Ultrafine medicated fibers electrospun from W/O emulsions

Xu, Xiuling; Yang, L.; Xu, Xiaoyi; Wang, Xin; Chen, Xuesi; Liang, Qizhi; Zeng, Jing; Jing, Xiabin

doi:10.1016/j.jconrel.2005.07.021

Cited by 315 publications

(180 citation statements)

References 18 publications

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“…Emulsion electrospinning is a novel process which prepares core-sheath fibers through stabile polymer emulsion. Xu et al have successfully encapsulated poly(ethylene oxide) (PEO) and doxorubicin hydrochloride in the shell material of poly(ethylene glycol)-poly(L-lactic acid) (PELA) [52,53]. Yang et al aimed at assessing the potential use of emulsion electrospinning to prepare core-shell structured ultrafine fibers as carriers for therapeutic proteins.…”

Section: Electrospun Fibers With Core-shell Structurementioning

confidence: 99%

Electrospun nanofibrous materials for tissue engineering and drug delivery

Cui

Zhou

Chang

2010

Science and Technology of Advanced Materials

430

200

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The electrospinning technique, which was invented about 100 years ago, has attracted more attention in recent years due to its possible biomedical applications. Electrospun fibers with high surface area to volume ratio and structures mimicking extracellular matrix (ECM) have shown great potential in tissue engineering and drug delivery. In order to develop electrospun fibers for these applications, different biocompatible materials have been used to fabricate fibers with different structures and morphologies, such as single fibers with different composition and structures (blending and core-shell composite fibers) and fiber assemblies (fiber bundles, membranes and scaffolds). This review summarizes the electrospinning techniques which control the composition and structures of the nanofibrous materials. It also outlines possible applications of these fibrous materials in skin, blood vessels, nervous system and bone tissue engineering, as well as in drug delivery.

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Section: Electrospun Fibers With Core-shell Structurementioning

confidence: 99%

Electrospun nanofibrous materials for tissue engineering and drug delivery

Cui

Zhou

Chang

2010

Science and Technology of Advanced Materials

430

200

View full text Add to dashboard Cite

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“…[29] Xu et al showed that a water-soluble anticancer agent, doxorubicin hydrochloride, was totally encapsulated within the electrospun poly (ethylene glycol)-poly (l-lactic acid) (PEG-PLLA) fibers when its content in the fibers was 5 wt %. [37] Other advantages of drug-loaded nanofibers, such as small diameter of the nanofibers, can provide short diffusion passage length. Also, high surface area facilitates mass transfer and effective drug release.…”

Section: Novel Strategies Provided By Electrospinning For New Ddsmentioning

confidence: 99%

Electrospun nanofiber-based drug delivery systems

Yu¹,

Zhu²,

White³

et al. 2009

Health

149

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Electrospinning is a very simple and versatile process by which polymer nanofibers with diameters ranging from a few nanometers to several micrometers can be produced using an electrostatically driven jet of polymer solution or polymer melt. Significant progress has been made in this process throughout the past few years and electrospinning has advanced its applications in many fields, including pharmaceutics. Electrospun nanofibers show great promise for developing many types of novel drug delivery systems (DDS) due to their special characteristics and the simple but useful and effective top-down fabricating process. The current state of electrospun nanofiber-based DDS is focused on drug-loaded nanofiber preparation from pharmaceutical and biodegradable polymers and different types of DDS. However, there are more opportunities to be exploited from the electrospinning process and the corresponding drug-loaded nanofibers for drug delivery. Additionally, some other related challenges and the possible resolutions are outlined in this review.

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“…[13][14][15][16][17][18][19][20][21] The very fine diameter and high porous structure of nanofiber mats help drug particles diffuse out of the matrix more efficiently. 14,15 The most popular, preferred, and inexpensive technique for fabricating polymeric nanofibers is electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Jannesari¹,

Varshosaz²,

Morshed³

et al. 2011

IJN

128

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The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol) (PVA), poly(vinyl acetate) (PVAc), and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl), were successfully prepared by an electrospinning technique for the first time. The morphology and average diameter of the electrospun nanofibers were investigated by scanning electron microscopy. X-ray diffraction studies indicated an amorphous distribution of the drug inside the nanofiber blend. Introducing the drug into polymeric solutions significantly decreased solution viscosities as well as nanofiber diameter. In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release. Blending PVA and PVAc exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications. Also, the thickness of the blend nanofiber mats strongly influenced the initial release and rate of drug release.

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Ultrafine medicated fibers electrospun from W/O emulsions

Cited by 315 publications

References 18 publications

Electrospun nanofibrous materials for tissue engineering and drug delivery

Electrospun nanofibrous materials for tissue engineering and drug delivery

Electrospun nanofiber-based drug delivery systems

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

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