Ultrafast Doppler Reveals the Mapping of Cerebral Vascular Resistivity in Neonates

Demené, Charlie; Pernot, Mathieu; Biran, Valérie; Alison, Marianne; Fink, Mathias; Baud, Olivier; Tanter, Mickaël

doi:10.1038/jcbfm.2014.49

Cited by 75 publications

(69 citation statements)

References 29 publications

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“…It is demonstrated that CFPD can be utilized in conjunction with the plane-wave transmit coherent angular compounding technique. Plane-wave transmit coherent angular compounding has previously been demonstrated with ultrasfast Doppler imaging [14], [37]. The combination of this synthetic transmit aperture technique and Doppler imaging suffers from poor SNR because of the low number of transmits contributing to the synthetic transmit.…”

Section: Discussionmentioning

confidence: 99%

Coherent flow power doppler (CFPD): flow detection using spatial coherence beamforming

Dahl

2015

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Power Doppler imaging is a widely used method of flow detection for tissue perfusion monitoring, inflammatory hyperemia detection, deep vein thrombosis diagnosis, and other clinical applications. However, thermal noise and clutter limit its sensitivity and ability to detect slow flow. In addition, large ensembles are required to obtain sufficient sensitivity, which limits frame rate and yields flash artifacts during moderate tissue motion. We propose an alternative method of flow detection using the spatial coherence of backscattered ultrasound echoes. The method enhances slow flow detection and frame rate, while maintaining or improving the signal quality of conventional power Doppler techniques. The feasibility of this method is demonstrated with simulations, flow-phantom experiments, and an in-vivo human thyroid study. In comparison to conventional power Doppler imaging, the proposed method can produce Doppler images with 15-30 dB SNR improvement. Therefore, it is able to detect flow with velocities approximately 50% lower than conventional power Doppler, or improve the frame rate by a factor of 3 with comparable image quality. The results show promise for clinical applications of the method.

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Section: Discussionmentioning

confidence: 99%

Coherent flow power doppler (CFPD): flow detection using spatial coherence beamforming

Dahl

2015

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…Other perfusion quantification Doppler techniques include ultrafast Doppler, which has the benefit of quickly mapping the vascular dynamics of a large region of interest rapidly [89]. This may aid in identifying the full extent of injury in HII, but additional studies are needed to delineate the utility of this technique in practice.…”

Section: Advances In Ultrasonography Techniquesmentioning

confidence: 99%

Head Ultrasound in Neonatal Hypoxic-Ischemic Injury and Its Mimickers for Clinicians: A Review of the Patterns of Injury and the Evolution of Findings Over Time

et al. 2018

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Hypoxic-ischemic injury (HII) of the neonatal brain and resulting clinical hypoxic-ischemic encephalopathy remains a significant cause of morbidity and mortality in the neonatal population. Ultrasound (US) has emerged as a powerful screening tool for evaluation of a neonate with suspected HII. The pattern of injury on brain imaging has crucial implications in therapies and predicted neurodevelopmental outcomes. US has become increasingly effective at determining the pattern, timing, and extent of injury in HII as well as differentiating these findings from a host of diagnoses that can result in a similarly appearing clinical picture. Repeated US studies over a patient’s course can define the evolution of findings from the acute through chronic phase in addition to identifying any complications of therapy. US also has the added benefits of easy portability, no need for patient sedation, and a relatively low cost when compared to other imaging modalities like magnetic resonance imaging (MRI). It is crucial that clinicians understand the full capabilities of advanced US in identifying an underlying diagnosis, directing appropriate therapy, monitoring disease progress, and finally in predicting outcomes, thus improving the care of neonates with encephalopathy. The following article demonstrates the breadth of uses for US in the full-term neonate with encephalopathy, its limitations, the patterns of injury seen, and their evolution over time. We will also briefly review several clinical mimickers of HII for comparison.

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“…The large ensemble length also enables the use of a spatiotemporal filter [7], which is effective at suppressing tissue motion signals. The technique has been applied to rat brain imaging at a frame rate of 1.42 Hz [8], as well as neonatal brain imaging [9]. However, ultrafast Doppler imaging is still limited at large imaging depths, where focusing quality and image SNR must be traded off to maintain frame rate or ensemble length.…”

Section: Introductionmentioning

confidence: 99%

Visualization of Small-Diameter Vessels by Reduction of Incoherent Reverberation With Coherent Flow Power Doppler

Hyun

Abou‐Elkacem

et al. 2016

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Power Doppler (PD) imaging is a widely used technique for flow detection. Despite the wide use of Doppler ultrasound, limitations exist in the ability of Doppler ultrasound to assess slow flow in small-diameter vasculature, such as the maternal spiral arteries and fetal villous arteries of the placenta and focal liver lesions. The sensitivity of PD in small vessel detection is limited by the low signal produced by slow flow and the noise associated with small vessels. The noise sources include electronic noise, stationary or slowly moving tissue clutter, reverberation clutter, and off-axis scattering from tissue, among others. In order to provide more sensitive detection of slow flow in small diameter vessels, a coherent flow imaging technique, termed coherent flow power Doppler (CFPD), is characterized and evaluated with simulation, flow-phantom experiment studies, and an in vivo animal small vessel detection study. CFPD imaging was introduced as a technique to detect slow blood flow. It has been demonstrated to detect slow flow below the detection threshold of conventional power Doppler (PD) imaging using identical pulse sequences and filter parameters. In this study, we compare CFPD to PD in the detection of blood flow in small-diameter vessels. The results from the study suggest that CFPD is able to provide 7.5–12.5 dB increase in the signal-to-noise ratio (SNR) over power Doppler images for the same physiological conditions, and is less susceptible to reverberation clutter and thermal noise. Due to the increase in SNR, CFPD is able to detect small vessels in high channel noise cases, for which PD was unable to generate enough contrast to observe the vessel.

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Ultrafast Doppler Reveals the Mapping of Cerebral Vascular Resistivity in Neonates

Cited by 75 publications

References 29 publications

Coherent flow power doppler (CFPD): flow detection using spatial coherence beamforming

Coherent flow power doppler (CFPD): flow detection using spatial coherence beamforming

Head Ultrasound in Neonatal Hypoxic-Ischemic Injury and Its Mimickers for Clinicians: A Review of the Patterns of Injury and the Evolution of Findings Over Time

Visualization of Small-Diameter Vessels by Reduction of Incoherent Reverberation With Coherent Flow Power Doppler

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