Ultrafiltration

Composition of Peritoneal Dialysis Solutions: Potential Hazards

“…Solutions using amino acids as osmotic agent are also of interest. A 2 % amino acid solution produced similar ultrafiltration to 4.25% glucose solution and was thought to provide an important source of protein [32,33], Glucose in peritoneal dialysis is not a static entity and will undergo spontaneous degradation to various intermediate species including 5-hydroxymethylfurfural (5-HMF), brown discolouration products and formic and laevulinic acids [34], This process is accelerated by heat (as in autoclaving) and by age -fluid over 18 months after manufac ture contains significantly higher levels of glucose degradation products [35]. 5-HMF per se is relatively non-toxic but may com bine with thiol and amino groups yielding substances which may be cytotoxic [36].…”