Ultrafiltration With the MacNeill-Collins Blood Dialyzer

Isolated Ultrafiltration: Its Origin and Early Development

“…From the late 1940s to the 1960s, dialyzers that featured plates, tubes, or capillaries, in addition to possessing enclosed dialysate compartments, began to be readily available. Examples of such dialyzers included the Skeggs‐Leonards dialyzer, the MacNeill type dialyzer (e.g., the MacNeill‐Collins dialyzer), and the Kiil dialyzer . Both the Skeggs‐Leonards and the Kiil dialyzers were plate devices while the MacNeill‐type devices possessed parallel straight cellophane tubes .…”

“…Examples of such dialyzers included the Skeggs‐Leonards dialyzer, the MacNeill type dialyzer (e.g., the MacNeill‐Collins dialyzer), and the Kiil dialyzer . Both the Skeggs‐Leonards and the Kiil dialyzers were plate devices while the MacNeill‐type devices possessed parallel straight cellophane tubes . In all these dialyzers, the presence of a rigid, enclosed dialysate compartment allowed the ready generation of a negative hydrostatic pressure in this space by the use of a vacuum‐creating mechanism so that IUF could be easily carried out.…”

“…In 1961, McLean and Clason presented their successful in vitro (on stored human blood) and in vivo (on dogs) results of IUF using MacNeill‐Collins dialyzers .…”