Ultrafine carbamazepine nanoparticles with enhanced water solubility and rate of dissolution

Abstract

Solubility of carbamazepine (CBZ) nanoparticles and CBZ–PVP nanoparticles was 11.9 and 21.5 times higher than the raw–CBZ.

Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs

“…It was observed that smaller particles were formed with solvent to antisolvent ratio of 1:250, at 70 °C [53]. This is because acetone having a boiling point of 56 °C evaporates at this temperature and evaporation assisted solvent-antisolvent interaction leads to smaller particle size, irrespective of the solute being precipitated [36,53]. Similarly, the effect of ratio of solvent to antisolvent on particle size also may not change for the same pair of solvent and antisolvent.…”

“…EASAI method is an effective method for the preparation of both bare drug nanoparticles as well as polymer stabilized nanoparticles with average particle size well below 100 nm. In the EASAI method, the rate of precipitation is enhanced by using conditions favouring evaporation of the solvent [36].…”

Preparation and characterization of polyvinyl alcohol stabilized griseofulvin nanoparticles

“…The GF-PVA nanoparticles were prepared using the EASAI method [13,15,16,24]. The detailed experimental procedure is described elsewhere [15,16].…”

“…[20,22] GF is a highly hydrophobic drug having low solubility and hence, low bioavailability and it exhibits incomplete absorption through the gastrointestinal tract [23]. We have recently shown that solubility of drugs such as CBZ and GF can be enhanced manifold by nanoformulating it with polymeric stabilizers [15,16].…”

“…The same method can be used to produce polymer stabilized drug nanoparticles when the polymer is present in the antisolvent. Here, we report the preparation of GF-PVA nanoparticles with particles size below 30 nm and spherical morphology using EASAI method [15,16].…”