, which makes it possible to selectively collect electrically responsive cells for further use. As the hydrogel is electrically conductive, the amount of electrical charge needed for maturing the spheroids can be reduced by configuring electrodes on the top and the bottom of the microchamber. The bioreactor will be useful for efficient production of matured hiPSC‐CMs for regenerative medicine and drug screening.

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Section: Resultsmentioning

confidence: 99%

Hydrogel Microchambers Integrated with Organic Electrodes for Efficient Electrical Stimulation of Human iPSC‐Derived Cardiomyocytes

Yoshida

Sumomozawa

Nagamine

et al. 2019

Macromolecular Bioscience

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“…e) Typical current–voltage curves of flexible organic transistors. Reproduced under the terms of the CC‐BY Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/) . Copyright 2016, Springer Nature.…”

Section: System Integrationmentioning

confidence: 99%

Cyber–Physiochemical Interfaces

et al. 2020

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Living things rely on various physical, chemical, and biological interfaces, e.g., somatosensation, olfactory/gustatory perception, and nervous system response. They help organisms to perceive the world, adapt to their surroundings, and maintain internal and external balance. Interfacial information exchanges are complicated but efficient, delicate but precise, and multimodal but unisonous, which has driven researchers to study the science of such interfaces and develop techniques with potential applications in health monitoring, smart robotics, future wearable devices, and cyber physical/human systems. To understand better the issues in these interfaces, a cyber–physiochemical interface (CPI) that is capable of extracting biophysical and biochemical signals, and closely relating them to electronic, communication, and computing technology, to provide the core for aforementioned applications, is proposed. The scientific and technical progress in CPI is summarized, and the challenges to and strategies for building stable interfaces, including materials, sensor development, system integration, and data processing techniques are discussed. It is hoped that this will result in an unprecedented multi‐disciplinary network of scientific collaboration in CPI to explore much uncharted territory for progress, providing technical inspiration—to the development of the next‐generation personal healthcare technology, smart sports‐technology, adaptive prosthetics and augmentation of human capability, etc.

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“…As the core of neurophysiologic monitoring, realizing high‐quality signal collection is an important topic in the research of neural electrode arrays. Related researches have indicated that stretchable/flexible neural electrode arrays, with their excellent mechanical and electrical performance, are superior candidates for the next generation of implantable devices 3, 4, 5, 6, 7, 8, 9, 10, 11. The successful development of stretchable/flexible neural electrode arrays hinges on good conformal contact between the array and the tissue, which enables excellent mechanical and electrical properties,3 as well as low‐cost, stable, and high‐throughput manufactural techniques.…”

Section: Introductionmentioning

confidence: 99%

Thermal Release Transfer Printing for Stretchable Conformal Bioelectronics

et al. 2017

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Soft neural electrode arrays that are mechanically matched between neural tissues and electrodes offer valuable opportunities for the development of disease diagnose and brain computer interface systems. Here, a thermal release transfer printing method for fabrication of stretchable bioelectronics, such as soft neural electrode arrays, is presented. Due to the large, switchable and irreversible change in adhesion strength of thermal release tape, a low‐cost, easy‐to‐operate, and temperature‐controlled transfer printing process can be achieved. The mechanism of this method is analyzed by experiments and fracture‐mechanics models. Using the thermal release transfer printing method, a stretchable neural electrode array is fabricated by a sacrificial‐layer‐free process. The ability of the as‐fabricated electrode array to conform different curvilinear surfaces is confirmed by experimental and theoretical studies. High‐quality electrocorticography signals of anesthetized rat are collected with the as‐fabricated electrode array, which proves good conformal interface between the electrodes and dura mater. The application of the as‐fabricated electrode array on detecting the steady‐state visual evoked potentials research is also demonstrated by in vivo experiments and the results are compared with those detected by stainless‐steel screw electrodes.

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Ultraflexible organic amplifier with biocompatible gel electrodes

Cited by 197 publications

References 33 publications

Hydrogel Microchambers Integrated with Organic Electrodes for Efficient Electrical Stimulation of Human iPSC‐Derived Cardiomyocytes

Hydrogel Microchambers Integrated with Organic Electrodes for Efficient Electrical Stimulation of Human iPSC‐Derived Cardiomyocytes

Cyber–Physiochemical Interfaces

Thermal Release Transfer Printing for Stretchable Conformal Bioelectronics

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