Ultrafast laser micromanufacturing of microfluidic devices

Orazi, Leonardo; Siciliani, Vincenzina; Pelaccia, Riccardo; Oubellaouch, Keltoum; Reggiani, Barbara

doi:10.1016/j.procir.2022.06.023

Cited by 12 publications

(6 citation statements)

References 17 publications

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“…Laser subtractive manufacturing has seen widespread adoption in the field of micromanufacturing, particularly in the realm of non-equilibrium thermal ablation [37]. The 'meltfree' processing characteristics of ultrashort pulse laser ablation materials have garnered significant attention in microfabrication fields.…”

Section: Laser Subtractive Manufacturing Theorymentioning

confidence: 99%

Laser-based bionic manufacturing

Li,

Zhang,

Jakobi

et al. 2024

Int. J. Extrem. Manuf.

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Over millions of years of natural evolution, organisms have developed nearly perfect structures and functions. The self-fabrication of organisms serves as a valuable source of inspiration for designing the next-generation of structural materials, and is driving the future paradigm shift of modern materials science and engineering. However, the complex structures and multifunctional integrated optimization of organisms far exceed the capability of artificial design and fabrication technology, and new manufacturing methods are urgently needed to achieve efficient reproduction of biological functions. As one of the most valuable advanced manufacturing technologies of the 21st century, laser processing technology provides an efficient solution to the critical challenges of bionic manufacturing. This review outlines the processing principles, manufacturing strategies, potential applications, challenges, and future development outlook of laser processing in bionic manufacturing domains. Three primary manufacturing strategies for laser-based bionic manufacturing are proposed: subtractive manufacturing, equivalent manufacturing, and additive manufacturing. The progress and trends in bionic subtractive manufacturing applied to micro/nano structural surfaces, bionic equivalent manufacturing for surface strengthening, and bionic additive manufacturing aiming to achieve bionic spatial structures, are reported. Finally, the key problems faced by laser-based bionic manufacturing, its limitations, and the development trends of its existing technologies are discussed.

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Section: Laser Subtractive Manufacturing Theorymentioning

confidence: 99%

Laser-based bionic manufacturing

Li,

Zhang,

Jakobi

et al. 2024

Int. J. Extrem. Manuf.

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“…Silicon is a popular choice due to its chemical compatibility, resistance, and design flexibility ( da Ponte et al, 2021 ). While glass is transparent, biocompatible, and electrically insulating ( Orazi et al, 2022 ; Shubhava et al, 2022 ). However, both materials are expensive to manufacture and require specialized equipment and cleanroom facilities to ensure their purity and reliability ( Elvira et al, 2022 ; Leung et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

Rodríguez

Andrade-Pérez

Vargas

et al. 2023

Front. Bioeng. Biotechnol.

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Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is to provide high precision and accuracy while using minimal reagents and equipment. The benefits of this approach include greater control over experimental conditions, faster analysis, and improved experimental reproducibility. Microfluidic devices, also known as labs-on-a-chip (LOCs), have emerged as potential instruments for optimizing operations and decreasing costs in various of industries, including pharmaceutical, medical, food, and cosmetics. However, the high price of conventional prototypes for LOCs devices, generated in clean room facilities, has increased the demand for inexpensive alternatives. Polymers, paper, and hydrogels are some of the materials that can be utilized to create the inexpensive microfluidic devices covered in this article. In addition, we highlighted different manufacturing techniques, such as soft lithography, laser plotting, and 3D printing, that are suitable for creating LOCs. The selection of materials and fabrication techniques will depend on the specific requirements and applications of each individual LOC. This article aims to provide a comprehensive overview of the numerous alternatives for the development of low-cost LOCs to service industries such as pharmaceuticals, chemicals, food, and biomedicine.

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“…A more consolidated approach is to create the 2.5D structures on the surface of the glass and seal it with a silicon cover, to create a closed channel [8,11]. By allowing the depth and width of each channel to vary, this approach offers a straightforward method to increase the precision of the generated geometries [12]. An aspect to consider is that the microchannel surface roughness can be altered by laser irradiation.…”

Section: Introductionmentioning

confidence: 99%

UV picosecond laser processing for microfluidic applications

Siciliani

2023

Materials Research Proceedings

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Abstract. In recent years, the fields of nanomedicine and nanopharmaceuticals have seen extensive use of microfluidic technologies. A microfluidic system transports fluids through micrometer-sized channels usually generated by replication on silicones. However, using laser technology and glass material together reduces manufacturing time, while maintaining high accuracy, and has the greatest benefit of being flexible. In this frame, the work aims to evaluate the potential of an ultrafast laser source for rapid and precise prototyping of a glass micromixer device. The study involves scanning electron microscopy to analyze the morphology, and confocal microscopy to investigate the topography of the sample. In addition, the study investigates the main process strategy to gain optimization of the processing time. Finally, the functionality of the manufactured devices is assessed, through a mixing test of two fluids with different pH.

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Ultrafast laser micromanufacturing of microfluidic devices

Cited by 12 publications

References 17 publications

Laser-based bionic manufacturing

Laser-based bionic manufacturing

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

UV picosecond laser processing for microfluidic applications

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