Ultrafast Multidimensional NMR: Principles and Practice of Single-Scan Methods

Gal, Maayan; Frydman, Lucio

doi:10.1002/9780470034590.emrstm1024

Cited by 15 publications

(12 citation statements)

References 26 publications

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“…This is particularly constraining for ultrafast methods, where the low sensitivity of heteronuclei requires that protons are sampled in the conventional dimension, whereas the long range heteronucleus is detected in the spatially-encoded dimension. Therefore, we evaluated the approach described above in the case of a 1 H-13 C ultrafast heteronuclear correlation [27]. The studied sample is a mixture of three compounds engaged into a chemical equilibrium: methanol, formic acid and the resulting ester, methyl formate.…”

Section: Resultsmentioning

confidence: 99%

A new gradient-controlled method for improving the spectral width of ultrafast 2D NMR experiments

Giraudeau

Akoka

2010

Journal of Magnetic Resonance

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Section: Resultsmentioning

confidence: 99%

A new gradient-controlled method for improving the spectral width of ultrafast 2D NMR experiments

Giraudeau

Akoka

2010

Journal of Magnetic Resonance

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“…The W5 binomial π pulse (Liu et al 1998) was used as a solvent-exclusive π pulse in the WS module, and parameters for crasher gradient pulses in this module were sensitivity G 1 and G 2 , and their duration τ w . The π-chirped pulses were created from Pbox subroutine libraries at a digitization rate of 1.0 μs with an adiabatic coefficient of 4 to fulfill adiabatic passage requirements (Gal and Frydman 2008) and were modulated with a wideband uniform-rate and smooth truncation (WURST) profile. The chirped pulse sweep width and the sweep duration are denoted by τ ad and τ pdur .…”

Section: Methodsmentioning

confidence: 99%

Two-Dimensional J-Resolved NMR Analyses of Fish and Its Products via Spatially Encoded Intermolecular Double-Quantum Coherences

et al. 2015

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Nuclear magnetic resonance (NMR) spectroscopy provides a powerful tool for food analyses due to its highthroughput information related to component analyses and its non-invasive property without altering detected samples. Current liquid NMR approaches, however, are subject to the influence of field inhomogeneity in direct measurements of biological foods, generally resorting to techniques of tissue extractions or magic-angle spin to eliminate the inhomogeneity. Therefore, we propose an NMR approach based on intermolecular double-quantum coherences (iDQCs) and spatial encoding technique to fast recover high-resolution two-dimensional (2D) J-resolved spectra in inhomogeneous fields. Inheriting from the immunity to field inhomogeneity of iDQCs and the enhancement in acquisition efficiency of the spatial encoding technique, the proposed method can resist the field inhomogeneity in biological foods without superfluous pretreatments and time-consuming shimming procedures, and yield satisfactory 2D J-resolved information for analyses within minutes. Fish and its products, which are closely related to human daily life, capture extensive attentions with the rapid development of the aquaculture. At first, experiments on cod liver oils are implemented in a purposely deshimmed magnetic field to demonstrate the feasibility of the proposed approach. Then, caviars and an intact fish are tested to further show the applicability of the proposed approach for direct measurements on intact biological food samples. Herein, the proposed method may constitute an effective technique in analyzing fish and its products.

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“…Although the principles of ultrafast 2D MRS spectroscopy have been described in detail , it is convenient to revisit their use for the specific purpose of this study, addressing joint SPSP selectivity. SPEN departs from traditional schemes in that instead of triggering the chemical shift evolution homogenously, it allows various chemical sites to accrue their spin evolution in a spatially heterogeneous fashion.…”

Section: Theorymentioning

confidence: 99%

“…This process can be exploited to collect arbitrarily high multidimensional images, spectra, or spectroscopic images within a single scan (12). In MRI, SPEN thereby provides an alternative to EPI (13)(14)(15)(16); in 2D MRS (17)(18)(19) it provides a general approach, for which no other "ultrafast" alternatives exist.…”

mentioning

confidence: 99%