Ultrafiltration coefficient and glomerular capillary resistance in a model of immune complex glomerulonephritis

Savin, Virginia J.; Lindsley, Herbert B.; Nagle, Raymond B.; Cachia, Richard

doi:10.1038/ki.1982.5

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…A final parameter in the filtration equation is the ultrafiltration coefficient K f , which is the product of the hydraulic conductivity of the capillary (L p ) and the effective surface area for filtration (S f ). 18 The K f of the renal glomeruli is significantly higher than Figure 1 Legend on next page other capillary beds and mesangial cell contraction can result in significant changes in the S f component of K f . All these aforementioned parameters will be influenced by HF (Figure 1) and therefore also by the pharmacological therapies used for the treatment of HF.…”

Section: Glomerular Functionmentioning

confidence: 98%

“…Importantly, the FF determines the amount of sodium and water which will be reabsorbed in the proximal parts of the tubules 16 (a process known as glomerulotubular balance). A final parameter in the filtration equation is the ultrafiltration coefficient K f , which is the product of the hydraulic conductivity of the capillary (L p ) and the effective surface area for filtration (S f ) 18 . The K f of the renal glomeruli is significantly higher than other capillary beds and mesangial cell contraction can result in significant changes in the S f component of K f .…”

Section: Kidney Physiology In Health and Heart Failurementioning

confidence: 99%

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Renal effects of guideline‐directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology

Mullens

Martens

Testani

et al. 2022

European J of Heart Fail

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Novel pharmacologic treatment options reduce mortality and morbidity in a cost-effective manner in patients with heart failure (HF). Undisputedly, the effective implementation of these agents is an essential element of good clinical practice, which is endorsed by the European Society of Cardiology (ESC) guidelines on acute and chronic HF. Yet, physicians struggle to implement these therapies as they have to balance the true and/or perceived risks versus their substantial benefits in clinical practice. Any worsening of biomarkers of renal function is often perceived as being disadvantageous and is in clinical practice one of the most common reasons for ineffective drug implementation. However, even in this context, they clearly reduce mortality and morbidity in HF with reduced ejection fraction (HFrEF) patients, even in patients with poor renal function. Furthermore these agents are also beneficial in HF with mildly reduced ejection fraction (HFmrEF) and sodium-glucose cotransporter 2 (SGLT2) inhibitors more recently demonstrated a beneficial effect in HF with preserved ejection fraction (HFpEF). The emerge of several new classes (angiotensin receptor-neprilysin inhibitor [ARNI], SGLT2 inhibitors, vericiguat, omecamtiv mecarbil) and the recommendation by the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic HF of early initiation

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Section: Glomerular Functionmentioning

confidence: 98%

Section: Kidney Physiology In Health and Heart Failurementioning

confidence: 99%

Renal effects of guideline‐directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology

Mullens

Martens

Testani

et al. 2022

European J of Heart Fail

View full text Add to dashboard Cite

show abstract

“…Relative capillary volume increment was calculated for each glomerulus as a qualitative measure of the net effects of the elastic and compliance properties of the capillary. The erythrocyte ejection is a function of the patency of the glomerular capillaries and is diminished in inflammatory states (11). It was assessed using a semiquantitative scale with a range of 0 to 4+.…”

Section: Methodsmentioning

confidence: 99%

Diminished Glomerular Capillary Hydraulic Conductivity Precedes Morphologic Changes in Experimental Diabetes Mellitus in the Rat

Ellis

Wiegmann²,

Savin³

1992

Diabetes

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Glomerular ultrafiltration coefficient, Kf, is diminished in established diabetic nephropathy. To determine whether Kf is decreased because of a decrease in capillary area, A, and or in hydraulic conductivity, Lp, glomerular Kf and morphometric parameters were measured, and Lp was calculated in glomeruli of young rats with STZ-induced DM and in control rats. STZ was administered to Fischer 344 rats that weighted 50-75 g; glomeruli were examined after 3 or 5 mo of DM, and their structure and function was compared with that of control rats. The effects of insulin or of an ACEI, enalapril, also were assessed after 3 or 5 mo. Growth of DM rats was markedly impaired, and their ratio of kidney weight to body weight was increased. Ccr was proportional to rat weight, and the ratio of Ccr to body weight was not different in DM and control rats. At 3 mo, average volume of glomeruli isolated from DM rats was less than that of glomeruli from control rats. In contrast, glomerular volume after 5 mo was equal in DM and control rats. No increase in GBM thickness or mesangial volume was observed, nor was any decrease seen in GBM area in DM rats at 5 mo. Kf was lower in DM rats than controls after 3 mo, but not after 5 mo. The Lp of DM and control glomeruli did not differ at 3 mo, but was lower in DM at 5 mo. Insulin therapy improved somatic growth and increased kidney and glomerular size in DM rats; the kidney weight/body weight ratio remained elevated.(ABSTRACT TRUNCATED AT 250 WORDS)

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Evaluation of Function in Single Segments of Isolated Renal Blood Vessels, Nephrons, and Collecting Ducts

Welling

Edwards

1992

Comprehensive Physiology

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The sections in this article are: Glomerulus and Vessels Mammalian Nonmammalian Proximal Tubule Mammalian Nonmammalian Thin Limbs of Henle's Loop Mammalian Thick Ascending Limbs of Henle's Loop Mammalian Nonmammalian Distal Convoluted and Connecting Segments Mammalian Nonmammalian Collecting Tubules and Ducts Mammalian Nonmammalian

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Ultrafiltration coefficient and glomerular capillary resistance in a model of immune complex glomerulonephritis

Cited by 8 publications

References 15 publications

Renal effects of guideline‐directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology

Renal effects of guideline‐directed medical therapies in heart failure: a consensus document from the Heart Failure Association of the European Society of Cardiology

Diminished Glomerular Capillary Hydraulic Conductivity Precedes Morphologic Changes in Experimental Diabetes Mellitus in the Rat

Evaluation of Function in Single Segments of Isolated Renal Blood Vessels, Nephrons, and Collecting Ducts

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