Ultrafast imaging in biomedical ultrasound

Tanter, Mickaël; Fink, Mathias

doi:10.1109/tuffc.2014.6689779

Cited by 556 publications

(302 citation statements)

References 118 publications

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“…Flash mode is known to provide relatively poor spatial resolution in the transverse direction [34], [35] that was not critical in this pilot study, but would certainly be unacceptable in a clinical setting. However, since the number of pulses in a Doppler ensemble can be substantially reduced, it is potentially feasible to utilize multiple transmit beams or incident angles within the same imaging time, and enhance image resolution through coherent spatial compounding.…”

Section: Discussionmentioning

confidence: 99%

A new active cavitation mapping technique for pulsed HIFU applications-bubble doppler

Khokhlova

Sapozhnikov

et al. 2014

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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In this work, a new active cavitation mapping technique for pulsed high-intensity focused ultrasound (pHIFU) applications termed bubble Doppler is proposed and its feasibility tested in tissue-mimicking gel phantoms. pHIFU therapy uses short pulses, delivered at low pulse repetition frequency, to cause transient bubble activity that has been shown to enhance drug and gene delivery to tissues. The current gold standard for detecting and monitoring cavitation activity during pHIFU treatments is passive cavitation detection (PCD), which provides minimal information on the spatial distribution of the bubbles. B-mode imaging can detect hyperecho formation, but has very limited sensitivity, especially to small, transient microbubbles. The bubble Doppler method proposed here is based on a fusion of the adaptations of three Doppler techniques that had been previously developed for imaging of ultrasound contrast agents – color Doppler, pulse inversion Doppler, and decorrelation Doppler. Doppler ensemble pulses were interleaved with therapeutic pHIFU pulses using three different pulse sequences and standard Doppler processing was applied to the received echoes. The information yielded by each of the techniques on the distribution and characteristics of pHIFU-induced cavitation bubbles was evaluated separately, and found to be complementary. The unified approach - bubble Doppler – was then proposed to both spatially map the presence of transient bubbles and to estimate their sizes and the degree of nonlinearity.

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Section: Discussionmentioning

confidence: 99%

A new active cavitation mapping technique for pulsed HIFU applications-bubble doppler

Khokhlova

Sapozhnikov

et al. 2014

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…The field of view was 38.4 mm (lateral) by 40 mm (in depth). This technique is commonly used for shear wave Elastography, ultrafast contrast imaging, and functional ultrasound imaging of brain activity 31–33 . Both the linear array transducer (used for plane wave imaging) and the single element transducer (used for stimulation) were synchronously triggered using LabVIEW NI-DAQmx (National Instruments, Austin, TX, USA) with a precision of 50 ns ± 5 ns.…”

Section: Methodsmentioning

confidence: 99%

Study of Poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAM) Microgel Particle Induced Deformations of Tissue-Mimicking Phantom by Ultrasound Stimulation

Joshi¹,

Nandi

Chester

et al. 2018

Langmuir

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Poly (N-isopropylacrilamide) (pNIPAm) microgels (microgels) are colloidal particles that have been used extensively for biomedical applications. Typically, these particles are synthesized in the presence of an exogenous cross-linker, such as N, N′-Methylenebis (acrylamide) (BIS); however, recent studies have demonstrated that pNIPAm microgels can be synthesized in the absence of an exogenous crosslinker, resulting in the formation of ultra-low crosslinked (ULC) particles, which are highly deformable. Microgel deformability has been linked in certain cases to enhanced bioactivity when ULC microgels are used for the creation of biomimetic particles. We hypothesized that ultrasound stimulation of microgels would enhance particle deformation and that the degree of enhancement would negatively correlate with the degree of particle crosslinking. Here, we demonstrate in tissue-mimicking phantoms that using ultrasound insonification causes deformations of ULC microgel particles. Furthermore, the amount of deformation depends on the ultrasound excitation frequency and amplitude, and on the concentration of ULC microgel particles. We observed that the amplitude of deformation increases with increasing ULC microgel particle concentration up to 2.5 mg / 100 ml, but concentrations higher than 2.5 mg / 100 ml result in reduced amount of deformation. In addition, we observed that the amplitude of deformation was significantly higher at 1 MHz insonification frequency. We also report that increasing the degree of microgel crosslinking reduces the magnitude of the deformation and increases the optimal concentration required to achieve the largest amount of deformation. Stimulated ULC microgel particle deformation has numerous potential biomedical applications, including enhancement of localized drug delivery and biomimetic activity. These results demonstrate the potential of ultrasound stimulation for such applications.

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“…Nonetheless, because current H-scan techniques use focused ultrasound data acquisitions, spatial resolution degrades away from the focal region and inherently affects relative scatterer size estimation compared with plane wave imaging, which instantaneously exposes the entire image field with nearly uniform acoustic intensity, with the exception of depth-dependent attenuation that can be corrected for, in part, by using time-gain compensation. The resolution of ultrasound plane wave imaging can be inferior to that of traditional focused ultrasound approaches; the former exhibits homogeneous spatial resolution throughout the image plane that can be improved through spatial angular compounding (Couture et al 2012; Tanter and Fink 2014). …”

Section: Introductionmentioning

confidence: 99%

Spatial Angular Compounding Technique for H-Scan Ultrasound Imaging

Khairalseed

Xiong

Kim

et al. 2018

Ultrasound in Medicine & Biology

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H-Scan is a new ultrasound imaging technique that relies on matching a model of pulse-echo formation to the mathematics of a class of Gaussian-weighted Hermite polynomials. This technique may be beneficial in the measurement of relative scatterer sizes and in cancer therapy, particularly for early response to drug treatment. Because current H-scan techniques use focused ultrasound data acquisitions, spatial resolution degrades away from the focal region and inherently affects relative scatterer size estimation. Although the resolution of ultrasound plane wave imaging can be inferior to that of traditional focused ultrasound approaches, the former exhibits a homogeneous spatial resolution throughout the image plane. The purpose of this study was to implement H-scan using plane wave imaging and investigate the impact of spatial angular compounding on H-scan image quality. Parallel convolution filters using two different Gaussian-weighted Hermite polynomials that describe ultrasound scattering events are applied to the radiofrequency data. The H-scan processing is done on each radiofrequency image plane before averaging to get the angular compounded image. The relative strength from each convolution is color-coded to represent relative scatterer size. Given results from a series of phantom materials, H-scan imaging with spatial angular compounding more accurately reflects the true scatterer size caused by reductions in the system point spread function and improved signal-to-noise ratio. Preliminary in vivo H-scan imaging of tumor-bearing animals suggests this modality may be useful for monitoring early response to chemo-therapeutic treatment. Overall, H-scan imaging using ultrasound plane waves and spatial angular compounding is a promising approach for visualizing the relative size and distribution of acoustic scattering sources.

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Ultrafast imaging in biomedical ultrasound

Cited by 556 publications

References 118 publications

A new active cavitation mapping technique for pulsed HIFU applications-bubble doppler

A new active cavitation mapping technique for pulsed HIFU applications-bubble doppler

Study of Poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAM) Microgel Particle Induced Deformations of Tissue-Mimicking Phantom by Ultrasound Stimulation

Spatial Angular Compounding Technique for H-Scan Ultrasound Imaging

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