Ultrafast acousto-optic imaging with ultrasonic plane waves

Laudereau, Jean-Baptiste; Grabar, A. A.; Tanter, Mickaël; Gennisson, Jean‐Luc; Ramaz, François

doi:10.1364/oe.24.003774

Cited by 15 publications

(17 citation statements)

References 24 publications

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“…This is because the dimension of the AOTM with L ultrasound foci would result in a matrix with L × M × N SLM elements. The size of the matrix, and the acquisition time, may be lowered by replacing the focused ultrasound beams with ultrasonic plane waves, or other parallelized measurements, which can be digitally coherently combined to synthetize various ultrasonic foci in 3D 59,60 . The AOTM could also be extended to non-monochromatic optical illumination, providing spectral, and temporal information on the medium’s response, This could be realized by using ultrashort optical pulses 16 , or spectrally tunable sources 61 , but would results in even higher dimensionality of the AOTM.…”

Section: Discussionmentioning

confidence: 99%

Controlling light in complex media beyond the acoustic diffraction-limit using the acousto-optic transmission matrix

et al. 2019

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Studying the internal structure of complex samples with light is an important task but a difficult challenge due to light scattering. While the complex optical distortions induced by scattering can be effectively undone if the medium’s scattering-matrix is known, this matrix generally cannot be retrieved without the presence of an invasive detector or guide-star at the target points of interest. To overcome this limitation, the current state-of-the-art approaches utilize focused ultrasound for generating acousto-optic guide-stars, in a variety of different techniques. Here, we introduce the acousto-optic transmission matrix (AOTM), which is an ultrasonically-encoded, spatially-resolved, optical scattering-matrix. The AOTM provides both a generalized framework to describe any acousto-optic based technique, and a tool for light control and focusing beyond the acoustic diffraction-limit inside complex samples. We experimentally demonstrate complex light control using the AOTM singular vectors, and utilize the AOTM framework to analyze the resolution limitation of acousto-optic guided focusing approaches.

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Section: Discussionmentioning

confidence: 99%

Controlling light in complex media beyond the acoustic diffraction-limit using the acousto-optic transmission matrix

et al. 2019

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“…By using a random model for the movement of the blood cells, we have shown that an SVD approach can separate the blood signal from the clutter signal. Our model and results open a door for a mathematical and numerical framework for realizing super-resolution in dynamic optical coherence tomography [12], in ultrafast ultrasound imaging by tracking microbubbles [9], as well as in acousto-optic imaging based on the use of ultrasound plane waves instead of focused ones, which allows to increase the imaging rate drastically [13]. These three modalities are under investigation and their mathematical and numerical modeling will be the subject of forthcoming papers.…”

Section: Discussionmentioning

confidence: 93%

Mathematical Analysis of Ultrafast Ultrasound Imaging

Alberti¹,

Ammari²,

Romero³

et al. 2017

SIAM J. Appl. Math.

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This paper provides a mathematical analysis of ultrafast ultrasound imaging. This\ud newly emerging modality for biomedical imaging uses plane waves instead of focused waves in order\ud to achieve very high frame rates. We derive the point spread function of the system in the Born\ud approximation for wave propagation and study its properties. We consider dynamic data for blood\ud flow imaging, and introduce a suitable random model for blood cells. We show that a singular\ud value decomposition method can successfully remove the clutter signal by using the different spatial\ud coherences of tissue and blood signals, thereby providing high-resolution images of blood vessels,\ud even in cases when the clutter and blood speeds are comparable in magnitude. Several numerical\ud simulations are presented to illustrate and validate the approach

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“…The acquisition time can be shortened by orders of magnitude using faster detection approaches, such as lock-in camera detection [27], and fast cameras [28]. Another approach for improved acquisition time is using an ultra-fast plane-wave AOT approach [25], based on nonlinear crystals.…”

Section: Discussionmentioning

confidence: 99%

Acousto optic imaging beyond the acoustic diffraction limit using speckle decorrelation

2020

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Acousto-optic tomography (AOT) enables optical-contrast imaging deep inside scattering samples via localized ultrasound modulation of scattered light. However, the resolution of AOT is inherently limited by the ultrasound focus size, prohibiting microscopic investigations. In the last few years, advances in the field of digital wavefront-shaping have allowed the development of novel approaches for overcoming the acoustic resolution limit of AOT. However, these novel approaches require the execution of thousands of wavefront measurements within the sample speckle decorrelation time, limiting their application to static samples. Here, we show that it is possible to surpass the acoustic resolution limit with a conventional AOT system by exploiting the natural dynamics of speckle decorrelations rather than trying to overcome them. We achieve this by adapting the principles of super-resolution optical fluctuations imaging (SOFI), originally developed for imaging blinking fluorophores, to AOT. We show that naturally fluctuating optical speckle grains can serve as the analogues of blinking fluorophores, enabling super-resolution by statistical analysis of fluctuating acousto-optic signals.

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Ultrafast acousto-optic imaging with ultrasonic plane waves

Cited by 15 publications

References 24 publications

Controlling light in complex media beyond the acoustic diffraction-limit using the acousto-optic transmission matrix

Controlling light in complex media beyond the acoustic diffraction-limit using the acousto-optic transmission matrix

Mathematical Analysis of Ultrafast Ultrasound Imaging

Acousto optic imaging beyond the acoustic diffraction limit using speckle decorrelation

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